Canesten

Canesten Uses, Dosage, Side Effects, Food Interaction and all others data.

Canesten is a broad spectrum antifungal. It also exhibits activity against Trichomonus, Staphylococci, Streptococci and Bacteroides. Canesten kills fungi and yeasts by interfering with their cell membranes. It works by stopping the production of ergosterol, which is an essential component of fungal cell membranes resulting in increased membrane permeability and leakage of essential constituents of the fungal cells. Canesten acts reliably on dermatophytes, yeasts and other fungi; it is also effective against Trichomonas vaginalis and Gram-positive microorganisms (streptococci/ staphylococci) and Gram-negative microorganisms (bacteroides/ Haemophilus vaginalis).

Canesten is a broad-spectrum antifungal agent that inhibits the growth of pathogenic yeasts by changing the permeability of cell membranes. The action of clotrimazole is fungistatic at concentrations of drug up to 20 mcg/mL and may be fungicidal in vitro against Candida albicans and other species of the genus Candida at higher concentrations . Unfortunately, resistance to clotrimazole, which was rare in the past, is now common in various patient populations .

Canesten is generally considered to be a fungistatic, and not a fungicidal drug, although this contrast is not absolute, as clotrimazole shows fungicidal properties at higher concentrations .

Trade Name Canesten
Availability Prescription only
Generic Clotrimazole
Clotrimazole Other Names Clotrimazol, Clotrimazole, Clotrimazolum
Related Drugs fluconazole, nystatin, Diflucan, itraconazole, miconazole
Weight 1%, , 1%.
Type Lotion, Tablet, Ointment, Cream, Topical
Formula C22H17ClN2
Weight Average: 344.837
Monoisotopic: 344.108026261
Protein binding

98%

Groups Approved, Vet approved
Therapeutic Class Drugs for subcutaneous and systemic mycoses, Topical Antifungal preparations
Manufacturer Piramal Pharma Limited, Square Pharmaceuticals Ltd, Bayer Plc, Bayer Indonesia
Available Country India, Bangladesh, United Kingdom, Canada, United States, Netherlands, Portugal, Switzerland, Indonesia,
Last Updated: September 19, 2023 at 7:00 am
Canesten
Canesten

Uses

The confirmed indication for Canesten include:

  • All dermatomycoses due to dermatophytes (e.g. Trichophyton species).
  • All dermatomycoses due to yeasts (Candida species).
  • Dermatomycoses due to moulds and other fungi.
  • Skin diseases showing superinfections with these fungi.

To the dermatomycoses listed under 1-4 belong for example, interdigital myocoses (e.g. athlete’s foot), paronychias (associated with nail mycoses), myocoses in skin folds, Candida vulvitis, Candida balanitis, Pityriasis versicolor, erythrasma.

Canesten rectal preparation is used for vaginal itching, burning and discharge associated with recurrent vaginal yeast infections (Vaginal candidiasis) and also in viginitis due to Candida species as well as Mycotic infections complicated by other microorganisms sensitive to the drug.

Canesten Sterile Eye Ointment is used for the treatment of fungal keratitis due to filamentous fungi and Candida species.

Canesten Ear Drop is used for the treatment of fungal infections of the ear.

Canesten is also used to associated treatment for these conditions: Balanitis candida, Candidiasis, Dermatitis, Dermatomycoses, Ear infection fungal, Erythrasma, Fungal Vaginal Infections, Fungal skin infection, Genital candidiasis, Inflammation, Mixed Vaginal Infections, Oropharyngeal Candidiasis, Pityriasis versicolor, Pyoderma, Ringworm, Skin Infections, Skin candida, Tinea Corporis, Tinea Cruris, Tinea Pedis, Tinea inguinalis, Trichophytosis, Vaginal Candidiasis, Vaginal Mycosis, Vulvitis, Cutaneous candidiasis, Infection mycotic, Susceptible Bacterial Infections, Symptomatic Tinea Corporis caused by Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum, Symptomatic Tinea Cruris caused by Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum, Symptomatic Tinea Pedis caused by Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum, Tinea versicolor caused by Malassezia infection

How Canesten works

Canesten acts primarily by damaging the permeability barrier in the cell membrane of fungi. Canesten causes inhibition of ergosterol biosynthesis, an essential constituent of fungal cell membranes. If ergosterol synthesis is either completely or partially inhibited, the cell is no longer able to construct an intact and functional cell membrane ,. Because ergosterol directly promotes the growth of fungal cells in a hormone‐like fashion, rapid onset of the above events leads to dose-dependent inhibition of fungal growth .

Though decreased ergosterol, due to the inhibition of lanosterol 14-demethylase (also known as CYP51) is accepted to be primarily responsible for the antimycotic properties of clotrimazole, this drug also shows other pharmacological effects. These include the inhibition of sarcoplasmic reticulum Ca2+‐ATPase, depletion of intracellular calcium, and blocking of calcium‐dependent potassium channels and voltage‐dependent calcium channels . The action of clotrimazole on these targets accounts for other effects of this drug that are separate from its antimycotic activities .

Dosage

Canesten dosage

Topical

Wash skin with soap and water and dry thoroughly. Apply a thin layer of the cream or solution 2-3 times daily and gently massage over affected area as directed by the doctor. For Athlete’s foot, pay special attention to the spaces between the toes. Best results in Athlete's foot and ringworm are usually obtained with 4 weeks use of this product. The cream should be applied two or three times daily for one month or for at least two weeks after the disappearance of all signs of infection. If satisfactory results have not occurred within these times consultation with doctor is essential. For best results, follow directions and continue treatment for length of time indicated. The duration of treatment varies; it depends among other factors on the extent and localization of the disease.

Recommended duration of treatment :

  • Dermatomycoses: 3-4 weeks
  • Candida vulvitis and candida balanitis: 1-2 weeks
  • Erythrasma and pityriasis versicolor (approx.): 3 weeks
  • In fungal infection of the feet, to prevent relapses:Treatment should be continued for about 2 weeks beyond the disappearance of all signs of disease.

Canesten cream is odourless, can be washed off and does not stain.

Rectal

First infections: In general, a 3-day treatment is sufficient for Candida vaginitis. On 3 consecutive nights, Canesten 200 mg vaginal preparation is inserted as deeply as possible into the vagina. This is best achieved when lying on one's back with the knees slightly bent.

Re-infections: In general, a 6-day treatment is sufficient. This applies also to mixed infections with the above-mentioned causative organisms. On six consecutive nights, 1 Canesten 100 mgvaginal preparation is inserted as deeply as possible into the vagina. If necessary, 2 Canesten 100 mg(1 in the morning and 1 in the evening) or 1 Canesten 200 mg daily can be used for 6-12 days. Treatment should be timed so as to avoid the menstrual period and be finished before the onset of menstruation. To avoid re-infection, the partner should undergo local treatment with Canesten cream at the same time.

Canesten 500 mg vaginal preparation: Single dose, complete treatment with one vaginal tablet. The tablet should be inserted as deeply as possible into the vagina. This is best achieved when lying on one's back with the knees slightly bent. It is recommended that the treatment should be timed so as to avoid the menstrual period. For prevention of re-infection the partner should be treated locally with Canesten cream at the same time.

Canestenvaginal preparation are colorless and do not stain the underwear.

Eye

Adult: It should be applied thinly and evenly to the conjunctival sac every 4 hours daily or as advised by a physician.

Children: Safety and effectiveness in children have been established for Canesten when used as indicated and in the recommended dosage.

Ear

Instill 2-3 drops of Clarizol Ear Drops in the affected ear two or three times daily.The treatment should be continued for at least two weeks after the disappearance of all signs of infection to prevent re-infection.

For the treatment to become a complete success, reliable and sufficiently long application of Canesten cream is important. The duration of treatment varies; it depends among other factors on the extent and localisation of the disease.

Side Effects

Canesten is generally well tolerated after local application but the few side effects have been reported infrequently like erythema, stinging, blistering, peeling, oedema, pruritus, urticaria and general irritation.

Since there is practically no Canesten absorption through the vaginal skin, no systemic effect is expected. The local tolerance of Canesten vaginal tablet is generally good. Local irritation or burning sensation may occur in a very few cases but these symptoms are not considered harmful.

Rarely patients may experience burning or irritation immediately after applying the ointment.

Toxicity

Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps. As with all topical agents, skin sensitization may result .

Oral LD50 (rat): 708 mg/kg; Intraperitoneal LD50 (rat): 445 mg/kg; Subcutaneous LDLO (rat): 10 g/kg; Oral LD50 (mouse): 761 mg/kg; Subcutaneous LDLO (mouse): 10 g/kg; Intraperitoneal LD50 (mouse): 108 mg/kg;

Overdose

This drug poses no risk of acute intoxication, as it is unlikely to occur following a single vaginal or dermal application of an overdose (application over a large area under conditions favorable to absorption) or accidental oral ingestion. There is no specific antidote .

Effects on Fertility

No human studies of the effects of clotrimazole on fertility have been conducted; however, animal studies have not shown any effects on the drug on fertility .

Use in Pregnancy

There are limited data regarding the use of clotrimazole in pregnant women. Animal studies do not show direct or indirect harmful effects on reproduction. Although the topical application of clotrimazole may result in very low serum and tissue levels, the use of clotrimazole topical cream by pregnant women is not recommended unless it is advised by the prescribing physician. Canesten topical cream should not be used in the first trimester of pregnancy unless it is considered by the physician to be essential to patient well-being .

Use in Breastfeeding

Available pharmacodynamic/toxicological studies in animals have shown excretion of clotrimazole/metabolites in breastmilk. Canesten should not be administered during breastfeeding. Although the topical application of clotrimazole has resulted in very low serum and tissue levels, the use of clotrimazole topical cream by lactating women is not recommended unless it recommended by the prescribing physician .

Precaution

If local intolerance develops, consider withdrawal of the medicine and institution of appropriate therapy. Canesten solution is not intended for ophthalmic use. Avoid contact with eyes upon topical application. Children 3 yrs. Pregnancy, lactation. If irritation or sensitivity develops with the use of Canesten ointment, treatment should be discontinued.

Interaction

There have been reports of a heat reaction when this medication used concomitantly with Sofradex drops in the ear.

Antagonism with polyene antibiotics.

Food Interaction

No interactions found.

Canesten Disease Interaction

Moderate: hepatic dysfunction

Volume of Distribution

The topical form is minimally absorbed in the serum and tissues . Canesten is a lipophilic drug , and has been shown to be secreted in breastmilk in animal studies . There are limited data available regarding the volume of distribution following oral troche administration.

Elimination Route

Because clotrimazole is generally not significantly absorbed, drug interactions are not a major issue with its use .

Elimination Route

Mainly hepatic .

Pregnancy & Breastfeeding use

Pregnancy:Canesten is recommended during pregnancy only after first consulting a doctor.

Lactation:Because systemic absorption of clotrimazole following topical application is marginal, there should be no risk for the infant during lactation.

Contraindication

Hypersensitivity to clotrimazole.

Acute Overdose

Supportive measures should be taken incase of accidental oral ingestion.

In case of accidental oral ingestion, supportive measures should be taken.

Interaction with other Medicine

There have been reports of a heat reaction when this medication used concomitantly with Sofradex drops in the ear.

Storage Condition

Store at a cool and dry place. Protect from light. Do not freeze.

Innovators Monograph

You find simplified version here Canesten

Canesten contains Clotrimazole see full prescribing information from innovator Canesten Monograph, Canesten MSDS, Canesten FDA label

FAQ

What is Canesten used for?

Canesten is used to treat vaginal yeast infections, oral thrush, diaper rash, pityriasis versicolor, and types of ringworm including athlete's foot and jock itch. It is also used to treat skin infections such as athlete's foot, jock itch, ringworm, and other fungal skin infections (candidiasis). Canesten is used to treat skin infections caused by a fungus (yeast).

How safe is Canesten?

Food and Drug Administration and is safe and effective when used according to the Canesten facts label directions.

How does Canesten work?

Canesten work by killing the fungus (yeast) that is causing the infection. Canesten kills fungus by causing holes to appear in its cell membrane and the contents leak out.

What are the common side effects of Canesten?

Common side effects of Canesten are include: Burning, stinging, swelling, irritation, redness, pimple-like bumps, tenderness, or flaking of the treated skin may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Is Canesten safe during pregnancy?

Canesten is generally considered safe for pregnant women to use. If you are using the pessary to treat vaginal thrush during pregnancy it is recommended that you insert it with your fingers rather than with the applicator provided.

Is Canesten safe during breastfeeding?

Canesten is generally considered safe to use while you're breastfeeding. If your baby is being treated for oral thrush you can carry on breastfeeding but you'll need to be treated at the same time. Apply Canesten cream on and around your nipples after each time you breastfeed your baby.

Can I drink alcohol with Canesten?

Yes, you can drink alcohol while using Canesten.

When should be taken of Canesten?

Apply Canesten to the affected area 2 to 3 times a day. It will work better if you use it 3 times a day. If the affected area is large or hairy, it's best to use either the spray or solution.

Should Canesten be taken with food?

Do not eat or drink while Canesten is in your mouth.

How long does Canesten take to work?

Canesten usually takes 7 days for fungal infections to improve. Apply Canesten to the infected area 2 or 3 times a day for at least 2 weeks.

What is the half life of Canesten?

The elimination half-life of Canesten is 3.5-5 hours.

Can I take Canesten for long time?

Do not use Canesten cream, spray or solution for more than 4 weeks, unless a doctor tells you to.

What happens if I use too much Canesten?

Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. The risk is greater for children and patients who use large amounts for a long time.

When should I not use Canesten?

Do not use Canesten cream, spray or solution for more than 4 weeks, unless a doctor tells you to. A fungal infection can become resistant to Canesten, which means it will no longer work properly.

How many times a day can I use Canesten?

Adults and children use two times a day, morning and evening.

Does Canesten stop itching?

Canesten reduces vaginal burning, itching, and discharge that may occur with this condition.

Does Canesten raise blood sugar?

Canesten can raise blood glucose level by antagonizing the action and suppressing the secretion of insulin, which results in inhibition of peripheral glucose uptake and increased gluconeogenesis.

Can a man use Canesten cream?

Canesten can be used for men and women.

Will Canesten cure toenail fungus?

Over the counter fungal creams like Canesten don't work well for treating toenail fungus.

Does Canesten affect the liver?

The cause of the serum enzyme elevations during Canesten therapy is unknown, but many of the antifungal azoles have been implicated in causing liver injury.

Can I overdose on Canesten?

An overdose of Canesten topical is not expected to be dangerous. Seek emergency medical attention if anyone has accidentally swallowed the medication.

What happens if I stop taking Canesten?

Stopping the Canesten too early may allow fungus to continue to grow, which may result in a relapse of the infection. Inform your doctor if your condition persists or worsens.

Does Canesten dry out skin?

 Burning, tingling, dry skin, or stinging may occur.

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*** Taking medicines without doctor's advice can cause long-term problems.
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