Ethchlorvynol Uses, Dosage, Side Effects, Food Interaction and all others data.

Ethchlorvynol is a sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists.

Ethchlorvynol is a sedative drug and schedule IV (USA) controlled substance. It produces cerebral depression, however the exact mechanism of action is not known.

Trade Name Ethchlorvynol
Availability Discontinued
Generic Ethchlorvynol
Ethchlorvynol Other Names etclorvinol, Ethchlorvynol
Related Drugs amitriptyline, lorazepam, melatonin, zolpidem, diphenhydramine, Ativan
Type Oral
Formula C7H9ClO
Weight Average: 144.6
Monoisotopic: 144.0341926
Protein binding


Groups Approved, Illicit, Withdrawn
Therapeutic Class
Available Country United States
Last Updated: September 19, 2023 at 7:00 am


Ethchlorvynol is a sedative hypnotic agent used for the short-term management of insomnia.

Used for short-term hypnotic therapy in the management of insomnia for periods of up to one week in duration; however, this medication generally has been replaced by other sedative-hypnotic agents.

How Ethchlorvynol works

Although the exact mechanism of action is unknown, ethchlorvynol appears to depress the central nervous system in a manner similar to that of barbiturates. Barbiturates bind at a distinct binding sites associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.


Symptoms of overdose include thrombocytopenia.

Food Interaction

  • Avoid alcohol.
  • Take with food. Food reduces irritation.

[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.

Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.

Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Elimination Route

Rapidly absorbed from gastrointestinal tract.

Half Life

Plasma half-life is approximately 10 to 20 hours, terminal half-life is 21-100 hours.

Innovators Monograph

You find simplified version here Ethchlorvynol

*** Taking medicines without doctor's advice can cause long-term problems.