Avamys Nasal Spray

Avamys is a synthetic trifluorinated corticosteroid with potent anti-inflammatory activity. Like other corticosteroids Avamys is found to have a wide range of actions on multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, lymphocytes) and mediators (e.g.- histamine, eicosanoids, leukotrienes, cytokines) involved in inflammation.


Avamys nasal spray is used for the treatment of the symptoms of seasonal and perennial allergic rhinitis in patients aged 2 years and older.

Avamys is also used to associated treatment for these conditions: Asthma, Bacterial Sinusitis, Chronic Obstructive Pulmonary Disease (COPD), Chronic Sinusitis, Perennial Allergic Rhinitis (PAR), Seasonal Allergic Rhinitis

Trade Name Avamys
Generic Fluticasone Furoate
Other Names Fluticasone furoate, Fluticasonum furoas, Furoate de fluticasone, Furoato de fluticasona
Weight 27.5mcg/actuation,
Type Nasal Spray
Formula C27H29F3O6S
Weight Average: 538.576
Monoisotopic: 538.163693965
Protein binding

Fluticasone furoate is >99% protein bound in serum and may be as high as 99.6%.

Therapeutic Class Nasal Steroid Preparations
Manufacturer Glaxosmithkline Pharma, Glaxosmithkline, Glaxosmithkline Uk, Glaxo Group Ltd
Available Country India, Bangladesh, United Kingdom, Canada, Australia, United States, France, Italy, Netherlands, Spain,
Last Updated: June 23, 2021 at 9:00 am


Avamys dosage

Adults & Children over 12 years: 2 sprays in each nostril once a day. In some cases 2 sprays into each nostril twice daily, not exceeding 4 sprays.

Children under 12 years (2-11 Years): 1 spray in each nostril once a day.  Patients should use Avamys nasal spray at regular intervals as directed since its effectiveness depends on its regular use.

Children (under 2 years of age): There are no data to recommend use of Avamys Nasal Spray for the treatment of seasonal or perennial allergic rhinitis in children under 2 years of age.

How to use the Nasal Spray

  • Shake the bottle gently and remove the dust cover.
  • Hold the spray with your forefinger and middle finger on either side of the nozzle and your thumb underneath the bottle. If using for the first time or if you have not used it for a week or more, press the nasal applicator several times until a fine mist comes out from the container.
  • Gently blow the nose to clear the nostrils.
  • Close one nostril and carefully insert the nasal applicator into the open nostril. Tilt your head forward slightly and keep the spray upright. Breathe in through your nose and while breathing in, press the white collar of nasal applicator firmly down once to release a spray.
  • Breathe out through your mouth.
  • Repeat the above steps in the same/other nostril for consecutive doses.

Side Effects

Eosinophilic conditions, adrenal insufficiency, growth retardation, Cushing's syndrome, decreased bone density, cataract, glaucoma. Rarely, psychological effects.


Patients taking Avamys nasal spray should be periodically monitored for signs of adverse effects on the nasal mucosa such as epistaxis, nasal ulceration and impaired wound healing. Avoid using the drug in patients with recent nasal ulcers, nasal surgery, or nasal trauma. Closely monitor patients with a history of increased intraocular pressure, glaucoma and hypersensitivity reactions (including anaphylaxis, angioedema, rash, and urticaria). Besides, potential worsening of existing fungal, bacterial, viral, or parasitic infections or ocular herpes simplex, hypercorticism and growth retardation may occur after the administration of Avamys nasal spray.


Potent inhibitors of cytochrome P450 3A4 (CYP3A4) may increase exposure to Avamys. Coadministration of ritonavir is not recommended. Use caution with coadministration of other potent CYP3A4 inhibitors, such as ketoconazole. 

Special instruction: Patients should be instructed that the device must be primed: before first use, and if the cap is left off or if the device does not seem to be working or if the nasal spray has not been used for 30 days or more. In order to prime the device, the nasal spray needs to be shaken vigorously for about 10 seconds with the cap on. The patient must then press the button firmly all the way in, approximately 6 times until a fine mist is seen. Once primed, the patient must shake the nasal spray vigorously each time before use.

Food Interaction

No interactions found.

Volume of Distribution

608L at steady state for intravenous administration of fluticasone furoate. Other reports suggest the mean volume of distribution at steady state is 661L. A study of 24 healthy Caucasian males showed a volume of distribution at steady state of 704L following intravenous administration.

Half Life

15.1 hours for intranasal fluticasone furoate and 24 hours for the inhaled formulation. A study of 24 healthy Caucasian males showed a half life of 13.6 hours following intravenous administration and 17.3-23.9 hours followed inhalation.


57.8L/h for fluticasone furoate. A study of 24 healthy Caucasian males showed a clearance of 71.8L/h following intravenous administration.

Pregnancy & Breastfeeding use

Pregnancy: Plasma Avamys concentrations were typically non-quantifiable and therefore potential for reproductive toxicity is expected to be very low.

Lactation: The excretion of Avamys into human breast milk has not been investigated.


Avamys nasal spray is contraindicated in patients with a hypersensitivity to any of its ingredients.

Special Warning

Pediatric use: The safety and effectiveness of Avamys in children younger than 2 years have not been established. 

Geriatric use: In general, dose selection for the elderly patient should be cautious, keeping in mind the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. 

Use in hepatic impairment: Use Avamys with caution in patients with severe hepatic impairment. 

Use in renal impairment: No dosage adjustment is required in patients with renal impairment.

Storage Condition

  • Store at a temperature not exceeding 30 °C.
  • Do not refrigerate.
  • Protect from light and moisture.
  • Keep out of the reach of children.

Avamys contains Fluticasone Furoate see full prescribing information from innovator Monograph


What does Avamys used for?

Avamys is an antibiotic. It's used to treat skin and wound infections, chest infections, such as pneumonia, and bone infections (osteomyelitis). Avamys is used in children, often to treat ear infections and chest infections. The medicine is available only on prescription.

What bacteria does Avamys kill?

Bactericidal activity of Avamys against Staphylococcus aureus in primary keratinocyte cultures of lesional and unaffected skin of patients suffering from atopic dermatitis.

What does Avamys do to the body?

Avamys belongs to a group of antibiotics called penicillins. It works by interfering with the formation of the bacterial cell walls. Avamys impairs the bonds that hold the bacterial cell wall together, which allows holes to appear in the cell walls. This kills off the bacteria causing the infection.

Is Flucloxacillin the same as amoxicillin?

Amoxicillin acts against gram-negative and gram-positive organisms except those producing [3-1actamases, and flucloxacillin has its prominent range of activity among gram-positive strains including ~-lactamase producers.

What happens if I take Avamys with food?

You should take Avamys 'on an empty stomach', which means you should take it about an hour before a meal, or wait until two hours afterwards. This is because your body absorbs less Avamys after a meal, which means the medicine is less effective. Space the doses out evenly during the day.

Can I take paracetamol and Avamys?

Both flucloxacillin and paracetamol can increase the risk of hepatotoxicity. Paracetamol potentially increases the risk of high anion gap metabolic acidosis when given with flucloxacillin. Manufacturer advises caution.

How long can I take Avamys?

Doctor will advise you on how long to take Avamys for (usually 5 to 7 days). Always take your Avamys exactly as your doctor has told you. The pharmacy label on your medicine will tell you how much to take, how often to take it, and any special instructions.

Can Avamys cause liver damage?

The short-term risk of laboratory-confirmed liver injury was >5-fold higher after a Avamys prescription than an oxytetracycline prescription. The risk of flucloxacillin-induced liver injury is particularly high within those aged >70 and those who receive multiple Avamys prescriptions.

Does Avamys safe?

Avamys is normally a safe drug. It is unlikely to cause any problems if you give an extra dose by mistake. If you think your child may have had too much Avamys, contact your doctor.

Do Avamys make me tired and weak?

If you're taking prescription antibiotics, you may feel tired and fatigued. This may be a symptom of the infection being treated by the antibiotics, or it may be a serious, but rare, side effect of the antibiotic. Learn more about how antibiotics may affect your body, and what you can do to counteract these effects.

What class of antibiotic is Avamys?

It is a narrow-spectrum beta-lactam antibiotic of the penicillin class. It is similar in effect to cloxacillin and dicloxacillin, being active against penicillinase forming bacteria. Flucloxacillin was patented in 1961.