Digitoxoside

Digitoxoside Uses, Dosage, Side Effects, Food Interaction and all others data.

A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)

Digitoxoside is a cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting (From Martindale, The Extra Pharmacopoeia, 30th ed, p665). It is eliminated hepatically making it useful in patients with poor or erratic kidney function, although it is now rarely used in practice. Digitoxoside lacks the strength of evidence that digoxin has in the management of heart failure.

Digitoxoside
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Digitoxoside
Availability	Discontinued
Generic	Digitoxin
Digitoxin Other Names	Digitoksin, Digitoxin, Digitoxina, Digitoxine, Digitoxinum, Digitoxoside
Type
Formula	C₄₁H₆₄O₁₃
Weight	Average: 764.9391 Monoisotopic: 764.434692134
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Digitoxoside is a cardiac glycoside used in the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.

For the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.

Digitoxoside is also used to associated treatment for these conditions: Atrial Fibrillation, Atrial Fibrillation or Flutter, Chronic Heart Failure (CHF), Flutter, Atrial, Tachyarrhythmias

How Digitoxoside works

Digitoxoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Digitoxoside also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.

Toxicity

Digitoxoside exerts similar toxic effects to digoxin including anorexia, nausea, vomiting, diarrhoea, confusion, visual disturbances, and cardiac arrhythmias.

Food Interaction

Avoid avocado. Persea americana (avocado) is a plant that affects the heart by interfering with the Na+, K+, ATPase, which may cause an additive effect with digitoxin.
Do not take with bran and high fiber foods. The absorption of digitoxin is more predictable than the absorption of digoxin in the presence of high-fiber food.