Aslor Syrup, Tablet

Aslor is a long-acting, tricyclic, non-sedating, selective peripheral histamine H1-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils.

Uses

Allergic Rhinitis: Aslor is used for the relief of the nasal and non-nasal symptoms of allergic rhinitis (Both seasonal and perennial) in patients 2 years of age and older.

Chronic Idiopathic Urticaria: Aslor is also used for the symptomatic relief of pruritus, reduction in the number of hives, and size of hives, in patients with chronic idiopathic urticaria 2 years of age and older.

Aslor is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Asthma, Chronic Idiopathic Urticaria, Common Cold, Nasal Congestion, Perennial Allergic Rhinitis (PAR), Seasonal Allergic Rhinitis, Nasal symptoms, Non-nasal symptoms, Antihistamine

Trade Name Aslor
Generic Desloratadine
Other Names Descarboethoxyloratadine, Desloratadina, Desloratadine
Weight 2.5mg/5ml, 5mg
Type Syrup, Tablet
Formula C19H19ClN2
Weight Average: 310.821
Monoisotopic: 310.123676325
Protein binding

Desloratadine is bound approximately 82 to 87% to plasma proteins, while its active metabolite, 3-hydroxydesloratadine, is bound approximately 85 to 89%.

Therapeutic Class Non-sedating antihistamines
Manufacturer Drug International Ltd
Available Country Bangladesh
Last Updated: June 23, 2021 at 11:19 am

Dosage

Aslor dosage

Pediatric drops :

  • Child 6 -11 months of age: 2 ml drops once daily
  • Child 1 -2 years of age: 2.5 ml drops once daily

Syrup:

  • Child 6-11 months of age: 2 ml once daily
  • Child 1-5 years of age: 2.5 ml once daily
  • Child 6-11 years of age: 5 ml once daily
  • Adults & > 12 years of age: 10 ml once daily

Tablet: 

  • Adults and children 12 years of age and over: 5 mg daily

Side Effects

Aslor is generally well tolerated. However, dry mouth, fatigue, somnolence and myalgia are commonly reported side-effects. Less common side-effects may include dizziness, headache and nausea. Rarely rash, pruritus and urticaria may occur.

Precaution

Hepatic and renal impairment. Pregnancy and lactation.

Interaction

Concomitant administration of Erythromycin, Ketoconazole, Azithromycin, Fluoxetine, and Cimetidine with Aslor increased the plasma concentration of Aslor. But there were no clinically relevant changes in the safety profile of Aslor.

Food Interaction

  • Take with or without food. The absorption is unaffected by food.

Half Life

Aslor has a mean plasma elimination half-life of approximately 27 hours.

Pregnancy & Breastfeeding use

Pregnancy: There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, Aslor should be used in pregnancy only if clearly needed. 

Lactation: Aslor passes into breast milk. Therefore, a decision should be made whether to discontinue nursing or to discontinue Aslor, taking into account the importance of the drug to the mother.

Contraindication

Aslor is contraindicated in patient having hypersensitivity to this medication or to any of its ingredients or Loratadine.

Special Warning

Paediatric Use: The safety and effectiveness of Aslor in pediatric patients under 2 years of age have not been established.

Geriatric Use: In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

In adult patients with liver or renal impairment: A starting dose of one 5 mg tablet every other day is recommended based on pharmacokinetic data.

Acute Overdose

No clinically relevant adverse events have been reported in case of overdosage. However, in the event of overdosage, symptomatic and supportive treatment is recommended.

Storage Condition

Store in a cool and dry place, protected from light.

Aslor contains Desloratadine see full prescribing information from innovator Monograph