Endoprost

Endoprost Uses, Dosage, Side Effects, Food Interaction and all others data.

Carboprost is a synthetic prostaglandin analogue of PGF2α that acts to increase the contractions of the uterus (womb) and can trigger abortion in early pregnancy. This also helps to control excessive bleeding after delivery.

Carboprost tromethamine administered intramuscularly stimulates in the gravid uterus myometrial contractions similar to labor contractions at the end of a full term pregnancy. Whether or not these contractions result from a direct effect of carboprost on the myome-trium has not been determined. Nonetheless, they evacuate the products of conception from the uterus in most cases. Postpartum, the resultant myometrial contractions provide hemostasis at the site of placentation. Carboprost tromethamine also stimulates the smooth muscle of the human gastrointestinal tract. This activity may produce the vomiting or diarrhea or both that is common when carbo-prost tromethamine is used to terminate pregnancy and for use postpartum. In laboratory animals and also in humans carboprost tromethamine can elevate body temperature. With the clinical doses of carboprost trometh-amine used for the termination of pregnancy, and for use postpartum, some patients do experience transient temperature increases. In laboratory animals and in humans large doses of carboprost tromethamine can raise blood pressure, probably by contracting the vascular smooth muscle. With the doses of carboprost tromethamine used for terminating pregnancy, this effect has not been clinically significant. In laboratory animals and also in humans carboprost tromethamine can elevate body temperature. With the clinical doses of carboprost tromethamine used for the termination of pregnancy, some patients do experience temperature increases. In some patients, carboprost tromethamine may cause transient bronchoconstriction.

Trade Name Endoprost
Generic Carboprost Tromethamine
Carboprost Tromethamine Other Names Carboprost trometamol, Carboprost tromethamine
Type Injection, Solution
Formula C25H47NO8
Weight Average: 489.65
Monoisotopic: 489.330167477
Groups Approved
Therapeutic Class Drugs acting on the Uterus
Manufacturer Bharat Serums & Vaccines Ltd, Bharat Serums & Vaccines Ltd,
Available Country India, Philippines
Last Updated: September 19, 2023 at 7:00 am
Endoprost
Endoprost

Uses

Terminating pregnancy between the 13th and 20th weeks of gestationIn the following conditions related to second trimester abortion:

1. Failure of expulsion of the fetus during the course of treatment by another method;

2. Premature rupture of membranes in intrauterine methods with loss of drug and insufficient or absent uterine activity;

3. Requirement of a repeat intrauterine instillation of drug for expulsion of the fetus;

4. Inadvertent or spontaneous rupture of membranes in the presence of a previable fetus and absence of adequate activity for expulsion.

Treatment of postpartum hemorrhage due to the uterus failing to return to its normal size and who have not responded to conventional treatments.

Endoprost is also used to associated treatment for these conditions: Refractory postpartum uterine hemorrhage, Medically induced abortion

How Endoprost works

Carboprost is a synthetic prostaglandin. It binds the prostaglandin E2 receptor, causing myometrial contractions, casuing the induction of labour or the expulsion of the placenta. Prostaglandins occur naturally in the body and act at several sites in the body including the womb (uterus). They act on the muscles of the womb, causing them to contract.

Dosage

Endoprost dosage

1. Abortion and Indications 1–4An initial dose of 1 ml of Carbestop (containing the equivalent of 250 mcg of Carboprost) is to be administered intramuscularly. Subsequent doses of 250 mcg should be administered at 1½ to 3½ hour intervals depending on uterine response. An optional test dose of 100 mcg (0.4 ml) may be administered initially. The dose may be increased to 500 micrograms (2 ml) if uterine contractility is judged to be inadequate after several doses of 250 mcg (1 ml). The total dose administered of Carbestop should not exceed 12 mg and continuous administration of the drug for more than 2 days is not recommended.

2. For Refractory Postpartum Uterine Bleeding:An initial dose of 250 mcg of Carbestop (1 ml) is to be given deep, intramuscularly (IM). If needed the dose of 1 ml may be repeated between 15 to 90 minutes. The total dose of Carbestop should not exceed 2 mg (8 doses).

Side Effects

The most frequent adverse reactions observed are related to its contractile effect on smooth muscle, especially gastrointestinal effects like vomiting, nausea, diarrhea and pyrexia. Endometritis, retained placental fragments, and excessive uterine bleeding occurred as the most common complications after abortion with Carboprost.

Toxicity

Symptoms of overdose include irritation, nausea, vomiting, diarrhea, coughing, dyspnea, asthma, hypertension, flushing, and pyrexia.

Precaution

• Use Carboprost by medically trained personnel in a hospital which can provide immediate intensive care and acute surgical facilities.

• Use Carboprost cautiously in patients with a history of asthma, hypo- or hypertension, cardiovascular, renal or hepatic disease, anemia, jaundice, diabetes or epilepsy and compromised (scarred) uteri.

• In few patients with chorioamnionitis, uterus may not respond to Carboprost.

• Cervix should always be carefully examined immediately post-abortion.

Interaction

Carboprost may augment the activity of other oxytocic agents. Concomitant use with other oxytocic agents is not recommended.

Food Interaction

No interactions found.

Pregnancy & Breastfeeding use

Pregnancy category C. Animal studies do not indicate that Carboprost is teratogenic, however, it has been shown to be embryotoxic in rats and rabbits and any dose which produces increased uterine tone could put the embryo or fetus at risk.

Contraindication

  • Hypersensitivity (including anaphylaxis and angioedema) to Carboprost Sterile Solution
  • Acute pelvic inflammatory disease
  • Patients with active cardiac, pulmonary, renal or hepatic disease

Storage Condition

Store at 2-8°C. Do not freeze. Keep away from light. Once the ampoule has been opened, the product should be used immediately.

Innovators Monograph

You find simplified version here Endoprost

*** Taking medicines without doctor's advice can cause long-term problems.
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