Claripel Plus
Claripel Plus Uses, Dosage, Side Effects, Food Interaction and all others data.
Claripel Plus is a topical depigmentating agent that produces a reversible depigmentation of the skin by inhibiting enzymatic oxidation of tyrosine to 3,4-dihydroxyphenylalanine and suppressing melanocyte metabolic processes.
| Trade Name | Claripel Plus |
| Generic | Hydroquinone |
| Hydroquinone Other Names | 1,4-benzenediol, Hydroquinone, Quinol |
| Type | Cream |
| Formula | C6H6O2 |
| Weight | Average: 110.1106 Monoisotopic: 110.036779436 |
| Groups | Approved, Investigational |
| Therapeutic Class | Hydroquinone Preparations |
| Manufacturer | Glaxosmithkline |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Claripel Plus is used -
- For the gradual bleaching of hyperpigmented skin conditions such as chloasma, melasma, freckles, senile lentigines and other unwanted areas of melanin hyperpigmentation.
- To reduce hyperpigmentation caused by photosensitization associated with inflammation or with the use of certain cosmetics.
Claripel Plus is also used to associated treatment for these conditions: Acne Vulgaris, Melasma, Skin hyperpigmentation, Moderate Melasma, Severe Melasma
How Claripel Plus works
Claripel Plus reduces melanin pigment production through inhibition of the tyrosinase enzyme, which is involved in the initial step of the melanin pigment biosynthesis pathway. Claripel Plus takes several months to take effect.
Dosage
Claripel Plus dosage
Apply a thin film of Claripel Plus Cream to the effected area once daily, at least 30 minutes before bedtime. Gently wash the face and neck with a mild cleanser. Rinse and pat the skin dry. Apply Claripel Plus Cream to the hyperpigmented areas of melasma including about ½ inch of normal appearing skin surrounding eachlesion. Rub lightly and uniformly into the skin.
Therapy should be discontinued when control is achieved. During the day, use asunscreenof SPF 30, and wear protective clothing. Avoid sunlight exposure. Patients may use moisturizers and/or cosmetics during the day. Claripel Plus Cream is for topical use only. It is not for oral,ophthalmic, or intravaginal use.
Side Effects
No systemic adverse reactions have been reported. Occasional hypersensitivity (localized contact dermatitis) may occur in which case the medication should be discontinued.
Precaution
Claripel Plus is a skin bleaching agent which may produce unwanted cosmetic effects if not used as directed. The physician should be familiar with the contents of this insert before prescribing or dispensing this medication.
Test for skin sensitivity before using by applying a small amount to an unbroken patch of skin to check in 24 hours. Minor redness is not a contraindication, but where there is itching or vesicle formation or excessive inflammatory response, further treatment is not advised. If no bleaching or lightening effect is noted after 2 months of treatment, the medication should be discontinued.
Contact with the eyes and lips should be avoided. Claripel Plus should not be applied to cut or abraded skin.
Food Interaction
No interactions found.Pregnancy & Breastfeeding use
Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Lactation: It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when topical hydroquinone is used by a nursing mother.
Contraindication
Claripel Plus is contraindicated to patients with prior history of hypersensitivity or allergic reaction to hydroquinone or other ingredients in the preparation.
Acute Overdose
There have been no systemic reactions from the use of topical hydroquinone. Some patients may experience a transient reddening of skin and mild burning sensation which does not preclude treatment.
Storage Condition
Store between 20-25° C. Protect from light.
Innovators Monograph
You find simplified version here Claripel Plus
Claripel Plus contains Hydroquinone see full prescribing information from innovator Claripel Plus Monograph, Claripel Plus MSDS, Claripel Plus FDA label
FAQ
What is Claripel Plus used for?
Claripel Plus is used to lighten the dark patches of skin (also called hyperpigmentation, melasma, "liver spots," "age spots," freckles) caused by pregnancy, birth control pills, hormone medicine, or injury to the skin. Claripel Plus also known as benzene-1,4-diol or quinol, is an aromatic organic compound that is a type of phenol, a derivative of benzene, having the chemical formula C₆H₄(OH)₂. It has two hydroxyl groups bonded to a benzene ring in a para position.
How safe is Claripel Plus?
Claripel Plus is deemed safe in the United States. There isn't any clinical evidence currently to suggest that Claripel Plus is harmful to humans. However, minor side effects are still possible. It may cause a temporary uptick in redness or dryness at first, especially if you have sensitive skin.
How does Claripel Plus work?
Claripel Plus bleaches your skin by decreasing the number of melanocytes present.
What are the common side effects of Claripel Plus?
Common side effects of Claripel Plus include:
- Mild skin irritation and sensitization (burning, stinging)
- Dermatitis.
- Dryness.
- Redness.
- Inflammatory reaction.
Is Claripel Plus safe during pregnancy?
Whitening and brightening solutions with Claripel Plus are safe to use during pregnancy and won't harm the foetus.
Is Claripel Plus safe during breastfeeding?
Claripel Plus is not contraindicated during breastfeeding and if Claripel Plus is required by the mother, it is not a reason to discontinue breastfeeding. However, some experts feel that long-term use of Claripel Plus is difficult to justify in a nursing mother.
Can Claripel Plus make me blind?
Inhaling Claripel Plus can irritate the nose and throat.
Is Claripel Plus hazardous?
Claripel Plus is also a skin irritant in humans. Chronic (long-term) occupational exposure to Claripel Plus dust can result in eye irritation, corneal effects, and impaired vision.
Can I leave Claripel Plus on overnight?
Apply Claripel Plus cream once daily to clean, dry skin, preferably at bedtime, and leave on overnight.
Can I use Claripel Plus everyday?
Claripel Plus a tyrosinase inhibitor, in a 4% cream can be used safely twice daily for up to 6 months to treat post-inflammatory hyperpigmentation. The efficacy of this treatment can be enhanced by using a retinoid nightly and a mid-potent steroid, which is applied twice daily for 2 weeks, then at weekends only.
How fast does Claripel Plus work?
It takes about four weeks on average for the ingredient to take effect.
How long should I use Claripel Plus?
You can use the product for up to four months, and then begin to taper off use.
Can Claripel Plus be used in the morning?
Apply Claripel Plus in the evening after Retin-A and in the morning for 2 to 6 weeks prior to the procedure.
How often can I use Claripel Plus?
Claripel Plus a tyrosinase inhibitor, in a 4% cream can be used safely twice daily for up to 6 months to treat post-inflammatory hyperpigmentation.
How long does Claripel Plus take to work?
Claripel Plus takes about four weeks on average for the ingredient to take effect.
Can I take Claripel Plus for long time?
You shouldn't use products with this ingredient for more than five months at a time.
When should I stop taking Claripel Plus?
Claripel Plus stop application after five months. If your skin lightens, stop using Claripel Plus regularly and only use it if the dark spots reappear. Wait two or three months to use it in the same areas.
Who should not take Claripel Plus?
Do not use Claripel Plus topical on open wounds or on sunburned, windburned, dry, chapped, or irritated skin. Call your doctor if your symptoms do not improve after 2 months, or if your condition gets worse.
What happens if I miss a dose?
Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.
What happens if I overdose of Claripel Plus?
An overdose of Claripel Plus topical is not expected to be dangerous. Seek emergency medical attention if anyone has accidentally swallowed the medication.
What happen If I stop taking Claripel Plus?
Prolonged regular use of Claripel Plus may lead to exogenous ochronosis, which can cause blue-black pigmentation and papules, red bumps on the skin.
Is Claripel Plus hard on my heart?
Claripel Plus can cause dangerous effects on your heart, especially if you also use certain other medicines. Seek emergency medical attention if you have fast or pounding heartbeats and sudden dizziness
Can Claripel Plus affect my kidneys?
Claripel Plus produce significant histological alterations that might affect the liver and kidney.
Can Claripel Plus affects my liver?
Claripel Plus can remove the top layer of skin, increasing the risk of skin cancer and cause fatal liver and kidney damage.
