Darapladib Uses, Dosage, Side Effects and more

Attribute	Details
Trade Name	Darapladib
Generic	Darapladib
Darapladib Other Names	Darapladib
Type
Formula	C36H38F4N4O2S
Weight	Average: 666.78 Monoisotopic: 666.265160306
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	January 7, 2025 at 1:49 am

Uses

Investigated for use/treatment in atherosclerosis.

How Darapladib works

Darapladib is a selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor. Lp-PLA2 is an enzymatic upstream mediator of inflammatory processes. Evidence from experimental settings show that the breakdown products from oxidized low density lipoprotein C (LDL-C)such as lysophosphatidylcholine species and oxidized nonesterified fatty acids are pro-inflammatory and pro-apoptotic. These products are suspected to cause athlerosclerosis progression and plaque vulnerability, which leads to increased risk of cardiovascular problems.

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