Epidophyllotoxin

Epidophyllotoxin Uses, Dosage, Side Effects, Food Interaction and all others data.

Epidophyllotoxin is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Epidophyllotoxin inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Epidophyllotoxin acts primarily in the G2 and S phases of the cycle.

Epidophyllotoxin is a phase-specific cytotoxic drug, acting in the late S or early G 2 phase of the cell cycle. Epidophyllotoxin prevents cell mitosis by causing single and double stranded DNA breaks as well as cross linking between protein and DNA.

Table Of contents

• Epidophyllotoxin
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Epidophyllotoxin
Availability	Discontinued
Generic	Teniposide
Teniposide Other Names	Epidophyllotoxin, Teniposid, Téniposide, Teniposide, Teniposido, Teniposidum
Related Drugs	prednisone, methotrexate, rituximab, Rituxan, doxorubicin, cyclophosphamide, Deltasone, imatinib, Gleevec, vincristine
Type
Formula	C32H32O13S
Weight	Average: 656.654 Monoisotopic: 656.1563618
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Epidophyllotoxin is a cytotoxic drug used as an adjunct for chemotherapy induction in the treatment of refractory childhood acute lymphoblastic leukemia.

Epidophyllotoxin is used for the treatment of refractory acute lymphoblastic leukaemia

Epidophyllotoxin is also used to associated treatment for these conditions: Acute Lymphoblastic Leukaemia Recurrent, Mild Atopic dermatitis, Moderate Atopic dermatitis, Refractory Atopic dermatitis

How Epidophyllotoxin works

The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA. Epidophyllotoxin binds to and inhibits DNA topoisomerase II. The cytotoxic effects of teniposide are related to the relative number of double-stranded DNA breaks produced in cells, which are a reflection of the stabilization of a topoisomerase II-DNA intermediate.

Food Interaction

• Exercise caution with grapefruit products. Epidophyllotoxin is a CYP3A4 substrate, and grapefruit inhibits CYP3A4 metabolism, coadministration may increase the serum concentrations of teniposide.
• Exercise caution with St. John's Wort. Epidophyllotoxin is a CYP3A4 substrate, and St. John's Wort induces CYP3A4 metabolism, coadministration may reduce the serum concentrations of teniposide.

Epidophyllotoxin Disease Interaction

Major: infections, myelosuppressionModerate: hepatic dysfunction, renal dysfunction

Half Life

5 hours

Clearance

• 10.3 mL/min/m2

Elimination Route

From 4% to 12% of a dose is excreted in urine as parent drug. Fecal excretion of radioactivity within 72 hours after dosing accounted for 0% to 10% of the dose.

Innovators Monograph

You find simplified version here Epidophyllotoxin