Elo Tablet

Elo is a non-sedating antihistamine. It works by selectively binding to peripheral histamine H1-receptors on effector cells.

Uses

Elo provides faster relief from the symptoms of hay fever, allergic rhinitis such as sneezing, nasal discharge, itching, ocular itching and burning, nasal and ocular sign and symptoms are relieved rapidly after oral administration. 

Elo is also effective in idiopathic chronic urticaria. In children over 2 years, Elo is used for the symptomatic relief of seasonal allergic rhinitis and allergic skin conditions such as urticaria nettle rash.

Elo is also used to associated treatment for these conditions: Allergic Dermatologic Disorders, Allergic Rhinitis (AR), Allergies, Chronic Urticaria, Common Cold, Eye pruritus, Fever, Nasal Congestion, Nasal Itching, Pain, Perennial Allergic Rhinitis (PAR), Perennial Rhinitis, Pollen Allergy, Pruritus, Rhinorrhoea, Seasonal Allergic Rhinitis, Sneezing, Sensation of burning in the eyes, Watery eyes, Watery itchy eyes

Trade Name Elo
Generic Loratadine
Other Names Loratadina, Loratadine, Loratadinum
Weight 10mg
Type Tablet
Formula C22H23ClN2O2
Weight Average: 382.883
Monoisotopic: 382.144805697
Protein binding

97 - 99% of the loratadine is bound to plasma proteins.

Therapeutic Class Non-sedating antihistamines
Manufacturer Edruc Ltd, Nutraceuticals
Available Country Bangladesh, India
Last Updated: June 23, 2021 at 11:22 am

Dosage

Elo dosage

Adult & children over 12 years of age: One Elo 10 mg tablet once daily (usually in the morning).

Children

  • 2-12 years (body weight more than 30 Kg): 10 mg Elo once daily.
  • 2-12 years (body weight less than 30 Kg): 5 mg Elo once daily.
  • Below 2 years of age: Safety and efficacy of Elo have not been established.

Liver & renal impairment: Patients with liver impairment and renal insufficiency (GFR <30 ml/min) should be given a lower initial dose (10 mg every other day).

Side Effects

Fatigue, nausea and headache were reported rarely. Scientific studies showed that Elo does not cause drowsiness. It does not affect performance and ability to drive or tasks requiring concentration.

Precaution

Patients with liver impairment and renal insufficiency (GFR <30 ml/min) should be given a lower initial dose (10 mg every other day).

Interaction

When administered concurrently with alcohol, Elo has no potentiating effect as measured by psychomotor performance studies. Interactions with other drugs have not been reported.

Food Interaction

No interactions found.

Volume of Distribution

The volume of distribution of loratadine is 120 L/Kg.

Half Life

The elimination half life is approximately 10 hours for loratadine and 20 hours for descarboethoxyloratadine.

Clearance

The clearance of loratadine after single oral doses of 20 mg and 40 mg are 12 L/h/kg and 9 L/h/kg respectively. P-glycoprotein is involved in the clearance of many 2nd generation antihistamines, including loratadine, from the central nervous system. 1st generation antihistamines are not cleared by P-glycoprotein, which may help explain why they have a different central nervous system adverse effect profile compared to their 2nd generation counterparts. It appears that an antihistamine with higher affinity for p-glycoprotein will have a lower incidence of CNS adverse effects.

Pregnancy & Breastfeeding use

Use in pregnancy: There is no experience of the use of Elo in human pregnancy, hence it should not be used during pregnancy.

Use in lactation: Elo is excreted in breast milk, so it should not be administered to lactating mother.

Contraindication

Elo is contraindicated in patients who have shown hypersensitivity or idiosyncracy to their components.

Acute Overdose

Symptoms: Somnolence, tachycardia headache, drowsiness, extrapyramidal manifestations and palpitations. 

Management: Symptomatic and supportive treatment. Immediately empty stomach by inducing emesis with ipecac syrup. Admin of activated charcoal after emesis may be useful. If induction of vomiting is unsuccessful or contraindicated (e.g. patient is comatose, having seizures or lacks gag reflex), gastric lavage with NaCl 0.9% soln may be performed to prevent aspiration of gastric contents. Saline cathartics may be useful to rapidly dilute bowel contents.

Storage Condition

Store between 20-25° C.

Elo contains Loratadine see full prescribing information from innovator Monograph