Bexxar Uses, Dosage, Side Effects and more
Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine).
Bexxar binds to the CD20 antigen, which is predominantly expressed on mature B cells and on >90% of B-cell non-Hodgkin's lympohomas. The antibody leads to selective killing of B-cells.
| Attribute | Details |
|---|---|
| Trade Name | Bexxar |
| Availability | Prescription only |
| Generic | Tositumomab |
| Tositumomab Other Names | Tositumomab |
| Related Drugs | methotrexate, rituximab, glucagon, Rituxan, cyclophosphamide, mannitol, vincristine, Imbruvica, Tubersol |
| Type | |
| Formula | C6416H9874N1688O1987S44 |
| Weight | 143859.7 Da |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Bexxar is a monoclonal anti-CD20 antibody used to treat B-cell non-Hodgkin's lymphoma via a conjugated radioactive isotope.
For treatment of non-Hodgkin's lymphoma (CD20 positive, follicular)
How Bexxar works
Binds to the CD20 antigen which is found on mature B lymphocytes. The antibody binding appears to induce apoptosis, complement-dependent cytotoxicity and cell death through ionizing radiation.
Half Life
0.8 hours (mammalian reticulocytes, in vitro)
Clearance
- 68.2 mg/hr [patients with NHL]
Elimination Route
Elimination of Iodine-131 occurs by decay and excretion in the urine.
