Din Tablet, Injection

Din has antispasmodic effect mediated via inhibition of phosphodiesterase-IV, specific for smooth muscle. It has a rapid and direct action on the smooth muscle. It acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain.

Uses

Spastic conditions of the gastrointestinal tract, irritable bowel syndrome-

  • Biliary colics and spastic conditions of the biliary tract: Cholecystolithiasis, cholecystitis, cholangitis.
  • Renal colics and spastic conditions of the urogenital tract: Nephrolithiasis, ureterolithiasis, pyelitis, cystitis.
  • Spastic conditions of the uterus: Dysmenorrhea, imminent abortion, uterine tetanus.

Din is also used to associated treatment for these conditions: Abdominal Pain caused by Gall Stones, Abdominal Pain caused by Kidney Stones, Muscle Spasms, Spastic Pain, Spastic Pain caused by Cystitis, Spastic Pain caused by Funicular Nephritis, Spastic Pain caused by Gallbladder disorders, Spastic Pain caused by Physical Examination, Spastic Pain caused by cholecysitis, Spastic Pain of the Gastrointestinal Tract

Trade Name Din
Generic Drotaverine
Other Names Drotaverin, Drotaverina, Drotaverine, Drotaverinum
Weight 10mg
Type Tablet, Injection
Formula C24H31NO4
Weight Average: 397.5072
Monoisotopic: 397.225308485
Protein binding

There is no information available.

Therapeutic Class Anticholinergics
Manufacturer Mapra Laboratories Pvt Ltd, Millat Pharmaceuticals Limited
Available Country India, Bangladesh
Last Updated: June 23, 2021 at 9:00 am

Dosage

Din dosage

Oral-

  • Adults: 1 to 2 tablets, 3 times daily
  • Children (over 6 years): 1/2 to 1 tablet, 1-2 times daily.
  • Children (1-6 years): 1/4 to 1/2 tablet, 1-2 times daily.

Injection-

  • Adults: 1 to 2 ampoules, intramuscularly or subcutaneously, 1-3 times daily.
  • For the management of acute stone colics: 1 or 2 ampoules by slow intravenous injection.

Side Effects

The common side effects are headache, dizziness, rhinitis, sinusitis, gastrointestinal upset, nausea, pharyngitis, edema and fatigue.

Precaution

Caution should be taken for patients suffering from liver and kidney disease.

Interaction

May attenuate the action of levodopa. Concurrent use of analgesics, antimuscarinics or benzodiazepines. Additive beneficial effect with concurrent use of analgesics, antimuscarinics or benzodiazepines.

Food Interaction

No interactions found.

Volume of Distribution

Following oral administration of a single 80 mg dose, the mean volume of distribution was 193 ± 48 L. Following an intravenous dose of 80 mg, the mean volume of distribution was 195 ± 48 L.

Half Life

Following oral administration of a single 80 mg dose, the mean half-life was 9.11 ± 1.29 hours. Following an intravenous dose of 80 mg, the mean half-life 9.33 ± 1.02 hours.

Clearance

Following oral administration of a single 80 mg dose, the mean renal clearance was 0.59 ± 0.18 mL/min. Following an intravenous dose of 80 mg, the mean renal clearance was 0.73 ± 0.29 mL/min.

Pregnancy & Breastfeeding use

As with most drugs, the use of Din Hydrochloride should be avoided during pregnancy and lactation unless essential.

Contraindication

Din is contraindicated in patients with known hypersensitivity to the products and its constituents.

FAQ

What is Din?

Din (INN, Drotaverine also known as drotaverin) is an antispasmodic drug, used to enhance cervical dilation during childbirth. It is structurally related to papaverine, is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects.

What is Din used for?

Din is used to treat menstrual pain and abdominal pain. It relieves pain due to smooth muscle spasms, such as menstrual pain, kidney stone pain, biliary stone pain, and gastrointestinal colic pain.

Is Din a painkiller?

It relieves pain due to smooth muscle spasm like menstrual pain, pain due to kidney stone, pain due to biliary stone and gastro-intestinal colicky pain. Din is an anti-spasmodic medicine which relieves contractions (spasms) associated with smooth muscles in the abdomen.

Is Din safe?

Din is an effective and safe pharmaceutical agent in the management of recurrent abdominal pain.

How to take Din?

Take Din in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Din Tablet may be taken with or without food, but it is better to take it at a fixed time.

Is Din safe in pregnancy?

Due to the lack of safety information, Din should not be used during pregnancy until prescribed.

What are the side effects of Din?

Din side effects are:

  • Nausea
  • Vomiting
  • Dry mouth
  • Change in pulse rate
  • Dizziness
  • Headache
  • Difficulty in breathing
  • Skin allergic
  • Swelling of face, lips, eyelids and tongue
  • Fall in Blood pressure
  • Vertigo
  • Constipation
  • Sleep disorders
  • Dermatitis

What is the indication of Din?

The indications to Din administration include contractions of the biliary ducts, urinary tract, and digestive smooth muscles; also dysmenorrhea and imminent abortion.

Is Din a steroid?

Din is an anti-spasmodic medicine which relieves contractions (spasms) associated with smooth muscles in the abdomen.

Is Din safe in children?

Din is an effective and safe pharmaceutical agent in the management of recurrent abdominal pain in children.

How long does Din take to work?

You should take Din for the treatment as prescribed by the doctor. However, if there is no improvement in pain after seven days, consult your doctor.

Why Din is given in pregnancy?

It was concluded that Din is highly effective in reducing the duration of active phase of labour by hastening cervical dilatation, more effective when given in more dilated cervix than with less dilatation and more effective in multigravida than in primigravida.

Why Din is given?

Din is an antispasmodic medicine. It is used in the treatment of menstrual pain and abdominal pain. It provides relief from pain due to smooth muscle spasm like menstrual pain, pain due to kidney stones, pain due to biliary stone and gastrointestinal colicky pain.