Benzthiazid
Benzthiazid Uses, Dosage, Side Effects, Food Interaction and all others data.
Benzthiazid is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
| Trade Name | Benzthiazid |
| Availability | Discontinued |
| Generic | Benzthiazide |
| Benzthiazide Other Names | Benzothiazide, Benzotiazida, Benzthiazid, Benzthiazide, Benzthiazidum, Benztiazide |
| Related Drugs | amlodipine, lisinopril, metoprolol, losartan, furosemide, hydrochlorothiazide, spironolactone, Lasix, chlorthalidone, torsemide |
| Type | |
| Formula | C15H14ClN3O4S3 |
| Weight | Average: 431.937 Monoisotopic: 430.983495728 |
| Protein binding | 30% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment of high blood pressure and management of edema.
How Benzthiazid works
As a diuretic, benzthiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like benzthiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of benzthiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
Toxicity
Symptoms of overdose include nausea, vomiting, fatigue, urinary problems and drowsiness.
Benzthiazid Alcohol interaction
[Moderate]
Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during initiation of therapy and dose escalation.
Coadministration with antihypertensives and other hypotensive agents, in particular vasodilators and alpha-blockers, may result in additive effects on blood pressure and orthostasis.
Caution and close monitoring for development of hypotension is advised during coadministration of these agents.
Some authorities recommend avoiding alcohol in patients receiving vasodilating antihypertensive drugs.
Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia.
Benzthiazid Drug Interaction
Moderate: rasagiline, rasagiline, bisacodyl, bisacodylMinor: warfarin, warfarinUnknown: amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, epinephrine, epinephrine, starch topical, starch topical, candesartan / hydrochlorothiazide, candesartan / hydrochlorothiazide, rosuvastatin, rosuvastatin, multivitamin with iron, multivitamin with iron, rotigotine, rotigotine
Benzthiazid Disease Interaction
Elimination Route
Absorbed in the digestive tract.
Innovators Monograph
You find simplified version here Benzthiazid
