Domilin

Domilin Tablet, Oral Suspension

Domilin is dopamine receptor (D2) antagonist which selectively inhibits dopamine at the D2 receptor. It acts principally at receptors in the chemoreceptor trigger zone (CTZ) and also at receptors in the stomach.

Uses

Stimulation of gut motility in-

  • Non-ulcer dyspepsia
  • Oesophageal reflux, reflux oesophagitis and gastritis
  • Diabetic gastroparesis
  • Functional dyspepsia
  • Speeding barium transit in follow through radiological studies

Prevention and symptomatic relief of acute nausea and vomiting from any cause including cytotoxic therapy, radiotherapy and antiparkinsonism therapy.

In the prophylactic treatment of migraine.

Domilin is also used to associated treatment for these conditions: Diabetic Gastroparesis, Dyspepsia, Erosive Esophagitis, Gastrointestinal Symptoms, Non-erosive Reflux Esophagitis Disease (NERD), Upper gastrointestinal motility disorders

Domilin

Trade Name Domilin
Generic Domperidone
Domperidone Other Names Domperidona, Domperidone, Domperidonum
Weight 10mg, 5mg/ 5ml
Type Tablet, Oral Suspension
Formula C22H24ClN5O2
Weight Average: 425.911
Monoisotopic: 425.161852744
Protein binding

91%-93%

Therapeutic Class Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs
Manufacturer General Pharmaceuticals Ltd
Available Country Bangladesh
Last Updated: June 23, 2021 at 11:19 am

Structure

Domilin
Domperidone Structure

Dosage

Domilin dosage

Adults: 10 - 20 mg every 4 - 8 hours daily

Children: 0.2 - 0.4 mg/kg every 4 - 8 hours daily.

Domilin tablet and suspension should be taken 15 - 30 minutes before a meal.  For acute nausea and vomiting, maximum period of treatment is 12 weeks.

Side Effects

Domilin may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness and reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash and itching.

Precaution

Domilin should be used with absolute caution in case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood brain barrier.

Interaction

Domilin may reduce the hypoprolactinaemic effect of bromocriptine. Anti-muscarinics and opioid analgesics may antagonize the action of Domilin on gastrointestinal function.

Food Interaction

  • Take before a meal. Take 15-30 minutes before meals.

Half Life

7 hours

Pregnancy & Breastfeeding use

Use in pregnancy: The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy. 

Use in lactation: Domilin may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.

Contraindication

Domilin is contraindicated to the patients who have hypersensitivity to this drug and in case of neonates.

Acute Overdose

Overdose has been reported primarily in infants and children. Symptoms of overdosage may include disorientation, somnolence and extrapyramidal reactions. There is no specific antidote to domperidone, but in the event of overdose, the administration of activated charcoal may be useful. Anticholinergics, antiparkinson drugs may be useful in controlling extrapyramidal reactions. The patient should be observed closely and supportive measures employed.

Storage Condition

Store in a cool dry place protected from light. Keep out of reach of children.

Innovators Monograph

Domilin contains Domperidone see full prescribing information from innovator // generic/domperidone/domperidone-maleate-suppository-prescribing-information" Monograph

FAQ

what is Domilin used for?

Domilin help to stop feeling or being sick like as nausea or vomiting.It can also be used to treat stomach pain if you're having end of life care (palliative care). Domilin is sometimes used to increase milk supply.Domilin is an anti-sickness medicine.

Is Domilin safe to take?

For most people, taking Domilin is safe.If you have heart problems or are taking other medicines, you should first check with your healthcare professional that this medicine is appropriate.

What are the side effects of Domilin?

Side Effects

  • swelling of the ankles/feet.
  • unusual tiredness.
  • mental/mood changes (e.g., nervousness, irritability)
  • hot flashes.
  • breast swelling/pain.
  • unusual leakage of milk from the breast.
  • changes in menstrual periods.
  • decreased sexual ability.

Is Domilinsafe during pregnancy?

Domilin is not usually recommended in pregnancy.

Why Domilin is not safe in pregnancy?

Domilin is contraindicated for use in pregnant women and in women suspected of being pregnant, due to teratogenicity observed in reproductive toxicity studies.

Is Domilin safe during breastfeeding?

A very small amount of the Domilin you take can pass into your breast milk, but there is no record of harmful side effects in the baby from the mother taking Domilin.

Can I drink alcohol with Domilin?

It is best to avoid alcohol when taking Domilin. Drinking alcohol can make side effects worse, such as sleepiness or an irregular heartbeat.

How long does Domilin take to work?

Domilin often takes at least three or four days before you notice any effect. It usually takes about two weeks to get a maximum effect, but some find it takes even longer.

Can I take Domilin before bed?

Domilin is best taken 15 to 30 minutes before meals and id necessary at bedtime.

Is Domilin good for acid reflux?

It decreases postprandial reflux time and is therefore used to treat regurgitation and vomiting.

Can I take Domilin after eating?

Domilin is best taken about 15 to 30 minutes before meals, with a glass of water. If you take Domilin after a meal, it will still work, but it may take longer to have an effect.

Is Domilin good for gastritis?

Domilin has a good advantage in the treatment of reflux gastritis and is more effective than conventional treatment.Domilin is a kind of drug to strengthen gastric motility.

What does Domilin do to your body?

Domilin is a medicine that increases the movements or contractions of the stomach and bowel. Domilin is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease.

Is Domilin safe for kidneys?

Domilin are not significantly renally cleared and can be used in CKD.

Does Domilin help anxiety?

Domilin is used to treat severe anxiety like as emotional state where you may sweat, tremble, feel anxious and have a fast heartbeat or agitation.

Does Domilin raise blood pressure?

Domilin increases blood pressure and heart rate without inducing nocturnal hypertension in apomorphine treated patients with idiopathic Parkinson's disease.

Is Domilin a narcotic?

Domilin is not a controlled substance, e.g. sleeping pills, Valium, narcotics..

Does Domilin cause depression?

Domilin can cause central nervous system side effects such as fatigue, irritability, or depression.

Can I take Domilin for a long time?

You should usually take Domilin for up to a week.Because Domilin can cause an irregular heartbeat if you take it for longer or at a high dose.

What happens when I stop taking Domilin?

Most women do not experience discomfort when stopping the medication, gradual weaning from the medication will help the mother's milk supply to adjust without frustrating the baby or causing her discomfort. It is very important to stop the Domilin slowly.