Coenzyme Q-10

Coenzyme Q-10 Uses, Dosage, Side Effects, Food Interaction and all others data.

Coenzyme Q10 is an essential cofactor in the mitochondrial electron transport chain, where it accepts electrons from complex I and II, an activity that is vital for the production of ATP.

Ubidecarenon has roles in many prysiological process including sulfide oxidation, regulation of mitochondrial permeability transition pore and translocation of protons and calcium ions accross biological membranes. Studies have shown its benefitial effect in treating cancer, statin myopathy, congestive heart failure and hypertension.

Trade Name Coenzyme Q-10
Generic Ubidecarenone
Ubidecarenone Other Names Coenzyme Q-10, Coenzyme Q10, Ubidecarenone
Type
Formula C59H90O4
Weight Average: 863.3435
Monoisotopic: 862.683911368
Protein binding

In the blood, ubidecarenone is split into the various lipoprotein particles including LDL and VLDL. The plasma concentration of ubidecarenone is highly dependent on the presence of plasma lipoproteins and about 95% of the administered form is found in the reduced form.

Groups Approved, Investigational, Nutraceutical
Therapeutic Class Oral nutritional preparations
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Coenzyme Q-10
Coenzyme Q-10

Uses

HMG CoA reductase inhibitors mediated decreased level of Coenzyme Q10 in blood, Drug induced Myopathy, Protects body against free radical damage with its antioxidant property, Adjuvant therapy in cardiovascular disease especially in angina and congestive heart failure, Immune system depression, Cognitive decline, Useful in the management of Periodontal Disease

Coenzyme Q-10 is also used to associated treatment for these conditions: Migraine

How Coenzyme Q-10 works

Coenzyme Q-10 is an essential cofactor in the mitochondrial electron transport chain. Its functions are the acceptance of electrons from the complex I and II and this activity is vital for the production of ATP. It acts as a mobile redox agent shuttling electrons and protons in the electron transport chain. Coenzyme Q-10 also presents antioxidant activity in mitochondria and cellular membranes, protecting against peroxidation of lipid membranes as well as inhibiting oxidation of LDL-cholesterol.

Dosage

Coenzyme Q-10 dosage

The recommended dose of Co-enzyme Q10 is:

For Co-enzyme Q10 deficiency:150 mg daily.

For mitochondrial disorders:150-160 mg, or 2 mg/kg/day.

For heart failure in adults:100 mg per day divided into 2 or 3 doses.

For recent myocardial infarction:120 mg daily in 2 divided doses.

For high blood pressure:120-200 mg per day divided into 2 doses.

For isolated systolic hypertension:60 mg twice daily.

For preventing migraine headache:100 mg three times daily.

For Parkinsons disease:300 mg, 600 mg, 1200 mg and 2400 mg per day in 3-4 divided doses.

For infertility in men:200-300 mg per day.

For muscular dystrophy:100 mg per day.

Dividing the total daily dose by taking smaller amounts two or three times a day instead of a large amount all at once can help to reduce side effects.

Side Effects

Coenzyme Q10 is well tolerated and having no significant side effects. Mild gastrointestinal symptoms such as nausea, diarrhea and epigastric distress have been reported.

Toxicity

There have not been reports of adverse events of diet supplementation with ubidecarenone. The normal side effects reported in humans are related to the gastrointestinal tract.

Precaution

Supplemental Coenzyme Q10 may improve beta-cell function and glycemic control in type II diabetics. Therefore, those diabetic patients who do use supplemental Coenzyme Q10 should determine by appropriate monitoring if they need to make any adjustments in their diabetic medications.

Interaction

Warfarin: Supplemental Coenzyme Q10 may decrease the effectiveness of Warfarin.

Statins: The statin drugs are known to decrease Coenzyme Q10 levels in humans.

Doxorubicin: Coenzyme Q10 may increase the cardiotoxicity of doxorubicin.

Antidiabetic medications: Coenzyme Q10 may improve glycemic control in some type II diabetics. If this were to occur, antidiabetic medications might need appropriate adjusting

Food Interaction

  • Take with or without food. Many different products contain ubidecarenone; refer to the product monograph for more specific instructions.

Volume of Distribution

Coenzyme Q-10 is distributed to the various tissues of the body and it is able to enter the brain. In preclinical studies with intravenous administration of ubidecarenone, it is reported a volume of distribution of 20.4 L/kg which reflects its ability to penetrate extensively into organs and tissues. AS a general rule, tissues with high-energy requirements or metabolic activity tend to presents higher amounts of ubidecarenone, these organs can be heart, kidney, liver and muscle.

Elimination Route

Coenzyme Q-10 is absorbed from the small intestine into the lymphatics and then it can enter the blood. The hydrophobicity and large molecular weight limit its absorption making it very poor and variable depending on the food intake and the number of lipids presented in the food. The absorption is lower in the presence of an empty stomach and greater in presence of high lipid food diet. The daily dosage of ubidecarenone presents the reach of maximal serum concentration by reaching a plateau after three weeks. The pharmacokinetic properties may vary between different brands but studies have reported an AUC of 11.51 mcg h/ml and a Cmax of 0.32 mcg/ml at a time of 7.9 h.

Half Life

The pharmacokinetic properties may vary between different brands but studies have reported a half-life of ubidecarenone of 21.7 h.

Clearance

In preclinical studies with intravenous administration of ubidecarenone, it is reported a total clearance of 1.18 ml h/kg which was indicative of a prolonged elimination.

Elimination Route

The main elimination route of ubidecarenone is through the bile. After its oral administration, over 60% of the dose is excreted in the feces in the form of unchanged ubidecarenone and a small fraction of the metabolites. In the urine, ubidecarenone is bound to saposin B protein and represents only 8.3% of the total administered dose.

Pregnancy & Breastfeeding use

Because of lack of information on long-term safety, pregnant women and nursing mothers should avoid Coenzyme Q10.

Contraindication

Patients with a known hypersensitivity to any component of this product

Storage Condition

Store in a cool & dry place, protect from light & moisture. Keep out of the reach of children.

Innovators Monograph

You find simplified version here Coenzyme Q-10

FAQ

What is Coenzyme Q-10 used for?

Coenzyme Q-10 is used to increase the cardiac input as well as for the prevention of several other diseases like Parkinson, fibromyalgia, migraine, periodontal disease and diabetes, based on preclinical studies.

What are the side effects of Coenzyme Q-10?

May common side effect of Coenzyme Q-10 include;

  • Stomach upset.
  • Decreased appetite.
  • Diarrhea.
  • Increased levels of liver enzymes in the blood.
  • Nausea.


Is Coenzyme Q-10 safe in pregnancy?

Coenzyme Q-10 has been used safely by pregnant women starting at 20 weeks gestation until term.

How much Coenzyme Q-10 should I take for fertility?

Fertility specialists recommend taking anywhere between 100mg and 300mg of CoQ10 daily.

Who should not take Coenzyme Q-10?

People with chronic diseases such as heart failure, kidney or liver problems, or diabetes should be wary of using this supplement. CoQ10 may lower blood sugar levels and blood pressure.

Is Coenzyme Q-10 safe to take daily?

While it's generally considered to be safe for healthy adults,Coenzyme Q-10 can be potentially harmful to people with certain conditions or those taking certain medications.

What are the benefits of Coenzyme Q-10?

Coenzyme Q-10 offers a wide range of health benefits, it supports heart health, the production of cellular energy, male fertility, healthy cholesterol and general health and wellbeing in ageing individuals.

Coenzyme Q-10 safe while breastfeeding?

The safety of use ofCoenzyme Q-10 during breast-feeding hasn't been established. Don't use Coenzyme Q-10 if you're pregnant or breast-feeding without your doctor's approval.

Can I drink alcohol with Coenzyme Q-10?

Mixing alcohol with certain medications can cause nausea and vomiting, headaches, drowsiness, fainting, or loss of coordination.Coenzyme Q-10 also can put you at risk for internal bleeding, heart problems, and difficulties in breathing.

Is Coenzyme Q-10 safe to take long term?

Coenzyme Q-10 is generally considered to be safe for healthy adults,it can be potentially harmful to people with certain conditions or those taking certain medications.

What happens if I miss a dose?

Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

*** Taking medicines without doctor's advice can cause long-term problems.
Share