Colgit Uses, Dosage, Side Effects, Food Interaction and all others data.

Colgit sulphate is a cyclopeptide antibiotic belongs to the polymixin therapeutic class and identical to polymixin E. Colgit is used for the prevention and treatment of diseases caused by sensitive bacteria in poultry and large animal. It causes disorganization of bacterial cell membrane with leakage of intracellular materials and thus inhibits bacterial oxidative metabolism. Resistance to colistin is uncommon.

Colgit is a polymyxin antibiotic agent. Polymyxins are cationic polypeptides that disrupt the bacterial cell membrane through a detergentlike mechanism. With the development of less toxic agents, such as extended-spectrum penicillins and cephalosporins, parenteral polymyxin use was largely abandoned, except for the treatment of multidrug-resistant pulmonary infections in patients with cystic fibrosis. More recently, however, the emergence of multidrug-resistant gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, and the lack of new antimicrobial agents have led to the revived use of the polymyxins.

Trade Name Colgit
Generic Colistin
Colistin Other Names Colimycin, Colistin, Colistina, Colistine, Colistinum, Kolimycin, Polymyxin E
Type Syrup
Formula C52H98N16O13
Weight Average: 1155.455
Monoisotopic: 1154.74992728
Groups Approved
Therapeutic Class Cyclopeptide Antibiotic
Manufacturer Alde Medi Impex
Available Country India
Last Updated: September 19, 2023 at 7:00 am



Colgit is also used to associated treatment for these conditions: Ear infection bacterial, External ear infection NOS

How Colgit works

Colgit is a surface active agent which penetrates into and disrupts the bacterial cell membrane. Colgit is polycationic and has both hydrophobic and lipophilic moieties. It interacts with the bacterial cytoplasmic membrane, changing its permeability. This effect is bactericidal. There is also evidence that polymyxins enter the cell and precipitate cytoplasmic components, primarily ribosomes.


Colgit dosage

Broiler, Shonali, Layer and Breeder: 1ml/2-4 liter water for 3-5 days.Cattle, Calf, Goat and sheep: 1ml/40 kg body weight twice daily for 3-5 days.Or as Directed by the registered Veterinarian.


Oral LD50 in rats is 5450 mg/kg. Overdosage with colistimethate can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorders of speech and apnea. Respiratory muscle paralysis may lead to apnea, respiratory arrest and death.



Food Interaction

No interactions found.

Elimination Route

Very poor absorption from gastrointestinal tract.

Half Life

5 hours

Storage Condition

Store below 30 degree centigrade temperature. Protect from light and moisture. Keep out of the reach of children.

Innovators Monograph

You find simplified version here Colgit

*** Taking medicines without doctor's advice can cause long-term problems.