Aviflu Capsule

Aviflu is fungistatic in action. It inhibits cytochrome P-450 14-α demethylase in susceptible fungi which leads to accumulation of lanosterol and decreased concentration of ergosterol thereby altering cellular membrane resulting in increased membrane permeability, leakage of essential elements and impaired uptake of precursor molecules to DNA.


For the treatment of fungal corneal ulcers/ keratitis.

Aviflu is also used to associated treatment for these conditions: Candida intertrigo, Candida pneumonia, Candida urinary tract infection, Candidemia, Candidiasis, Coccidioidomycosis, Esophageal Candidiasis, Fungal peritonitis caused by Candida, Infections, Fungal, Meningitis, Cryptococcal, Oropharyngeal Candidiasis, Peritoneal candidiasis, Pneumonia cryptococcal, Pruritus, Skin Irritation, Systemic Candida Infections caused by Candida, Vaginal Candidiasis, Disseminated Candidiasis

Trade Name Aviflu
Generic Fluconazole
Other Names Diflucan, Difluconazole, Fluconazol, Fluconazole, Fluconazolum, Triflucan
Weight 75mg
Type Capsule
Formula C13H12F2N6O
Weight Average: 306.2708
Monoisotopic: 306.104065446
Protein binding

The protein binding of fluconazole is low and estimated to be 11 to 12%.

Therapeutic Class Ophthalmic Anti-fungal Products
Manufacturer Avalanche Pharmaceuticals, Square Pharmaceuticals Ltd
Available Country India, Bangladesh
Last Updated: June 23, 2021 at 9:00 am


Aviflu dosage

Instill 1 drop to be instilled into the affected eye(s) 5 times daily.

Side Effects

This drug is generally well tolerated. Eosinophillia has been reported in some patients.


Use of fluconazole may result in overgrowth of non-susceptible strains of candida other than Candida albicans


Aviflu can alter pharmacokinetics of certain drugs undergoing hepatic metabolism.

Food Interaction

  • Take with or without food. The absorption is unaffected by food.

Volume of Distribution

The apparent volume of distribution is said to be similar to the volume of distribution of total body water. One clinical study of healthy volunteers administered 50 mg/kg of fluconazole was 39L, based on a body weight of 60kg.

Aviflu shows substantial penetration in many body fluids, which is a property that renders it an ideal treatment for systemic fungal infections, especially when administered over a longer time. Aviflu is found in high concentrations in the stratum corneum and dermis-epidermis of skin, in addition to eccrine sweat. Aviflu is found to accumulate especially well in the stratum corneum, which is beneficial in superficial fungal infections.[L6496] Saliva and sputum concentrations of fluconazole are found to be similar to the plasma concentrations. In patients diagnosed with fungal meningitis, fluconazole CSF (cerebrospinal fluid) levels are measured to be about 80% of the corresponding plasma levels. Therefore, fluconazole crosses the blood-brain barrier[L6496]. The meninges are increasingly permeable to fluconazole in states of inflammation, facilitating treatment in meningitis.

Half Life

The terminal elimination half-life in the plasma is approximately 30 hours (range: 20-50 hours) after oral administration. The long plasma elimination half-life supports a single dose therapy for vaginal candidiasis, once daily and once weekly dosing for other indications.[L6496]. Patients with renal failure may require dosage adjustment, and half-life can be significantly increased in these patients.


This drug is mainly eliminated by the kidneys and the mean body clearance in adults is reported to be 0.23 mL/min/kg. One clinical study of healthy subjects showed total clearance of 19.5 ± 4.7 mL/min and renal clearance of 14.7 ± 3.7 mL/min (1.17 ± 0.28 and 0.88 ± 0.22 L/h).

Clearance in the pediatric population varies according to age, as does clearance in patients with renal failure.

Pregnancy & Breastfeeding use

Use in pregnancy: Pregnancy category C. There are no adequate and well-controlled studies in pregnant women. Aviflu should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Use in lactation: Nursing mother should not be given as the drug is excreted in breast milk in concentration similar to plasma.


The drug is contraindicated in patients with hypersensitivity to azoles.

Storage Condition

Keep out of the reach of children. Store in a cool, dry place, away from heat and direct light. Do not use more than 4 weeks after opening the bottle


What does Aviflu used for?

Aviflu is used to prevent and treat a variety of fungal and yeast infections like mucocutaneous candidiasis, including esophageal candidiasis (infection of the esophagus), oropharyngeal candidiasis (infection of part of the throat), cryptococcal meningitis and vulvovaginal candidiasis (infection of the vulva and vagina). It belongs to a class of drugs called azole antifungals. It works by stopping the growth of certain types of fungus. Treat to Prevent candidiasis in people undergoing bone marrow transplantation who are receiving chemotherapy and/or radiation. 

How quickly does Aviflu work?

Aviflu begins resolving symptoms in 4 hours, with complete resolution in as soon as 16 hours for uncomplicated cases. More complex cases or repeated infections may require longer treatment durations to achieve complete resolution.

Is Aviflu an antibiotic?

Aviflu belongs to a group of medicines called azole antibiotics. It works by preventing the growth of the fungal and yeast organisms causing your infection.

What should I avoid while taking Aviflu?

Common medications that may interact with Aviflu include: anticoagulants or antiplatelet agents (blood thinners), such as warfarin, clopidogrel, (may prolong bleeding time) biologics, such as acalabrutinib, bosutinib, or entrectinib. albuterol.

How long does a yeast infection last after taking Aviflu?

Aviflu is used for many different fungal infections. If you have vaginal thrush, balanitis or oral thrush, your symptoms should be better within 7 days of taking Aviflu.

Can I take two doses of Aviflu?

Single-dose Aviflu is highly effective in complicated Candida vaginal infections, the clinical cure rate is better when a second sequential dose is used.

How do I know when yeast infection is clearing up?

  • First, you will notice that vaginal discharge has returned to a normal consistency and smell.
  • Second, you will notice that itching has gone away, alleviating much of the discomfort associated with the infection.
  • Third, you will notice that any rash, swelling, or redness has subsided. Your genitals should return to a healthy appearance and feel.

How Long Does a Yeast Infection Last?

If a mild yeast infection is left untreated, it may go away on its own in a few days. More severe yeast infections could take up to 2 weeks to clear without treatment. If your infection is causing painful and uncomfortable symptoms for more than 3 days, you should seek medical treatment.

What Is a Yeast Infection?

A yeast infection, also known as candida vulvovaginitis, is a common infection that 3 out of 4 women will experience throughout their lives. Yeast infections are not considered sexually transmitted infections (STIs). Every woman’s vagina has a delicate balance of live bacteria and yeast cells. When this balance is thrown off, yeast cells can multiply, which may result in a yeast infection.

How do I know if I have a yeast infection?

The most common symptoms of vaginal yeast infection include:

  • Stinging sensations in the vagina or vulva
  • Persistent itchiness in the genital area
  • Pain during intercourse
  • Pain during urination
  • Stinging sensations in the vagina or vulva
  • Pain during intercourse
  • What does a yeast infection look like?
  • Thick, lumpy vaginal discharge
  • Redness in the vagina and vulva
  • Swelling of the labia and vulva
  • smell like Strong, musty odor, Fishy, sour odor or abnormal smell

How long does it take to recover from Yeast infection?

Without treatment, it takes 3–7 days to recover from a yeast infection. It can take 1–2 weeks to recover from a moderate to severe yeast infection.

What happens if I stop taking Aviflu?

Do not stop taking Aviflu without talking to your doctor. If you stop taking Aviflu too soon, your infection may come back after a short time.

What are the side effects of Aviflu?

Aviflu Side Effects are

  • Chills.
  • general feeling of tiredness or weakness.
  • hives, itching, or skin rash.
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals.
  • light-colored stools.
  • stomach pain, continuing.
  • upper right abdominal or stomach pain.
  • yellow eyes and skin.

What infections does Aviflu treat?

Aviflu is used to treat serious fungal or yeast infections, such as vaginal candidiasis, oropharyngeal candidiasis (thrush, oral thrush), esophageal candidiasis (candida esophagitis), other candida infections (including urinary tract infections, peritonitis [inflammation of the lining of abdomen or stomach], and infections that may occur in different parts of the body), or fungal (cryptococcal) meningitis. This medicine works by killing the fungus or yeast, or preventing its growth.

Aviflu is also used to prevent candidiasis in patients having bone marrow transplants who receive cancer or radiation treatment.

What is the best time of day to take Aviflu?

Aviflu can be taken at any time of day, and can be taken either before or after a meal. Swallow the capsule with a drink of water. Infections such as vaginal thrush can be treated with a single 150 mg dose; other infections require a course of treatment possibly lasting a number of weeks.

Can I drink milk while taking Aviflu?

Any condition that makes it hard for you to digest sugars or dairy products so take with caution. The capsule form of Aviflu contains lactose (milk sugar) and the oral liquid contains sucrose (table sugar), which can make these conditions worse.

How much Aviflu should I take for a yeast infection?

The treatment of choice is a single 150 mg oral fluconazole (Aviflu). Most women consider the pill more convenient than creams applied intravaginally. A cool fact is that a single 150 mg dose of Aviflu maintains therapeutic concentrations in vaginal secretions for at least 72 hours after you take it.

Can men take Aviflu?

Men with severe yeast infections or those involving the penis may need to take an antifungal in pill form, like fluconazole (Aviflu), which is available by prescription from your doctor.

Can sperm cause yeast infections?

But sometimes sexual activity can lead to vaginitis. Your partner's natural genital chemistry can change the balance of yeast and bacteria in your vagina. In rare cases, you can have an allergic reaction to your partner's semen.

Why do I keep getting yeast infections from my boyfriend?

Intercourse introduces bacteria from your partner's finger or penis into your vagina's ecosystem of bacteria and Candida. Sex toys can also transmit it. This disruption may be enough to trigger a vaginal yeast infection.

Is it bad to scratch when I have a yeast infection?

Even though yeast infections can be really itchy, try not to scratch. It can make irritation worse or cause cuts in your skin, which can spread germs and lead to more infection. There are over-the-counter creams that you can use on your vulva to help calm the irritation.

Which is better clotrimazole or (Aviflu) fluconazole?

Fluconazole (Aviflu) can more successfully and safely cure clinical and micrological symptom of VVC than clotrimazole and can be more effective in reduction of the relapse rate of the disease than clotrimazole.