Axinat

Axinat Inhaler, Inhalation Capsule

Axinat stimulates intracellular adenyl cyclase, the enzyme that catalyses the conversion of ATP to cyclic-3',5'-adenosine monophosphate (cAMP) resulting in relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from mast cells.

Uses

Inhaled Axinat exerts a significant bronchodilating effect within 10 to 20 minutes of single-dose administration with asthma and this effect lasts for up to 12 hours or more.    Axinat has a beneficial effect on airway mucociliary clearance that will reduce the incidence of respiratory tract infections.    

Axinat produces a significant protective effect against Exercise Induced Asthma (EIA) for up to 9 to 12 hours in both adolescents and adults.    

Axinat improves the overnight PEFR (Peak Expiratory Flow Rate) and controls the symptoms of the patients with nocturnal asthma. The use of Axinat avoids exposure of children to theophylline or high-dose corticosteroid, with their attendants risks.     

Addition of Axinat to inhaled corticosteroid therapy is significantly more effective in terms of an improvement in lung function, symptom control and a reduction in the use of rescue bronchodilator therapy (use of short acting beta2-agonist).    

Addition of Axinat to inhaled corticosteroid therapy also significantly reduces the use of inhaled corticosteroids

Axinat is also used to associated treatment for these conditions: Asthma, Chronic Obstructive Pulmonary Disease (COPD), Exercise-Induced Bronchospasm

Axinat

Trade Name Axinat
Generic Salmeterol
Salmeterol Other Names Salmaterol, Salmeterol, Salmeterolum
Weight 25mcg/actu, 25mcg/metered inhalation, 25mcg
Type Inhaler, Inhalation Capsule
Formula C25H37NO4
Weight Average: 415.5656
Monoisotopic: 415.272258677
Protein binding

Salmeterol is 96% protein bound in plasma to albumin and alpha-1-acid glycoprotein.

Therapeutic Class Long-acting selective β2-adrenoceptor stimulants
Manufacturer Acme Laboratories Pakistan (pvt) Ltd,, Acme Laboratories Limited
Available Country Pakistan, Bangladesh
Last Updated: June 23, 2021 at 9:33 am

Structure

Axinat
Salmeterol Structure

Dosage

Axinat dosage

Inhalation/Respiratory-

Chronic asthma:

  • Adult: As metered dose aerosol or dry powder inhaler: 50 mcg bid, or up to 100 mcg bid if necessary, in asthma patients with more severe airways obstruction.
  • Child: 4-12 yr 50 mcg bid.

Prophylaxis of exercise-induced asthma:

  • Adult: As metered dose aerosol or dry powd inhaler: 50 mcg at least 30 min prior to exercise.
  • Child: ≥4 yr Same as adult dose.

Chronic obstructive pulmonary disease:

  • Adult: As metered dose aerosol or dry powder inhaler: 50 mcg bid.

Side Effects

Dose related tremor, subjective palpitations and headaches are usually mild and transient. Skin reactions, muscle cramps, non-specific chest pain, local irritation and arthralgia have been reported.

Precaution

Patient with CV disease, CNS disorders, DM, hyperthyroidism, hypokalaemia, seizure disorders, ketoacidosis. Not intended for the relief of acute bronchospasm. Hepatic impairment. Pregnancy and lactation.

Interaction

As with all the other beta2-agonists there may be interaction with betablocking agents at the receptor site when given concomitantly. 

Monoamino Oxidase Inhibitors and Tricyclic Antidepressants : These agent should be used with caution because Axinat may be potentiated by these agents.

Food Interaction

No interactions found.

Volume of Distribution

In asthmatic patients, the volume of distribution of the central compartment is 177L and the volume of distribution of the peripheral compartment is 3160L.

Half Life

The half life of salmeterol is 5.5h.

Clearance

The average clearance of salmeterol in a group of asthmatic patients was 392L/h. Further data regarding the clearance of salmeterol is not readily available.

Pregnancy & Breastfeeding use

Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Contraindication

Monotherapy in the treatment of asthma. Treatment of status asthmaticus, other acute episodes of asthma or COPD.

Special Warning

Hepatic Impairment: Because Axinat is extensively metabolised by the liver, patients with hepatic impairment receiving the drug should be closely monitored.

Acute Overdose

Symptoms: Dizziness, HTN or hypotension, tremor, headache, tachycardia, hypokalaemia, seizures, angina, arrhythmias, nervousness, muscle cramps, dry mouth, palpitations, nausea, fatigue, malaise, insomnia, hyperglycaemia, metabolic acidosis. 

Management: Symptomatic and supportive treatment. β-blockers may be considered but should be used with caution.

Storage Condition

Store between 20-25° C. Protect from heat or sunlight.

Innovators Monograph

Axinat contains Salmeterol see full prescribing information from innovator // generic/salmeterol/salmeterol-xinafoate-prescribing-information" Monograph

FAQ

What is Axinat used for?

Axinat is used to control wheezing, shortness of breath, coughing, and chest tightness in people with chronic obstructive pulmonary disease.

How safe is Axinat?

Axinat may increase the risk of asthma-related death. Use only the prescribed dose of this medication, and do not use it for longer than your doctor recommends. Follow all patient instructions for safe use. Talk with your doctor about your individual risks and benefits of using salmeterol inhalation.

What are the common side effects of Axinat?

Axinat may common side effects are include: 

  • shaking of a part of your body that you cannot control
  • headache
  • nervousness
  • dizziness
  • cough
  • stuffed nose
  • runny nose
  • ear pain
  • muscle pain, stiffness, or cramps
  • joint pain
  • sore, irritated throat
  • flu-like symptoms
  • nausea
  • heartburn
  • tooth pain
  • dry mouth
  • sores or white patches in the mouth
  • red or irritated eyes
  • difficulty falling asleep or staying asleep
  • burning or tingling of the hands or feet

Is Axinat safe during pregnancy?

Axinat has been considered a medication of choice if long-acting beta agonist treatment is needed during pregnancy. If a woman's asthma was well-controlled with Axinat before pregnancy, it may be recommended to continue using it during pregnancy.

Is Axinat safe during breastfeeding?

Using a Axinat inhaler is not thought to cause high enough levels in the mother's bloodstream to pass into breast milk in large amounts. Using inhaled bronchodilators is usually thought to be compatible with breastfeeding.

Can I drink alcohol with Axinat?

Yes, you can drink alcohol with Axinat.

Can I drive after taking Axinat ?

Monitor serum potassium level while taking Axinat. It may cause dizziness, do not drive a car or operate machinery while taking Axinat.

When should Axinat be taken?

Axinat is usually used twice a day, in the morning and evening, about 12 hours apart. Use Axinat at around the same times every day.

How long does it take for Axinat to work?

Axinat is called a long-acting bronchodilator. Its effects are usually felt within 20 minutes and last for around 12 hours.

Is Axinat a reliever?

Axinat is called a long-acting bronchodilator. It is usually used with both a fast-acting reliever and preventer medicine.

Is Axinat fast acting?

Axinat is a partial agonist, has a relatively slow onset of action (10 to 30 minutes)

Does Axinat increase blood pressure?

Axinat can increase heart rate, blood pressure, and cause chest pain and excitement, especially if used in higher doses than recommended or used in those with coronary heart disease or high blood pressure.

Can Axinat cause anxiety?

Possible side effects include nervousness, sweating, fast heartbeat, and anxiety.

Can I overdose on Axinat?

If this medication is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Does Axinat cause thrush?

Axinat may cause a fungus infection of the mouth or throat (thrush).

What happens if I miss a dose?

Skip the missed dose and continue your regular dosing schedule. Do not inhale a double dose to make up for a missed one.

Is Axinat inhaler a steroid?

Axinat a combination of a steroid plus a long-acting bronchodilator. fluticasone furoate(Trelegy Ellipta) a combination of a steroid, an anticholinergic, and a long-acting bronchodilator drug.

Can I stop using Axinat?

Do not stop using Axinat without talking to your doctor. If you suddenly stop using Axinat, your symptoms may worsen. Before you use the Axinat inhaler the first time, ask your doctor, pharmacist, or respiratory therapist to show you how to use it.

How do you stop taking Axinat?

Do not stop using Axinat inhalation without first talking to your doctor. Your asthma symptoms may get worse after you stop using the medication. If you also use a steroid medication, you should not stop using it suddenly. Follow your doctor's instructions about tapering your dose.