Eyedew

Eyedew Uses, Dosage, Side Effects, Food Interaction and all others data.

The combination of Carboxymethylcellulose Sodium and Glycerin relieves the symptoms of dry eye in two ways. Firstly it provides lubricating and hydrating protective shield on the ocular surface of the eye and then it works below the tear film to provide protection to the cornea.

Trade Name Eyedew
Generic Carboxymethylcellulose + Glycerin
Weight 0.5%+0.9%
Type Eye Drops
Therapeutic Class Drugs for Dry eyes
Manufacturer Acme Laboratories Limited
Available Country Bangladesh
Last Updated: September 19, 2023 at 7:00 am
Eyedew
Eyedew

Uses

This Sterile Eye Drops is used for the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun.

Eyedew is also used to associated treatment for these conditions: Dry Eyes, Ocular IrritationCold Sore, Constipation, Dry Mouth, Dry Skin, Dry throat, Edema of the cerebrum, Hypertension Intracranial, Occasional Constipation, Ocular Discomfort, Ocular Hypertension, Ocular Irritation, Skin Infections, Sore Throat, Mouth soreness, Ocular burning, Bowel preparation therapy, Topical Antisepsis, Skin protection

How Eyedew works

Carboxymethylcellulose binds to the surface of corneal epithelial cells via its glucopyranose subunits binding to glucose receptors GLUT-1 . The residence time of carboxymethylcellulose bound to corneal cells is approximately 2 hours as indicated by a short-term binding assay . Binding of carboxymethylcellulose to the matrix proteins stimulated corneal epithelial cell attachment, migration, and re-epithelialization of corneal wounds .

When administered rectally, glycerin exerts a hygroscopic and/or local irritant action, drawing water from the tissues into the feces and reflexively stimulating evacuation. Glycerin decreases intraocular pressure by creating an osmotic gradient between the blood and intraocular fluid, causing fluid to move out of the aqueous and vitreous humors into the bloodstream.

Dosage

Eyedew dosage

Instill 1 drop in the affected eyes as needed.It can be used in children.

Side Effects

Vision may be temporarily blurred when this product is first used. Also, minor burning/ stinging/ irritation may temporarily occur.

Toxicity

Rat oral LD50, rabbit dermal LD50, and rat inhalation LC50 of sodium carboxymethyl cellulose are 27000 mg/kg, >2 g/kg, and >5800 mg/m^3 (4 hours), respectively .

Glycerol has very low toxicity when ingested ; Rat LD50 (oral)-12600mg/kg Mice LD50 (oral )-4090mg/kg Human TDLo (oral) - 1428mg/kg

Precaution

Consult doctor if irritation, eye pain or visual changes worsen or persist beyond 72 hours.

Interaction

No information is available.

Volume of Distribution

No pharmacokinetic data available.

Glycerin is distributed throughout the blood. Although glycerin generally does not appear in ocular fluids, it may enter the orbital sac when the eye is inflamed, with a consequent decrease in osmotic effect.

Elimination Route

No pharmacokinetic data available.

Well absorbed orally, poorly absorbed rectally. Studies in humans and animals indicate glycerol is rapidly absorbed in the intestine and the stomach

Half Life

No pharmacokinetic data available.

30 - 45 minutes

Clearance

No pharmacokinetic data available.

Elimination Route

No pharmacokinetic data available.

Approx 7-14% of dose is excreted unchanged in the urine within 2.5 hr.

Pregnancy & Breastfeeding use

Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. Carboxymethylcellulose Sodium and Glycerin should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.

Use in lactation: Carboxymethylcellulose Sodium or Glycerin has not been measured in human milk. Caution should be exercised when the combination of Carboxymethylcellulose Sodium and Glycerin is administered to a nursing mother.

Contraindication

It is contraindicated in patients with known hypersensitivity to any ingredient of this formulation.

Special Warning

Use in children: No information available.

Use in elderly patients: No information available.

Acute Overdose

Since CMC is pharmacologically inert and not expected to be absorbed systemically, systemic effects from topical overdose are not expected from the administration of Carboxymethylcellulose sodium (Cellufresh) 0.5%. Additionally, no toxic side effects are expected should accidental systemic overdose occur.

Storage Condition

Store below 30°C. Protect from light. Do not use longer than 1 month after 1st opening. Do not freeze.

Innovators Monograph

You find simplified version here Eyedew


*** Taking medicines without doctor's advice can cause long-term problems.
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