Cardogrel

Cardogrel Tablet

(Cardogrel) is an inhibitor of platelet aggregation. Lopirel (Cardogrel) selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation.

Uses

(Cardogrel) is used for the reduction of atherosclerotic events (myocardial infarction, ischaemic stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease.

Cardogrel is also used to associated treatment for these conditions: Acute Coronary Syndrome (ACS), Acute Myocardial Infarction (AMI), Cardiovascular Events, Atherothrombotic events

Cardogrel

Trade Name Cardogrel
Generic Clopidogrel
Clopidogrel Other Names Clopidogrel, Clopidogrelum
Weight 75mg
Type Tablet
Formula C16H16ClNO2S
Weight Average: 321.822
Monoisotopic: 321.059027158
Protein binding

Both the active and inactive metabolites of clopidogrel are 98% protein bound in plasma. Studies in cows show clopidogrel 71-85.5% bound to serum albumin.

Therapeutic Class Anti-platelet drugs
Manufacturer Pharmasia Ltd
Available Country Bangladesh
Last Updated: June 23, 2021 at 11:19 am

Structure

Cardogrel
Clopidogrel Structure

Dosage

Cardogrel dosage

The recommended dose of Lopirel (Cardogrel) is 75 mg once daily with or without food.

Side Effects

Generally Cardogrel is well tolerated. However, a few common side effects i.e. Influenza-like symptoms, headache, upper respiratory tract infection, dizziness, muscle and back pain, and rash may occur.

Precaution

As with other anti-platelet agents, Cardogrel should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery, or other pathological conditions. Cardogrel should be discontinued 7 days prior to surgery. Cardogrel should be used with caution in hepatically impaired patients who may have bleeding diatheses.

Interaction

Concomitant use of Heparin, Warfarin and NSAIDs with Cardogrel should be undertaken with caution. Cardogrel potentiate the effect of Aspirin on collagen-induced platelet aggregation. The safety of chronic concomitant administration of Aspirin and Cardogrel has not been established.

Food Interaction

  • Take with or without food.

Volume of Distribution

The apparent volume of distribution of clopidogrel is 39,240±33,520L.

Half Life

That half life of clopidogrel is approximately 6 hours following a 75mg oral dose while the half life of the active metabolite is approximately 30 minutes.

Clearance

The clearance of a 75mg oral dose was 18,960±15,890L/h and for a 300mg oral dose was 16,980±10,410L/h.

Pregnancy & Breastfeeding use

Pregnancy: There are no adequate and well-controlled studies of Cardogrel in pregnant women. However, Cardogrel should be used during pregnancy only if clearly needed.

Lactation: Cardogrel is not recommended for use while breast-feeding. It is not known for sure whether Cardogrel is excreted in breast milk, although it is suspected that it is.

Contraindication

Cardogrel is contraindicated in patients with a hypersensitivity to the drug substance or any component of the product, and those with active pathological bleeding such as peptic ulcer or intracranial hemorrhage.

Special Warning

Use in children: Safety and effectiveness of Cardogrel in pediatric population have not been established.

Acute Overdose

In the event of over dosage no adverse effects were reported and no therapy was substituted.

Symptoms: Prolonged bleeding time and subsequent bleeding complications.

Management: May restore clotting ability with platelet transfusion.

Storage Condition

Store at 25° C.

Innovators Monograph

Cardogrel contains Clopidogrel see full prescribing information from innovator Monograph