Eugid Uses, Dosage, Side Effects, Food Interaction and all others data.

The mechanism of action of betahistine is known partially. Eugid has a very strong affinity as an antagonist for histamine H3 receptors and a weak affinity as an agonist for histamine H1 receptors. The active ingredient is a specific histamine agonist with virtually no H2-activity.

Eugid has two modes of action. Primarily, it has a direct stimulating (agonistic) effect on H1 receptors located on blood vessels in the inner ear. It appears to act on the precapillary sphincter in the stria vascularis of the inner ear, thus reducing the pressure in the endolymphatic space.

In addition, betahistine has a powerful antagonistic effects at H3 receptors, and increases the levels of neurotransmitters released from the nerve endings. The increased amounts of histamine released from histaminergic nerve endings stimulates H1 receptors, thus augmenting the direct agonistic effects of betahistine on these receptors. This explains the potent vasodilatory effects of betahistine in the inner ear. This explains the efficacy of betahistine in the treatment of vertigo.

Through its actions on the histamine receptors, betahistine provides relief from vertigo associated with Ménière's disease.

Trade Name Eugid
Generic Betahistine
Betahistine Other Names Betahistina, Bétahistine, Betahistine, Betahistinum
Type Tablet
Formula C8H12N2
Weight Average: 136.1943
Monoisotopic: 136.100048394
Protein binding

The plasma protein binding of betahistine is reported to be less than 5%.

Groups Approved, Investigational
Therapeutic Class Drugs used in meniere's diseases
Manufacturer Salas Pharmaceuticals Private Limited
Available Country India
Last Updated: September 19, 2023 at 7:00 am


Eugid Mesilate dilates precapiilary sphincters, increasing the blood flow in the inner ear. It controls the permeability of capillaries in the inner ear, thereby removes endolymphatic hydrops. It also improves cerebral circulation, increasing blood flow in the internal carotid artery. Thus, Eugid Mesylate is clinically useful for the relief of vertigo and dizziness.

Eugid is also used to associated treatment for these conditions: Menière's Disease

How Eugid works

Vertigo is a disturbing sensation of movement caused by dysfunction of the labyrinth (inner ear), vestibular nerve, cerebellum, brainstem, or Central Nervous System (CNS). Vestibular forms of vertigo are often accompanied by auditory dysfunctions such as hyperacusis, hearing loss, and tinnitus. In most cases, adaptive mechanisms of the CNS lead to functional recovery after episodes of vertigo, however, syndromes such as Ménière's disease tend to cause the recurrence of vertigo symptoms. This significantly impacts the quality of life and the ability to carry out daily activities.

H1-receptor activity

The mechanism of action of betahistine is multifactorial. Ménière's disease is thought to result from a disruption of endolymphatic fluid homeostasis in the ear. Eugid mainly acts as a histamine H1-receptor agonist. The stimulation of H1-receptors in the inner ear causes a vasodilatory effect leading to increased permeability of blood vessels and a reduction in endolymphatic pressure; this action prevents the rupture of the labyrinth, which can contribute to the hearing loss associated with Ménière's disease. Eugid is also purported to act by reducing the asymmetrical functioning of sensory vestibular organs and increasing vestibulocochlear blood flow, relieving symptoms of vertigo.

H3-receptor activity

In addition to the above mechanisms, betahistine also acts as a histamine H3-receptor antagonist, increasing the turnover of histamine from postsynaptic histaminergic nerve receptors, subsequently leading to an increase in H1-agonist activity. H3-receptor antagonism elevates levels of neurotransmitters including serotonin in the brainstem, inhibiting the activity of vestibular nuclei, thus restoring proper balance and decreasing vertigo symptoms.


Eugid dosage

Usually for adults, administer orally 6 mg to 12 mg three times per day after meals. The dose may be adjusted according to the age of patient and severity of symptoms.

Side Effects

Nausea or vomiting may rarely occur. Hypersensitivity reactions, such as skin rash, may rarely occur.


Symptoms of an overdose with betahistine (< 640 mg) include dry mouth, nausea, dyspepsia, abdominal pain, and somnolence. Serious complications such as convulsions, pulmonary or cardiac effects may occur with higher doses (> 640 mg), especially during intentional overdoses and combination with other drugs. In the case of an overdose with betahistine, provide supportive therapy, and contact the local poison control center for further management.


Patients with a history of digestive ulcer or an active digestive ulcer, Patients with bronchial asthma, Patients with pheochromocytoma.

Food Interaction

  • Take with food. This may reduce or prevent gastrointestinal upset.

Volume of Distribution

In a pharmacokinetic study of rats, betahistine was found to be distributed throughout the body. Human data for betahistine's volume of distribution is not readily available.

Elimination Route

When given orally, betahistine is rapidly and almost completely absorbed from the gastrointestinal tract. In the fasted state, Cmax is achieved within 1 hour of administration; in the fed state, Cmax is delayed, but the total drug absorption is similar. Food, therefore, has little effect on the absorption of betahistine.

Half Life

The half-life of betahistine is 3-4 hours.

Elimination Route

Eugid is mainly excreted in the urine; with approximately 85-91% being detected in urine samples within 24 hours of administration.

Pregnancy & Breastfeeding use

Safety of Eugid during pregnancy has not been established. This drug should be administered to pregnant patients or women suspected of being pregnant, only if the expected therapeutic benefit is thought to outweigh any possible risk.


Hypersensitivity to betahistine mesylate, pheochromocytoma, peptic ulcer, acute bronchial asthma.

Storage Condition

Store in cool and dry place. Protect from light & moisture.

Innovators Monograph

You find simplified version here Eugid


What is Eugid used for?

Eugid is a medicine used to treat the symptoms of Ménière's disease. Symptoms include: dizziness (vertigo) ringing in the ears (tinnitus). Eugid is an anti-vertigo medication. It is commonly prescribed for balance disorders or to alleviate vertigo symptoms.

How safe is Eugid?

Eugid is unlikely to do you any harm, even if you take it for a long time. It is generally a very safe medicine.

How does Eugid work?

Eugid works by increasing the effect of a natural substance called histamine in your inner ear. Antihistamines work by stopping histamine affecting the cells in your body.

What are the common side effects of Eugid?

Common side effects of Eugid are Headache, occasional drowsiness, nausea, indigestion, mild gastric complaints such as vomiting, stomach pain and bloating.

Is Eugid safe during pregnancy?

Eugid is not usually recommended during pregnancy .

Is Eugid safe during breastfeeding?

Eugid is not usually recommended while breastfeeding.

Can I drink alcohol with Eugid?

Yes, you can drink alcohol while taking Eugid. However, some people say that their symptoms of Ménière's disease improve when they stop drinking alcohol.

Can I drive after taking Eugid ?

Eugid is not likely to affect your ability to drive or ride a bike. However, do not drive if you feel dizzy or if you feel an attack of vertigo coming on.

How long does Eugid stay in my system?

Eugid comes in both a tablet form as well as an oral solution, and is taken orally. The mean plasma elimination half-life is 3 to 4 hours, and excretion is virtually complete in the urine within 24 hours.

When should be taken of Eugid?

 It's best to take your tablets with or after food. This way it's less likely to upset your stomach.

Does Eugid cure vertigo?

Our findings suggest that Eugid therapy is effective in treating vertigo in routine clinical settings.

Can I take Eugid for a long time?

Eugid is unlikely to do you any harm, even if you take it for a long time. It is generally a very safe medicine.

How long can I take Eugid?

Your doctor may advise a trial of  Eugid for 6-12 months to see if it helps to reduce your symptoms. If it does, it can then be continued.

Who should not take Eugid?

Eugid dihydrochloride tablets are not recommended for use in children and adolescents below 18 years of ages, as there are no data on efficacity and safety in these age groups.

Can I suddenly stop taking Eugid?

Do not give this medicine to anyone else, even if they have the same condition as you. Do not stop taking Serc, or change the dosage, without checking with your doctor.

What happens if I miss a dose of Eugid?

If you forget to take a dose of Eugid, take it as soon as you remember. Unless it's less than 2 hours until your next dose. In which case, skip the missed dose and take your next dose at the usual time. Do not take 2 doses at the same time.

What happens if I take too much Eugid?

The symptoms of Eugid overdose are nausea, vomiting, dyspepsia, ataxia and seizures at higher doses. A few overdose cases have been reported. Some patients experienced mild to moderate symptoms with doses up to 640 mg.

Can Eugid affect my fertility ?

There's no firm evidence to suggest that taking Eugid will reduce fertility in either men or women. However, speak to a pharmacist or your doctor before taking it if you're trying to get pregnant.

Does Eugid cause hypertension?

As Eugid is a synthetic analogue of histamine it may induce the release of catecholamines from the tumor resulting in severe hypertension.

Can Eugid affect liver?

Eugid has a strong first pass effect and is metabolised in the liver into three metabolites, not only Eugid but also its major metabolite aminoethylpyridine increases cochlear blood flow.

*** Taking medicines without doctor's advice can cause long-term problems.