Dextrofenfluramine

Dextrofenfluramine Uses, Dosage, Side Effects, Food Interaction and all others data.

Dextrofenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn.

Used to treat diabetes and obesity, Dextrofenfluramine decreases caloric intake by increasing serotonin levels in the brain’s synapses. Dextrofenfluramine acts as a serotonin reuptake inhibitor. It also causes release of serotonin from the synaptosomes.

Trade Name Dextrofenfluramine
Availability Discontinued
Generic Dexfenfluramine
Dexfenfluramine Other Names (S)-fenfluramine, Dexfenfluramina, Dexfenfluramine, Dexfenfluraminum, Dextrofenfluramine
Related Drugs phentermine, Victoza, semaglutide, Wegovy, Saxenda, liraglutide, Contrave, Qsymia, Alli
Type
Formula C12H16F3N
Weight Average: 231.2573
Monoisotopic: 231.123484132
Protein binding

36%

Groups Approved, Illicit, Investigational, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Dextrofenfluramine
Dextrofenfluramine

Uses

For the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet

How Dextrofenfluramine works

Dextrofenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin reuptake. The increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates.

Toxicity

Symptoms of overdose include respiratory failure and cardiac arrest leading to death.

Food Interaction

  • Take with food.

[Moderate] GENERALLY AVOID: Alcohol may potentiate the central nervous system and cardiovascular effects of centrally-acting appetite suppressants.

In one study, concurrent administration of methamphetamine (30 mg intravenously) and ethanol (1 gm

This increases cardiac work and myocardial oxygen consumption, which may lead to more adverse cardiovascular effects than either agent alone.

Subjective effects of ethanol were diminished in the eight study subjects, but those of methamphetamine were not affected.

The pharmacokinetics of methamphetamine were also unaffected except for a decrease in the apparent volume of distribution at steady state.

MANAGEMENT: Concomitant use of centrally-acting appetite suppressants and alcohol should be avoided if possible, especially in patients with a history of cardiovascular disease.

Patients should be counselled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Elimination Route

Well-absorbed from the gastrointestinal tract.

Half Life

17-20 hours

Innovators Monograph

You find simplified version here Dextrofenfluramine

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0002448
http://classyfire.wishartlab.com/tax_nodes/C0002279
http://classyfire.wishartlab.com/tax_nodes/C0000186
http://classyfire.wishartlab.com/tax_nodes/C0000188
http://classyfire.wishartlab.com/tax_nodes/C0004551
http://classyfire.wishartlab.com/tax_nodes/C0002811
http://classyfire.wishartlab.com/tax_nodes/C0003899
http://classyfire.wishartlab.com/tax_nodes/C0002228
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0001517
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001027
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:439329
http://www.hmdb.ca/metabolites/HMDB0015322
http://www.genome.jp/dbget-bin/www_bget?drug:D07805
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=66265
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508388
https://www.chemspider.com/Chemical-Structure.59646.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85596
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=3268
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=439329
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL248702
https://zinc.docking.org/substances/ZINC000000000294
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP001224
http://www.pharmgkb.org/drug/PA164747936
http://www.rxlist.com/cgi/generic/dexfen.htm
https://en.wikipedia.org/wiki/Dexfenfluramine
*** Taking medicines without doctor's advice can cause long-term problems.
Share