Atenolol Tablet, Intravenous
The synthesis of atenolol resulted from attempts to produce a β-adrenoceptor antagonist that would competitively block β1 (cardiac) receptors but have no effect on β2-receptors. It is classified as a β1 selective (cardioselective) β-adrenergic receptor antagonist with no membranestability activity and no partial agonist activity. It is markedly the most hydrophilic of the currently available β- blockers and thus penetrates the lipid of cell membranes poorly
Atenolol is used for: Hypertension, Angina pectoris, Cardiac arrhythmia, Myocardial infarction
Atenolol is also used to associated treatment for these conditions: Alcohol Withdrawal Syndrome, Angina Pectoris, Atrial Fibrillation, Heart Failure, High Blood Pressure (Hypertension), Migraine, Myocardial Infarction, Refractory Hypertension, Secondary prevention Myocardial infarction, Supra-ventricular Tachyarrhythmias, Thyrotoxicosis, Ventricular Tachyarrhythmias
|Other Names||Atenolol, Atenololum|
6-16% bound in plasma. Atenolol binds to two sites on human serum albumin.
|Therapeutic Class||Beta-adrenoceptor blocking drugs, Beta-blockers|
|Manufacturer||Zafa Pharmaceutical Laboratories (pvt) Ltd, , Albion Pharmaceuticals Ltd, Amico Laboratories Ltd, Accord Healthcare Limited, Pt Pratapa Nirmala, Ecomed Pharma Ltd, Alpa Laboratories Pvt Ltd|
|Available Country||Pakistan, Bangladesh, United Kingdom, United States, Indonesia, Netherlands, Nigeria, India|
|Last Updated:||June 23, 2021 at 9:29 am|
Table Of contents
Hypertension: 50 mg once daily, the daily dose can be raised to 100 to 200 mg.
Angina pectoris: 50 to 100 mg daily.
Cardiac arrhythmia: Atenolol in low dose, 25-50 mg once daily, can be used in combination with digoxin to control the ventricular rate in atrial fibration or atrial flutter which is refractory to digoxin alone.
In general, atenolol is well tolerated although in a small number of patients (approximately 2-3%) therapy must be withdrawn because of troublesome symptomatic adverse effects. The commonest of these are cold extrimities, fatigue, vivid dreams, insomnia, diarrhoea, constipation, impotence and paraesthesia. Bronchospasm has been occurred with atenolol although this is very much less common than with the non-selective β-blockers.
Patients already on a β-blocker must be evaluated carefully before Atenolol is administered. Atenolol may aggravate peripheral arterial circulatory disorders. Impaired Renal Function: Caution should be excised.
Catecholamine-depleting drugs (e.g., Reserpine) and Calcium channel blockers may have an additive effect when given with Atenolol. Clonidine and aspirin may have some drug reactions.
Food InteractionNo interactions found.
Volume of Distribution
Total Vd of 63.8-112.5 L. Atenolol distributes into a central volume of 12.8-17.5 L along with two peripheral compartments with a combined volume of 51-95 L. Distribution takes about 3 hrs for the central compartment, 4 hrs for the shallower peripheral compartment, and 5-6 hrs for the deeper peripheral compartment.
Total clearance is estimated at 97.3-176.3 mL/min with a renal clearance of 95-168 mL/min.
Pregnancy & Breastfeeding use
Pregnancy Category D. Caution should be exercised when Atenolol is administered to a nursing woman.
Atenolol is contraindicated for: Second and third degree heart block, Untreated heart failure, Overt cardiac failure, Cardiogenic shock.
Safety and effectiveness in pediatric patients have not been established.
Overdosage with Atenolol has been reported with patients surviving acute doses as high as 5 gm. One death was reported in a man who may have taken as much as 10 gm acutely.
What is Atenolol used for?
Atenolol is used for the relief of pain and inflammation in both acute and chronic pain like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, dental pain, post-traumatic pain, low back pain, gynaecological pain etc.
Is Atenolol is a painkiller?
Anti-inflammatory painkillers like Atenolol are also called non-steroidal anti-inflammatory drugs (NSAIDs), or sometimes just 'anti-inflammatories'. Atenolol is prescribed for people with painful rheumatic conditions such as osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
How safe is Atenolol?
Atenolol 100 mg orally twice daily, is a safe, effective, and convenient treatment for active AS.
Is Atenolol safe for kidneys?
Patients with mild to moderate renal impairment should be kept under surveillance, since the use of NSAIDs may result in deterioration of renal function. The lowest effective dose should be used and renal function monitored regularly. Effects on renal function are usually reversible on withdrawal of Atenolol.
Who should not take Atenolol?
Atenolol is not recommended if you have asthma or a history of asthma in your family. Impaired function of the kidney- Atenolol is not recommended if you have impaired kidney function. Impaired function of the liver- Use with caution with an initial dose of 100 mg once daily for mild liver failure.
Can Atenolol used for teeth pain?
Atenolol has anti-inflammatory properties similar to those of diclofenac and yields good results in the control of dental pain.
Does Atenolol make me sleepy?
It may cause dizziness, drowsiness or visual disturbances. Use caution while driving or doing anything that requires concentration. Avoid consuming alcohol while taking Atenolol as it can cause excessive drowsiness and increase your risk of stomach problems.
Does Atenolol increase blood pressure?
Atenolol may oppose the blood pressure lowering effects of certain medicines to treat high blood pressure, including the following: ACE inhibitors such as captopril.
Is Atenolol a muscle relaxant?
Atenolol is a non-steroidal anti-inflammatory drug (NSAID) which works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). Thiocolchicoside is a muscle relaxant.
What is the Dosage of Atenolol?
Adults: The maximum recommended dose is 200 mg daily, taken as two separate 100 mg doses, one tablet in the morning and one in the evening.
Children: There is no clinical data on the use of Atenolol in children.
Elderly: The pharmacokinetics of Atenolol are not altered in elderly patients, therefore it is not considered necessary to modify the dose and dose frequency.
Renal insufficiency: There is no evidence that the dosage of Atenolol needs to be modified in patients with mild renal impairment.
Hepatic insufficiency: The dose of Atenolol should be reduced in patients with hepatic impairment. An initial daily dose of 100 mg should be administered.
Atenolol SR tablet:
The recommended dose is 200 mg once daily.
What is the Side Effects of Atenolol?
Generally Atenolol is well tolerated. The majority of side effects observed have been reversible and of a minor nature and include gastrointestinal disorders (dyspepsia, abdominal pain, nausea and diarrhoea) and occasional occurance of dizziness. Dermatological side effects including pruritus and rash. Abnormal hepatic enzyme levels and raised serum creatinine have occasionally been reported.
Is Atenolol safe during pregnancy?
There is no information on the use of Atenolol during pregnancy. Atenolol should not be administered during pregnancy, unless there are compelling reasons for doing so. The lowest effective dose should be administered.
Is Atenolol safe during breastfeeding?
There is no information on the secretion of Atenolol in breast milk. The use of Atenolol should therefore be avoided during lactation unless the potential benefits to the mother outweigh the possible risks to the children.