Aviglic

Aviglic Uses, Dosage, Side Effects, Food Interaction and all others data.

Aviglic stimulates the release of insulin from pancreatic beta-cells by facilitating Ca++ transport across the beta-cell membranes. It lowers blood glucose by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. Extrapancreatic effects also may play a part in the mechanism of action of oral sulfonylurea hypoglycemic drugs. Two extrapancreatic effects shown to be important in the action of Aviglic are an increase in insulin sensitivity and a decrease in hepatic glucose production. The anti-oxidant, platelet inhibiting and fibrinolytic actions of Aviglic involve processes which have been implicated in the pathogenesis of vascular complications of type 2 diabetes.

Based on the pharmacological properties, gliclazide is a second generation sulphonylurea which acts as a hypoglycemic agent. It stimulates β cells of the islet of Langerhans in the pancreas to release insulin. It also enhances peripheral insulin sensitivity. Overall, it potentiates insulin release and improves insulin dynamics.

Trade Name Aviglic
Generic Gliclazide
Gliclazide Other Names Gliclazida, Gliclazide, Gliclazidum
Type Tablet
Formula C15H21N3O3S
Weight Average: 323.41
Monoisotopic: 323.130362722
Protein binding

94%, highly bound to plasma proteins

Groups Approved
Therapeutic Class Sulfonylureas
Manufacturer Avinash Health Products Pvt Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Aviglic
Aviglic

Uses

Aviglic is used for control of blood glucose in patients with non-insulin dependent diabetes mellitus (Type-II, maturity onset diabetes mellitus) whose hyperglycemia cannot be controlled by diet alone.

Aviglic is also used to associated treatment for these conditions: Type 2 Diabetes Mellitus

How Aviglic works

Aviglic binds to the β cell sulfonyl urea receptor (SUR1). This binding subsequently blocks the ATP sensitive potassium channels. The binding results in closure of the channels and leads to a resulting decrease in potassium efflux leads to depolarization of the β cells. This opens voltage-dependent calcium channels in the β cell resulting in calmodulin activation, which in turn leads to exocytosis of insulin containing secretorty granules.

Dosage

Aviglic dosage

Adult: The usual initial dose of Aviglicis 40 to 80 mg daily, gradually increased, if necessary up to 320 mg daily until adequate control is achieved. A single dose should not exceed 160 mg. When higher doses are required it should be taken twice daily, according to the main meals of the day. For extended release tablet the initial recommended dose is 30 mg daily, even in elderly patients (>65 years); the daily dose may vary from 30 to 120 mg taken orally, once daily.

Aviglic extend release tablet should be taken with food because there is increased risk of hypoglycemia if a meal is taken late. It is recommended that the medication be taken at breakfast time. If a dose is forgotten, the dose taken on the next day should not be increased. Dose titration should be carried out in steps of 30 mg, according to the fasting blood glucose response. Each step should last for at least two weeks. Aviglic extend release tabletshould be neither broken nor chewed. Aviglic extend release tablet30 mg, can replace Aviglic 80 mg tabletsfor doses of 1 to 4 tablets per day.

Elderly: Plasma clearance of Aviglic is not altered in the elderly and steady state plasma levels are similar to those in adults under 65 years. Clinical experience in the elderly shows that it is effective and well tolerated.

Children: Aviglic as with other sulfonylureas is not indicated for the treatment of juvenile onset diabetes mellitus.

Side Effects

Hypoglycemia may occur in concurrent conditions such as hepatic & renal diseases, alcohol intoxication and adrenal and pituitary insufficiency. Mild gastro-intestinal disturbances including nausea, dyspepsia, diarrhea, and constipation have been reported but these types of adverse reactions can be avoided if Aviglic is taken during a meal. Allergic dermatological reactions including rash, prurits, erythema, bullous eruption have been reported during treatment with the drug but are not known to be directly attributable to it. More serious reactions like leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, hemolytic anemia, cholestatic jaundice, GI hemorrhage have not been reported with Aviglic.

Toxicity

LD50=3000 mg/kg (orally in mice). Aviglic and its metabolites may accumulate in those with severe hepatic and/or renal dysfunction. Symptoms of hypoglycemia include: dizziness, lack of energy, drowsiness, headache and sweating.

Precaution

Aviglic should be used carefully in patients with hepatic impairment. If there is definite hepatic disease then gliclazide should not be used. Consucon (Aviglic) can be used safely in patients with renal insufficiency as it is extensively metabolized. Consucon has less sudden hypoglycaemic episode than other sulfonylurea group of drugs.

Interaction

The hypoglycemic effect of Aviglic may be potentiated by NSAID (in particular aspirin), phenylbutazone, sulfonamides, coumarin derivatives, MAOIs, beta-adrenergic blockers, tetracyclines, chloramphenicol, clofibrate, cimetidine and miconazole tablets. Ingestion of alcohol may also increase the hypoglycemic effect of Aviglic. Some drugs may on the contrary, reduce its activity e.g. barbiturates, corticosteroides, thiazide diuretics, thyroid hormones, laxatives and oral contraceptives.

Food Interaction

  • Avoid alcohol.
  • Take with or without food. Consistent food intake reduces the risk of hypoglycemia.

Elimination Route

Rapidly and well absorbed but may have wide inter- and intra-individual variability. Peak plasma concentrations occur within 4-6 hours of oral administration.

Half Life

10.4 hours. Duration of action is 10-24 hours.

Elimination Route

Metabolites and conjugates are eliminated primarily by the kidneys (60-70%) and also in the feces (10-20%).

Pregnancy & Breastfeeding use

Pregnant Women: Aviglic should not be used in pregnant women although animal studies of Aviglic have not shown any teratogenic effect.

Nursing Mothers: This drug is contraindicated when breast feeding.

Contraindication

Hypersensitivity to sulfonylurea, diabetes complicated by ketoacidosis with coma, as a sole therapy of insulin-dependent (Type-1) diabetes mellitus, diabetes when complicated by pregnancy & breast-feeding.

Special Warning

Elderly: Plasma clearance of Aviglic is not altered in the elderly and steady state plasma levels are similar to those in adults under 65 years. Clinical experience in the elderly shows that it is effective and well tolerated.

Children: Aviglic as with other sulfonylureas is not indicated for the treatment of juvenile onset diabetes mellitus.

Acute Overdose

Symptoms: Hypoglycaemia with or without coma, convulsions or other neurological disorders.

Management: Carbohydrate intake, dosage adjustment and/or change of diet may be helpful. Admin rapid IV inj of concentrated glucose soln for hypoglycaemic coma.

Storage Condition

Store in a cool and dry place, below 30° C and away from light.

Innovators Monograph

You find simplified version here Aviglic

Aviglic contains Gliclazide see full prescribing information from innovator Aviglic Monograph, Aviglic MSDS, Aviglic FDA label

FAQ

What is Aviglic used for?

Aviglic is a sulfonylurea type of anti-diabetic medication, used to treat type 2 diabetes. It is used when dietary changes, exercise, and weight loss are not enough.

How safe is Aviglic?

Aviglic is safe to take for a long time. There's no evidence it harms your pancreas or your general health. But Aviglic may stop working properly after a while. Your doctor may then want to stop it or add a different medicine to help keep your blood sugar level stable.

How does Aviglic work?

Aviglic works by increasing the amount of insulin your body makes.

What are the common side effects of Aviglic?

Common side effects of Aviglic are include:

  • stomach ache or indigestion.
  • feeling sick (nausea)
  • being sick (vomiting) or diarrhoea.
  • constipation.


Is Aviglic safe during pregnancy?

Aviglic is not generally recommended in pregnancy and while breastfeeding. It's not clear whether Aviglic harms an unborn baby. For safety, your doctor will probably change your medicine to insulin before you become pregnant or as soon as you find out you're pregnant.

Is Aviglic safe during breastfeeding?

Aviglic is not generally recommended in pregnancy and while breastfeeding.

Can I drink alcohol with Aviglic?

Yes, you can drink alcohol while taking Aviglic, but it's best for men and women to drink no more than 2 units a day. Drinking more than this can increase the risk of low blood sugar.

Can I drive after taking Aviglic?

If your blood sugar levels are stable, your ability to drive, cycle or use machines or tools should not be affected by Aviglic. But if your blood sugar levels become too low, this can reduce your concentration. If this happens to you, do not drive, cycle or use machines or tools until you feel better.

When should be taken of Aviglic?

If you take Aviglic once a day, it's best to take it in the morning with breakfast. Aviglic can sometimes make your blood sugar level too low . Carry some sweets or fruit juice with you to help when this happens.

Can I take Aviglic on an empty stomach?

Aviglic tablets should be taken before food , either with breakfast or the first main meal of the day.

How long does Aviglic take to work?

When taken 30 minutes before breakfast, Aviglic produced a peak of IRI 30 minutes after the meal; taken immediately before or after, it took twice to three times as long to produce an IRI peak.

How long does Aviglic last in the body?

Aviglic is more effective when administered about 30 minutes before a meal. Blood sugar control persists for up to 24 hours following a single dose, even though levels of Aviglic in the blood are barely detectable.

How often can I take Aviglic?

For standard-release Aviglic, the maximum daily dose is 320mg. If you need to take more than 160mg a day, take the tablets twice a day with your morning and evening meals.

Who should not take Aviglic?

Aviglic is only for adults. Do not give this medicine to children under 18 years.

What happen If I missed Aviglic?

If you missed a dose of Aviglic, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not take two doses together to make up for a missed dose.

What happen if I overdose of Aviglic?

Never take more than the prescribed dose of Aviglic. If you suspect that you might have taken an overdose of this medicine, go to the nearest emergency medical department/hospital.

Can Aviglic affects my heart ?

If you have problems with the heart and blood vessels, use Aviglic with caution as it can increase the risk of heart failure.

Will Aviglic affect my fertility?

There's no firm evidence to suggest that taking Aviglic will reduce fertility in either men or women.

Does Aviglic affect kidney function?

Aviglic can be considered in renal impairment if appropriate attention is paid to the dose.

Can Aviglic cause liver damage?

This case strongly suggests that Aviglic can induce acute icteric liver necro-inflammation which may be misdiagnosed clinically as acute viral hepatitis. In patients who show abnormal liver function tests, the immediate discontinuation of Aviglic is recommended.

*** Taking medicines without doctor's advice can cause long-term problems.
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