Avil Syrup, Tablet, Injection

Avil is an alkylamine derivative with histamine H1-receptor antagonist effects. It also has anticholinergic and moderate sedative effects.


Avil is a competitive H1 histamine receptor antagonist. Like other alkylamine antihistamines it is also antagonist of muscarinic cholinergic receptors and possesses local anesthetic properties. However, the concentration required for the latter effect is probably not achieved at therapeutic dose

Avil Maleate is used for allergic conditions (hypersensitivity reactions) such as:

  • Hay fever (pollinosis) with attacks of sneezing, itching, running of the nose, conjunctivitis.
  • Urticaria with pruritus and reddening, wealing and swelling of the skin.
  • Eczema of nervous origin (neurodermatitis) with pruritus.

Avil is also used to associated treatment for these conditions: Allergic Skin Reaction, Allergic urticaria, Anaphylaxis, Angioedema, Burns first degree, Common Cold, Congestion of the Conjunctivas, Dermatitis, Eczematous, Drug hypersensitivity reaction, Flu caused by Influenza, Insect Bites, Neurodermatitis, Ocular Irritation, Red eye, Seasonal Allergic Conjunctivitis, Sunburn, Urticaria

Trade Name Avil
Generic Pheniramine
Other Names Feniramina, Pheniramine, Pheniraminum
Weight 22.7mg, 15mg/5ml, 45.5mg/2ml, , 22.7mg/ml, 50mg, 25mg
Type Syrup, Tablet, Injection
Formula C16H20N2
Weight Average: 240.3434
Monoisotopic: 240.16264865
Therapeutic Class Sedating Anti-histamine
Manufacturer Sanofi, Sanofi Bangladesh Ltd,, Sanofi Aventis (pakistan) Ltd,, Aventis Pharma
Available Country India, Bangladesh, Australia, Pakistan, Indonesia,
Last Updated: June 23, 2021 at 9:00 am


Avil dosage

Unless otherwise prescribed by the doctor, the following dosages are recommended for the different dosage forms:

Avil Maleate Injection Solution: Except in life threatening conditions, the initial dose should be kept as low as possible: particularly in small children, a daily dose of 3 mg active substance per kg body weight should not be exceeded.

The following doses are administered once or twice daily:

  • Adults and Young people aged 12 years or over: 1.0-2.0 ml IV/IM.
  • Children aged 1-2 years (about 11-14 kg body weight): 0.5-0.7 ml IM only
  • Children aged 3-5 years (about 20 kg body weight): 0.8-1.3 ml IM only
  • Children aged 6-11 years (upto about 25 kg body weight): 1.0-1.5 ml IM only

Avil Maleate Injection (45.5 mg/2 ml)

: This is administered to adults and young people aged 12 years or over either slowly by intravenous route (1 ml per minute) or intramuscularly. To infants and children up to 12 years old the injection must only be given intramuscularly. The recommended dose may be repeated at 12 hourly intervals until acute symptoms have subsided. Avil Maleate can be combined with commercial calcium preparations but the compatibility should be tested in individual case.

Avil Maleate Tablet (22.7 mg): In adults and young people of over 12 years of age it is advisable to begin treatment with 1 tablet 2-3 times daily after meals. If necessary, the daily dose may be increased to 2 tablets 3 times daily from the second day of treatment onwards.

Avil Maleate Syrup (15 mg/5 ml): is particularly suitable for children. Children aged 1-3 years should receive half a measuring spoonful two or three times daily; children aged 4-12 years, 1 measuring spoonful 2 or 3 times daily; adults and young people 1-2 measuring spoonful of syrup twice or three times a day after meals. A daily dose of 3 mg/kg body weight must not be exceeded. Diabetics must bear in mind that Avil Maleate Syrup contains carbohydrates which are equivalent to 1.75 gm glucose per measuring spoonful (5 ml)

Avil Maleate Retard Tablet (75 mg): The coated tablets have a prolonged action. In most adults and adolescent over 12 years of age 1 coated tablet taken after supper is sufficient to produce an antihistaminic effect that for up to 24 hours. Only in very resistant cases will it be necessary to give an additional coated tablet in the morning after breakfast. The tablets are swallowed whole with a little liquid.


Side Effects

Occasionally there may be drowsiness, gastrointestinal complaints, dryness of mouth, palpitation, urinary retention or hypersensitivity reactions. In isolated cases, higher doses may produce hallucinations, restlessness or confusion; in small children, agitation.

In patients with narrow angle-glaucoma a rise in intraocular pressure is possible, which makes opthalmologic control necessary.

Even if used according to prescription, these preparations may reduce alertness to such an extent that the ability to cope with street traffic or operate machinery is impaired.


During pregnancy and lactation, pheniramine should be used only if strictly indicated, and after considering the benifit/risk ratio for mother and child.


The effect of drugs which act on the central nervous system (e.g. tranquilizers, sedatives, neuroleptic agents and MAO inhibitors) and of alcohol may be potentiated.

Food Interaction

No interactions found.

Half Life

The terminal half-life of pheniramine administered via IV is 8-17 h.

Pregnancy & Breastfeeding use

Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.


Hypersensitivity to pheniramine. The Syrup is contraindicated in patients hypersensitive to Methyl Hydroxybenzoate and Propyl Hydroxybenzoate. Prostatic hypertrophy with residual urine formation.

Acute Overdose

Symptoms: Agitation and convulsions (especially in children), and restlessness, disorientation and hallucinations in adults. Accidental ingestion in small children has resulted in convulsions and in some cases fatal.

Treatment: No specific antidote; symptomatic and supportive. Gastric lavage may be useful for some time after ingestion. Do not use stimulants. Diazepam or short-acting barbiturates may be used to control convulsions. Vasopressors may be used for hypotension.

Storage Condition

Keep all medicines out of the reach of children. To be dispensed only on the prescription of a registered physician. Do not use later than the date of expiry.