Exelderm

Exelderm Uses, Dosage, Side Effects, Food Interaction and all others data.

Exelderm, brand name Exelderm, is a broad-spectrum anti-fungal agent available as a topical cream and solution. Exelderm nitrate, the active ingredient, is an imidazole derivative that inhibits the growth of common pathogenic dermatophytes making it an effective treatment for tinea cruris and tinea corporis infections.

The function of imidazole derivatives can be attributed to their structural resemblance to purines essential to metabolism.

Trade Name Exelderm
Availability Prescription only
Generic Sulconazole
Sulconazole Other Names Sulconazole
Related Drugs clotrimazole topical, ketoconazole topical, terbinafine, terbinafine topical, cefuroxime, cefadroxil, itraconazole, mupirocin topical, miconazole topical, Bactroban
Weight 1%,
Type Topical Cream, Topical Solution, Topical
Formula C18H15Cl3N2S
Weight Average: 397.74
Monoisotopic: 396.0021528
Groups Approved
Therapeutic Class
Manufacturer
Available Country United States,
Last Updated: September 19, 2023 at 7:00 am
Exelderm
Exelderm

Uses

Exelderm is a topical antifungal agent used for the treatment of tinea cruris, tinea corporis, and tinea versicolor caused by susceptible fungal strains.

Exelderm solution 1.0% is indicated for the treatment of tinea cruris and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, and Microsporum canis; and for the treatment of tinea versicolor. Effectiveness has not been proven in tinea pedis (athlete’s foot).

Exelderm is also used to associated treatment for these conditions: Pityriasis versicolor, Tinea Corporis, Tinea Cruris, Tinea Pedis

Toxicity

Exelderm has been shown to be embryotoxic in a study of rats given 125 times the human dose (in mg/kg) and also resulted in prolonged gestation and dystocia. There are no adequate or controlled studies in pregnant women, therefore sulconazole should only be used during pregnancy if potential benefit justifies potential risk to the fetus.

Food Interaction

No interactions found.

Elimination Route

Total sulconazole systemic absorption after topical administration was ~8.71% of the dose.

Elimination Route

About 6.70% of the dose was recovered in urine, and 2.01% in feces over a 7 day collection period. Radioactivity could be detected in both urine and feces at 7 days potentially due to a reservoir effect.

Innovators Monograph

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https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:77776
http://www.genome.jp/dbget-bin/www_bget?drug:D08535
http://www.genome.jp/dbget-bin/www_bget?cpd:C08076
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5318
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=310264896
https://www.chemspider.com/Chemical-Structure.5127.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31770
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=37319
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=77776
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1221
http://www.rxlist.com/exelderm-drug.htm
https://www.drugs.com/mtm/sulconazole-topical.html
https://en.wikipedia.org/wiki/Sulconazole
*** Taking medicines without doctor's advice can cause long-term problems.
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