Doxacurium chloride

Doxacurium chloride Uses, Dosage, Side Effects, Food Interaction and all others data.

Doxacurium chloride chloride is a long-acting, nondepolarizing skeletal muscle relaxant for intravenous administration.

Doxacurium chloride chloride is a long-acting, nondepolarizing skeletal muscle relaxant. The neuromuscular block produced by doxacurium chloride may be antagonized by anticholinesterase agents. As with other nondepolarizing neuromuscular blocking agents, the more profound the neuromuscular block at reversal, the longer the time and the greater the dose of anticholinesterase required for recovery of neuromuscular function. Doxacurium chloride chloride is approximately 2.5 to 3 times more potent than pancuronium and 10 to 12 times more potent than metocurine.

Doxacurium chloride
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Doxacurium chloride
Availability	Discontinued
Generic	Doxacurium
Doxacurium Other Names	Doxacurium chloride
Type
Formula	C₅₆H₇₈N₂O₁₆
Weight	Average: 1035.2223 Monoisotopic: 1034.535134458
Protein binding	Approximately 30%.
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Doxacurium chloride chloride is a nondepolarizing neuromuscular blocking agent used as an adjunct to general anesthesia to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgical procedures.

Used to provide skeletal muscle relaxation as an adjunct to general anesthesia, for endotracheal intubation or to facilitate mechanical ventilation.

How Doxacurium chloride works

Doxacurium chloride chloride binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission (non-depolarizing). This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine.

Toxicity

Overdosage with neuromuscular blocking agents may result in neuromuscular block beyond the time needed for surgery and anesthesia.

Doxacurium chloride Drug Interaction

Unknown: zafirlukast, zafirlukast, ipratropium, ipratropium, albuterol / ipratropium, albuterol / ipratropium, formoterol / mometasone, formoterol / mometasone, albuterol / ipratropium, albuterol / ipratropium, fluticasone, fluticasone, pentamidine, pentamidine, budesonide, budesonide, dornase alfa, dornase alfa, zanamivir, zanamivir

Doxacurium chloride Disease Interaction

Major: prematurity, burns, electrolyte imbalance, liver disease, myasthenia gravis, paresis, pulmonary impairModerate: obesity, renal dysfunction

Volume of Distribution

0.11-0.43 L/kg [Healthy Young Adult Patients]
0.17-0.55 L/kg [Kidney Transplant Patients]
0.17-0.35 L/kg [Liver Transplant Patients]

Half Life

99 minutes in normal healthy adults.

Clearance

2.66 mL/min/kg [Healthy Young Adult Patients]
1.23 mL/min/kg [Kidney Transplant Patients]
2.3 mL/min/kg [Liver Transplant Patients]
1.75 +/- 0.16 mL/min/kg [Elderly patients (70-83 yrs)]
2.54 +/- 0.24 mL/min/kg [younger patients (19-39 yrs)]

Elimination Route

In vivo data from humans suggest that NUROMAX is not metabolized and that the major elimination pathway is excretion of unchanged drug in urine and bile.