Chlormethylenecycline
Chlormethylenecycline Uses, Dosage, Side Effects, Food Interaction and all others data.
Chlormethylenecycline is a tetracycline used to treat bacterial infections.
Chlormethylenecycline is a tetracycline antibiotic that is commonly prescribed by medical doctors for infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia. Chlormethylenecycline is also used commonly as a prophylactic treatment for infection by Bacillus anthracis (anthrax). It is also effective against Yersinia pestis and malaria and is also prescribed for the treatment of Lyme disease. Chlormethylenecycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Cells become resistant to Chlormethylenecycline by at least two mechanisms: efflux and ribosomal protection. In efflux, a resistance gene encodes a membrane protein that actively pumps Chlormethylenecycline out of the cell. This is the mechanism of action of the tetracycline resistance gene on the artificial plasmid pBR322. In ribosomal protection, a resistance gene encodes a protein which binds to the ribosome and prevents Chlormethylenecycline from acting on the ribosome.
| Trade Name | Chlormethylenecycline |
| Generic | Clomocycline |
| Clomocycline Other Names | Chlormethylenecycline, Clomociclina, Clomocyclina, Clomocycline, Clomocyclinum |
| Type | |
| Formula | C23H25ClN2O9 |
| Weight | Average: 508.906 Monoisotopic: 508.124858115 |
| Groups | Experimental |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment and management of Brucellosis, mycoplasma infection, acne vulgaris, chlamydial infection;Chronic bronchitis
How Chlormethylenecycline works
Chlormethylenecycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Chlormethylenecycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane.
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