Depiquin Forte

Depiquin Forte Uses, Dosage, Side Effects, Food Interaction and all others data.

Each gram cream contains-

Hydroquinone 40 mgOctyldimethyl P-aminobenzoate 80 mgDioxybenzone 30 mgOxybenzone 20 mgHydroquinone is a topical depigmentating agent used in hyperpigmentation conditions by suppressing melanocyte metabolic processes. It also increases melanin excretion from melanocytes and prevents its production.

Octyldimethyl P-aminobenzoate is used topically as a sunscreen. It is used to prevent sunburn, but unlikely to prevent drug-related or other photosensitivity reactions associated with UVA light.

Dioxybenzone (benzophenone-8) is an organic compound used in sunscreen to block UVB and short-wave UVA (ultraviolet) rays. It is a derivative of benzophenone. It is a yellow powder with a melting point of 68 °C. It is insoluble in water, but moderately soluble in ethanol and isopropanol.

Oxybenzone: Although benzophenones are primarily UV-B absorbers, oxybenzone absorbs well through UV-A II. Oxybenzone can be considered a broad-spectrum absorber. It significantly augments UV-B protection when used in a given formula.

Depiquin Forte
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Depiquin Forte
Generic	Hydroquinone + Octyldimethyl P-aminobenzoate + Dioxybenzone + Oxybenzone
Weight	0.4%+0.8%+0.3%+0.2%
Type	Cream
Therapeutic Class	Sunblock Preparation
Manufacturer	Unimed Unihealth MFG, Ltd
Available Country	Bangladesh
Last Updated:	September 19, 2023 at 7:00 am

Uses

Hydroquinone is used -

For the gradual bleaching of hyperpigmented skin conditions such as chloasma, melasma, freckles, senile lentigines and other unwanted areas of melanin hyperpigmentation.
To reduce hyperpigmentation caused by photosensitization associated with inflammation or with the use of certain cosmetics.

Depiquin Forte is also used to associated treatment for these conditions: SunburnAcne Vulgaris, Melasma, Skin hyperpigmentation, Moderate Melasma, Severe MelasmaSunburn

How Depiquin Forte works

Emitted by the sun, UVA-II rays, which range at 320–400 nm and are not absorbed by the ozone layer, and UVB rays, which range 290–320 nm and are partially absorbed by the ozone layer and exert a damaging effect on human skin, including basal cell carcinoma and melanoma . As a chemical filter, dioxybenzone absorb these rays to prevent their penetration into the skin and attenuate long-term skin damage caused by UV radiation from the sun. In a rat uterine cytosolic estrogen receptor (ER) competitive binding assay, dioxybenzone was not found to be a ER-binder .

Hydroquinone reduces melanin pigment production through inhibition of the tyrosinase enzyme, which is involved in the initial step of the melanin pigment biosynthesis pathway. Hydroquinone takes several months to take effect.

Oxybenzone absorbs UV-A ultraviolet rays, preventing them from reaching the skin.

Dosage

Depiquin Forte dosage

Adult: This cream should be applied to the affected area and rubbed in well twice daily or as directed by a physician. Most discolorations begin to lighten after 3 or 4 weeks of treatment but it may take longer. After desired bleaching, use only as needed to maintain results of treatment. After reduction of hyperpigmentation, use of sunscreen agents and/or protective clothing should continue on bleached skin to prevent repigmentation.

Children: Safety and efficacy in paediatric patients below the age of 12 years have not been established.

Side Effects

Transient erythema, mild burning sensations; hyperpigmentation. Staining and corneal opacities. Tremors and convulsions after systemic absorption. Occasionally, hypersensitivity.

Toxicity

No toxicokinetic data available.

Precaution

Test for skin sensitivity before using by applying a small amount to an unbroken patch of skin to check in 24 hours. Minor redness is not a contraindication, but where there is itching or vesicle formation or excessive inflammatory response, further treatment is not advised. If no bleaching or lightening effect is noted after 2 months of treatment, the medication should be discontinued.Contact with the eyes and lips should be avoided. Hydroquinone should not be applied to cut or abraded skin. Avoid contact with eyes and on abraded or sunburnt skin.

Avoid unnecessary exposure to sunlight. Limit application to area no larger than face and neck or hands and arms. Not advised to use when itching, vesicle formation, or excessive inflammation occurs. Discontinue application if there is no improvement after 2 mth of treatment.

Interaction

There are no known drug interactions and none well documented.

Volume of Distribution

No pharmacokinetic data available.

Elimination Route

Dioxybenzone is a derivative of benzophenone. In monkeys, percutaneous absorption of benzophenone was observed . Other derivatives of benzophenone are capable of crossing the skin via direct penetration through the intercellular laminae of the stratum corneum (SC) or by passive diffusion by high-concentration gradient into the systemic circulation, where they are transported to different tissues including liver and brain .

Half Life

No pharmacokinetic data available.

Clearance

No pharmacokinetic data available.

Elimination Route

No pharmacokinetic data available.

In vivo studies show oxybenzone is abosorbed transdermally (through the skin) and is excreted in the urine.

Pregnancy & Breastfeeding use

Pregnancy Category-C. It is not known whether this cream can cause fetal harm when used topically on a pregnant woman or affect reproductive capacity. It is not known to what degree, if any, topical hydroquinone is absorbed systemically. Topical hydroquinone should be used in pregnant woman only when clearly indicated.

Lactation: It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when topical hydroquinone is used by a nursing mother.

Contraindication

Hydroquinone is contraindicated to patients with prior history of hypersensitivity or allergic reaction to hydroquinone or other ingredients in the preparation. Sunburn or depilatory usage. Children <12 yr.

Acute Overdose

There have been no systemic reactions from the use of topical hydroquinone. Some patients may experience a transient reddening of skin and mild burning sensation which does not preclude treatment.