Clove
Clove Uses, Dosage, Side Effects, Food Interaction and all others data.
Clove is a herbal medicine which main ingredient is clove oil. It contains a large amount of eugenol that is commonly used in the treatment of oral infections and inflammation of the mucous membranes of the mouth and throat. Clove is effective, safe and well tolerated for all age groups
Clove (Eugenia caryophyllata Thunb. [Myrtaceae]) essential oil (CEO) has been demonstrated to possess antimicrobial, antifungal, antiviral, antioxidant, anti-inflammatory, anti-histamine, and anticancer properties. However, few studies have focused on its topical use , .
Clove essential oil, used as an antiseptic in oral infections, inhibits gram-negative and gram-positive bacteria as well as yeast .
| Trade Name | Clove |
| Generic | Clove oil |
| Clove oil Other Names | Caryophylii floris aetheroleum, Caryophyllus aromaticus bud oil, Clove bud oil, Clove volatile oil, Ding xiang bud oil, Eugenia aromatica bud oil, Eugenia caryophyllata bud oil, Eugenia caryophyllus (clove) bud oil, Eugenia caryophyllus (clove) flower oil, Nelken oel, Syzygium aromaticum bud oil, Syzygium aromaticum oil |
| Type | |
| Groups | Approved, Nutraceutical |
| Therapeutic Class | Oral preparations |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
How Clove works
The chief constituent present in clove oil is the phenol "eugenol" which is present in amounts up to 85%. Clove acts as a germicide to Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa .
Clove is thought to inhibit prostaglandin synthesis, thereby reducing painful symptoms .
Eugenol, the main constituent of clove oil is purported to have anticancer action. In one study, eugenol-treated HL-60 cells showed features of apoptosis including DNA fragmentation and formation of DNA ladders in agarose gel electrophoresis. It was observed that eugenol transduced the apoptotic signal via reactive oxygen species (ROS) generation, inducing mitochondrial permeability transition (MPT), decreasing anti-apoptotic protein bcl-2 level, inducing cytochrome c release to the cytosol, and subsequent apoptotic cell death. When taken together, the study showed that ROS plays a critical role in eugenol-induced apoptosis in HL-60, and this is the first report on the mechanism of the anticancer effect of eugenol .
Dosage
Clove dosage
Adult: Should be taken 5 ml Clove with 10 ml-15 ml water and gurgle for 30 seconds of morning & bedtime daily.
Children: Should be taken 2.5 ml Clove with 10 ml water and gurgle for 30 seconds of morning & bedtime daily. Also undiluted clove oil is used in temporary relief of toothache due to dental cavity. Repeat administration after 20 minutes, then every 2 hours thereafter if necessary.
Side Effects
In concentrated form oil of clove may be irritating to mucosal tissues.
Toxicity
Acute oral toxicity (LD50): 2650 mg/kg [Rat] .
Clove is considered safe in small quantities (< 1,500 ppm) as a food additive . the lethal oral dose is 3.75 g per kg body weight in humans .
Contact with skin or soft tissue may cause transient irritation, contact dermatitis, inflammation of the lips, and inflammation or ulceration of the mouth. The eugenol present in clove oil may act as an irritant to skin and mucous membranes; it may also cause hypersensitivity and is reported to inhibit prostaglandin synthesis. Patients may become sensitive to clove oil .
After oral administration of 5-10 ml of clove oil in children below 2 years of age, life-threatening conditions were observed. Adverse effects included coma, acidosis, a generalized seizure, disordered blood clotting, and acute liver damage .
Overdose may lead to CNS depression, urinary abnormalities, anion-gap acidosis, deterioration of liver function, coma, seizure and low blood glucose levels. Treatment should be supportive and symptomatic; there have been reports in the literature that N-acetylcysteine has been successfully used as an antidote .
There are no epidemiological studies of potential adverse human health effects related to exposure to clove leave oil or eugenol from any human exposure scenarios. Nor are there any studies of agricultural use, either in workers or those with bystander exposure or other applications. There are no occupational exposure standards for clove leaf oil or eugenol including OSHA PEL (Permissible Exposure Limit) or AGIHA TLVs (Threshold Limit Value) in air .
Food Interaction
No interactions found.Elimination Route
Clove is rapidly absorbed through the skin and is used in patented systems for dermal drug delivery to enhance drug uptake from skin patch delivery systems .
Half Life
In a pharmacokinetic study, average half-life values of eugenol in plasma and blood were long (14.0 and 18.3 h, respectively), suggesting a potential accumulation of the drug following repeated administrations .
Elimination Route
In a pharmacokinetic study, the metabolism of eugenol (the primary constituent of clove oil) was investigated in healthy male and female volunteers. It was quickly absorbed and metabolized after oral administration and was almost completely excreted in the urine within 24 hours of ingestion .
Pregnancy & Breastfeeding use
There are no known problems with the use of Clove during pregnancy and lactation.
Storage Condition
Store below 30°C. temperature & dry place, protected from light. Keep all medicines out of reach of children.
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