Cleen See

Cleen See Uses, Dosage, Side Effects, Food Interaction and all others data.

Cleen See is a lincosamide antibiotic used in the treatment of infections caused by susceptible microorganisms. Cleen See is a semisynthetic antibiotic derived from lincomycin. It has antiacne and antibacterial activity. It binds with the 50s subunit of the bacterial ribosome and inhibits the early stage of protein synthesis. It is highly potent against gram positive and anaerobic bacteria.

Microbiology: Aerobic gram-positive cocci, including: Staphylococcus aureus, Staphylococcus epidermidis (penicillinase and non-penicillinase producing strains), Streptococci, Pneumococci. Anaerobic gram-negative bacilli, including: Bacteroides species, Fusobacterium species. Anaerobic gram-positive non-spore forming bacilli, including: Propionibacterium species, Eubacterium species, Actinomyces species. Anaerobic and microaerophilic gram-positive cocci, including: Peptococcus species, Peptostreptococcus species, Microaerophilic streptococci, C. perfringes

Cleen See exerts its bacteriostatic effect via inhibition of microbial protein synthesis. Cleen See has a relatively short Tmax and half-life necessitating administration every six hours to ensure adequate antibiotic concentrations.

Clostridium difficile associated diarrhea (CDAD) has been observed in patients using clindamycin, ranging in severity from mild diarrhea to fatal colitis and occasionally occurring over two months following cessation of antibiotic therapy. Overgrowth of C. difficile resulting from antibiotic use, along with its production of A and B toxins, contributes to morbidity and mortality in these patients. Because of the associated risks, clindamycin should be reserved for serious infections for which the use of less toxic antimicrobial agents are inappropriate.

Cleen See is active against a number of gram-positive aerobic bacteria, as well as both gram-positive and gram-negative anaerobes. Resistance to clindamycin may develop, and is generally the result of base modification within the 23S ribosomal RNA. Cross-resistance between clindamycin and lincomycin is complete, and may also occur between clindamycin and macrolide antibiotics (e.g. erythromycin) due to similarities in their binding sites.

Trade Name Cleen See
Availability Prescription only
Generic Clindamycin
Clindamycin Other Names 7-CDL, Clindamicina, Clindamycin, Clindamycine, Clindamycinum
Related Drugs amoxicillin, prednisone, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, ceftriaxone, dexamethasone, levofloxacin
Type Gel
Formula C18H33ClN2O5S
Weight Average: 424.98
Monoisotopic: 424.179871
Protein binding

Clindamycin protein binding is concentration-dependent and ranges from 60-94%. It is bound primarily to alpha-1-acid glycoprotein in the serum.

Groups Approved, Vet approved
Therapeutic Class Miscellaneous Antibiotics
Manufacturer Intellect Lifescience
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Cleen See
Cleen See


Clindacin lotion is used for the treatment of acne vulgaris.

Other uses of topical Cleen See lotion are:

• Skin infections such as erythrasma caused by Corynebacterium minutissimum; rosacea, periorificial dermatitis, folliculitis, stasis, chronic lymphaedema and familial pemphigus.

• Dermal ulcers.

Cleen See is also used to associated treatment for these conditions: Abscess, Intra-Abdominal caused by Anaerobic Bacterial Infection, Acne Vulgaris, Babesiosis, Bacterial Endocarditis, Bacterial Vaginosis (BV), Bloodstream Infections caused by Anaerobic Bacterial Infection, Bone and Joint Infections caused by susceptible Staphylococcus, Empyema caused by Anaerobic Bacterial Infection, Endometritis caused by Anaerobic Bacterial Infection, Lung Abscess caused by Anaerobic Bacterial Infection, Malaria caused by Plasmodium falciparum, Mixed Vaginal Infections, Pelvic cellulitis caused by Anaerobic Bacterial Infection, Peritonitis caused by Anaerobic Bacterial Infection, Pneumocystis Jirovecii Pneumonia, Pneumonitis caused by Anaerobic Bacterial Infection, Respiratory Tract Infections (RTI) caused by susceptible Staphylococcus, Respiratory Tract Infections (RTI) caused by susceptible pneumococci, Respiratory Tract Infections (RTI) caused by susceptible streptococci, Skin Structures and Soft Tissue Infections caused by Anaerobic Bacterial Infection, Skin Structures and Soft Tissue Infections caused by susceptible Staphylococcus, Skin Structures and Soft Tissue Infections caused by susceptible streptococci, Toxoplasmosis, Tubo-ovarian abscess caused by Anaerobic Bacterial Infection, Vaginal Candidiasis, Vaginal Mycosis, Chronic Bone and Joint Infections caused by Susceptible infections, Moderate Acne vulgaris, Post-surgical vaginal cuff infection caused by Anaerobic Bacterial Infection, Viridans group streptococci

How Cleen See works

Cleen See inhibits bacterial protein synthesis by binding to 23S RNA of the 50S subunit of the bacterial ribosome. It impedes both the assembly of the ribosome and the translation process. The molecular mechanism through which this occurs is thought to be due to clindamycin's three-dimensional structure, which closely resembles the 3'-ends of L-Pro-Met-tRNA and deacylated-tRNA during the peptide elongation cycle - in acting as a structural analog of these tRNA molecules, clindamycin impairs peptide chain initiation and may stimulate dissociation of peptidyl-tRNA from bacterial ribosomes.

The mechanism through which topical clindamycin treats acne vulgaris is unclear, but may be related to its activity against Propionibacterium acnes, a bacteria that has been associated with acne.


Cleen See dosage

At first wash the face or affected area gently with warm water or soap.

Clindacin lotion: When the skin is completely dried (about 30 minutes later) apply a thin film of Clindacin lotion to the entire affected area twice daily. Applied area should not be washed within 3 hours. Noticeable improvement is usually seen after about 6 weeks . However, 8 to 12 weeks of treatment may be required for maximum benefit. Eye, lip or nose contact should be avoided while applying Clindacin lotion.

Cleen See Lotion 1%: Clean the face or affected area gently with warm water or soap as recommended by the physician. After the skin is dried, apply a thin film of lotion to the affected areas twice daily, in the morning and in the evening.

Do not wash within three hours after using lotion. The treatment period is usually 6 weeks or as advised by the physician.

However, 8 to 12 weeks of treatment may be required for maximum benefit.

Cleen See 2% Vaginal preparation: One applicator full (approximately 5 gm) intravaginally at bedtime for 7 consecutive days. In patients in whom a shorter treatment course is desirable, a 3 day regimen has been shown to be effective.

Side Effects

Side effects are usually rare. Possible side-effects may includes skin rash, itching, oily skin, dryness, erythema, burning, change in skin color, diarrhea, colitis, GI disturbance etc.


The oral LD50 in mice and rats is 2540 mg/kg and 2190 mg/kg, respectively.

While no cases of overdose have been reported, symptoms are expected to be consistent with the adverse effect profile of clindamycin and may therefore include abdominal pain, nausea, vomiting, and diarrhea. During clinical trials, one 3-year-old child was given a dose of 100 mg/kg daily for 5 days and showed only mild abdominal pain and diarrhea. Activated charcoal may be of value to remove unabsorbed drug, but hemodialysis and peritoneal dialysis are ineffective. General supportive measures are recommended in cases of clindamycin overdose.


Clindacin lotion is not for oral, ophthalmic, or Intravaginal use.

Avoid exposure to sunlight and sunlamps. Wear sunscreen daily.


Cleen See enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents. Antagonism has been demonstrated between clindamycin and erythromycin in vitro. Because of possible clinical significance, these two drugs should not be administered concurrently.

Food Interaction

  • Take with a full glass of water. Cleen See may cause esophageal irritation if the dosage form becomes lodged.
  • Take with or without food. Food does not appreciably alter the absorption of clindamycin.

Volume of Distribution

Cleen See is widely distributed in the body, including into bone, but does not distribute into cerebrospinal fluid. The volume of distribution has been variably estimated between 43-74 L.

Elimination Route

Oral bioavailability is nearly complete, at approximately 90%, and peak serum concentrations (Cmax) of, on average, 2.50 µg/mL are reached at 0.75 hours (Tmax). The AUC following an orally administered dose of 300mg was found to be approximately 11 µg•hr/mL. Systemic exposure from the administration of vaginal suppository formulations is 40-fold to 50-fold lower than that observed following parenteral administration and the Cmax observed following administration of vaginal cream formulations was 0.1% of that observed following parenteral administration.

Half Life

The elimination half-life of clindamycin is about 3 hours in adults and 2.5 hours in children. Half-life is increased to approximately 4 hours in the elderly.


The plasma clearance of clindamycin is estimated to be 12.3-17.4 L/h, and is reduced in patients with cirrhosis and altered in those with anemia.

Elimination Route

Approximately 10% of clindamycin bioactivity is excreted in the urine and 3.6% in the feces, with the remainder excreted as inactive metabolites.

Pregnancy & Breastfeeding use

Pregnancy: There is no adequate data for safe use in pregnancy. Animal studies showed no adverse effects on the fetus.

Lactation: It is not known that whether Cleen See is excreted through breast milk following topical administration. However, Clindacin lotion can be used during lactation with caution.


Cleen See is contraindicated in patients previously found to be sensitive to clindamycin or any of the ingredients of this medicine.

Acute Overdose

Overdosage with orally administered clindamycin has been rare. Adverse reactions similar to those seen with normal doses can be expected, however, unexpected reactions could occur. Haemodialysis and peritoneal dialysis are not effective in removing clindamycin from the serum. Overdosage should be treated with simple gastric lavage. No specific antidote is known.

Interaction with other Medicine

Cleen See enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents. Antagonism has been demonstrated between clindamycin and erythromycin in vitro. Because of possible clinical significance, these two drugs should not be administered concurrently.

Storage Condition

Store between 20-25°C. Do not refrigerate or freeze.

Innovators Monograph

You find simplified version here Cleen See

Cleen See contains Clindamycin see full prescribing information from innovator Cleen See Monograph, Cleen See MSDS, Cleen See FDA label


What is Cleen See used for?

Cleen See is used to treat a wide variety of bacterial infections. It is an antibiotic used for treatment of a number of bacterial infections, including bone or joint infections, pelvic inflammatory disease, strep throat, pneumonia, middle ear infections, and endocarditis. It can also be used to treat acne, and some cases of methicillin-resistant Staphylococcus aureus.

How does Cleen See work?

Cleen See works by inhibiting bacterial protein synthesis, which inhibits bacterial growth. It works by slowing or stopping the growth of bacteria.

How safe is Cleen See?

Cleen See is an effective antibiotic for a variety of serious infections. People can also use Cleen See for treating acne. However, there are many possible side effects of Cleen See. For this reason, doctors should weigh the benefits and risks before prescribing this antibiotic.

What are the common side effects of Cleen See?

Common side effects of Cleen See are include:

  • nausea
  • vomiting
  • unpleasant or metallic taste in the mouth
  • joint pain
  • pain when swallowing
  • heartburn
  • white patches in the mouth
  • thick, white vaginal discharge
  • burning, itching, and swelling of the vagina

Is Cleen See safe during pregnancy?

Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.Use during the first trimester is not recommended unless clearly needed.

Is Cleen See safe during pregnancy?

If oral or intravenous Cleen See is required by a nursing mother, it is not a reason to discontinue breastfeeding, but an alternate drug may be preferred.

Can I drink alcohol with Cleen See?

It is generally safe to drink alcohol while taking Cleen See.

Can I drive after taking Cleen See?

Cleen See may cause some people to become dizzy. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy.

What time should I take Cleen See?

Take Cleen See by mouth with or without food, usually 4 times a day (every 6 hours), or as directed by your doctor.

Do I need to take Cleen See with food?

Cleen See capsules and oral solution may be taken with or without food.

How long does Cleen See take to work?

Once you start taking Cleen See, you'll likely notice an improvement in your symptoms after a day or two. If your symptoms aren't improving at all or seem to be getting worse after taking Cleen See for a few days, follow up with your healthcare provider.

How long does Cleen See stay in my system?

After oral administration of Cleen See hydrochloride, the average elimination half-life is increased to approximately 4.0 hours in the elderly compared to 3.2 hours in younger adults.

How many times can I take Cleen See?

Take Cleen See exactly as your doctor tells you to. The usual dose for adults is 150-300 mg four times daily, but the dose may be less than this if it is prescribed for a child.

Can I take Cleen See for a long time?

However, to help keep your acne under control, keep using this medicine for the full time of treatment, even if your symptoms begin to clear up after a few days. You may have to continue using this medicine every day for months or even longer in some cases.

Can I just stop taking Cleen See?

Do not stop taking Cleen See or skip doses if you start to feel better. Doing so could cause your infection to last longer.

Is Cleen See safe for kidneys?

Cleen See is eliminated by the kidney to a limited extent. Therapy with Cleen See should be administered cautiously in patients with severely impaired renal function.

What happen if I stop taking Cleen See?

If you stop taking Cleen See too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

Can Cleen See affect my heart?

Serious heart problems could develop later if your infection is not cleared up completely. Also, if you stop taking this medicine too soon, your symptoms may return.

Who should not take Cleen See?

If you have severe liver disease,blood in the bowel movement, severe renal impairment, a type of allergy you should not take Cleen See.

Can I take too much Cleen See?

It is important that you do not use this medicine more often than your doctor ordered. It may cause your skin to become too dry or irritated.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

*** Taking medicines without doctor's advice can cause long-term problems.