Carbinoxamine

Carbinoxamine Uses, Dosage, Side Effects, Food Interaction and all others data.

Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the counter cough and cold medicine is being modified to state "do not use" in children under 4 years of age in order to prevent and reduce misuse, as many unapproved carbinoxamine-containing preparations contained inappropriate labeling, which promoted unapproved uses (including management of congestion, cough, the common cold, and the use in children under 2 years of age), which can potentially cause serious health risks.

Carbinoxamine is a first generation antihistamine of the ethanolamine class. Ethanolamine antihistamines have significant antimuscarinic activity and produce marked sedation in most patients. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease. Rather than preventing the release of histamine, as do cromolyn and nedocromil, carbinoxamine competes with free histamine for binding at HA-receptor sites. Carbinoxamine competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Ethanolamine derivatives have greater anticholinergic activity than do other antihistamines, which probably accounts for the antidyskinetic action of carbinoxamine.

Trade Name Carbinoxamine
Availability Prescription only
Generic Carbinoxamine
Carbinoxamine Other Names Carbinoxamin, Carbinoxamina, Carbinoxamine, Carbinoxamine base, Carbinoxaminum, Paracarbinoxamine
Related Drugs prednisone, hydroxyzine, cetirizine, cetirizine ophthalmic, loratadine, fluticasone nasal, dexamethasone ophthalmic, promethazine, diphenhydramine, triamcinolone
Weight 4mg/5ml, 4mg/5ml, 4mg, 6mg
Type Oral liquid, oral suspension, extended release, oral tablet
Formula C16H19ClN2O
Weight Average: 290.788
Monoisotopic: 290.118590947
Groups Approved
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Carbinoxamine
Carbinoxamine

Uses

Carbinoxamine is a first generation antihistamine used to treat allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, allergic reactions, and mild allergic reactions.

For symptomatic relief of seasonal and perennial allergic rhinitis and vasomotor rhinitis, as well as allergic conjunctivitis caused by foods and inhaled allergens. Also for the relief of allergic reactions to blood or plasma, and the symptomatic management of mild, uncomplicated allergic skin manifestations of urticaria and angioedema.

Carbinoxamine is also used to associated treatment for these conditions: Allergic Reaction, Allergic Rhinitis (AR), Anaphylaxis, Angioedema, Seasonal Allergic Conjunctivitis, Urticaria, Vasomotor Rhinitis, Dermatographism

How Carbinoxamine works

Carbinoxamine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Carbinoxamine's anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown.

Food Interaction

  • Avoid alcohol. Ingesting alcohol may increase drowsiness caused by carbinoxamine.
  • Take on an empty stomach.

[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.

Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.

Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Half Life

10 to 20 hours

Innovators Monograph

You find simplified version here Carbinoxamine

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https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:3398
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http://www.genome.jp/dbget-bin/www_bget?cpd:C06871
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2564
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506787
https://www.chemspider.com/Chemical-Structure.2466.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81464
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=20220
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=3398
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL864
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP001069
http://www.pharmgkb.org/drug/PA164746898
http://www.rxlist.com/cgi/generic3/rondecsyr.htm
https://www.drugs.com/cdi/carbinoxamine-maleate.html
https://en.wikipedia.org/wiki/Carbinoxamine
*** Taking medicines without doctor's advice can cause long-term problems.
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