Aslan Capsule

Aslan is a substituted benzimidazole, and is also known as PPI due to its property to block the final step of acid secretion by inhibiting H+/K+ ATPase enzyme system in gastric parietal cell. Both basal and stimulated acid are inhibited.


Aslan is used for:

  • Short term treatment of active duodenal ulcer
  • Maintenance of healed duodenal ulcers
  • Short term treatment of active benign gastric ulcers
  • Short term treatment of active erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Pathological hypersecretory conditions including Zollinger- Ellison Syndrome
  • H. pylori eradication to reduce the risk of duodenal ulcer recurrence

Aslan is also used to associated treatment for these conditions: Gastro-esophageal Reflux Disease (GERD), Gastrointestinal Bleeding, Helicobacter Pylori Infection, Peptic Ulcer Disease, Hypersecretory conditions


Trade Name Aslan
Generic Lansoprazole
Lansoprazole Other Names Lansoprazol, Lansoprazole, Lansoprazolum
Weight 30mg, 15mg
Type Capsule
Formula C16H14F3N3O2S
Weight Average: 369.361
Monoisotopic: 369.075882012
Protein binding

97% of lansoprazole is plasma protein bound.

Therapeutic Class Proton Pump Inhibitor
Manufacturer Unimed Unihealth MFG, Ltd
Available Country Bangladesh
Last Updated: June 23, 2021 at 11:22 am


Lansoprazole Structure


Aslan dosage

Benign gastric ulcer: 30 mg daily in the morning for 8 weeks.

Duodenal ulcer: 30 mg daily in the morning for 4 weeks; maintenance 15 mg.

NSAID-associated duodenal or gastric ulcer: 15-30 mg daily for 4 weeks, followed by a further 4 weeks if not fully healed.

Zollinger-Ellison syndrome (and other hypersecretory conditions): Initially 60 mg once daily adjusted according to response; daily doses of 120 mg or more is given in two divided doses.

Gastroesophageal reflux disease: 30 mg daily in the morning for 4 weeks, followed by a further 4 weeks if not fully healed; maintenance 15-30 mg daily.

Acid-related dyspepsia: 15-30 mg daily in the morning for 2-4 weeks.

Side Effects

Severe or irreversible adverse effects: The possible induction of carcinoid tumors by profound acid suppression, and a rise in serum gastrin may occur. There is a rise in serum gastrin levels in the first 3 months of treatment, which are then maintained though at a lower level than those found in pernicious anaemia. Long term treatment with a proton pump inhibitor in patients with Helicobacter pylori infection may accelerate the development of atrophic gastritis.

Symptomatic adverse effect: Dose dependent diarrhoea occurs with an incidence of about 4% at 30 mg per day, rising to 8% at 60 mg per day. Headache occurs in 2-3% of treated patients


Gastric malignancy should be ruled out. Hepatic impairment. Pregnancy and lactation.


Aslan appears to be a selective inhibitor of the cytochrome P-450 monooxygenase system; there may be an effect on hepatic clearance, but there have been no reports to date of clinically relevant interactions. There is some uncertainty over the effect of Aslan on the oral combined contraceptive pill. Further assessment is currently underway. Physiological changes similar to those found with Omeprazole are likely to take place because of the reduction in gastric acid, which is likely to influence the bacterial colonization of the stomach and duodenum and also vitamin B12 absorption.

Food Interaction

  • Take before a meal. Take 30-60 minutes before meals.

Volume of Distribution

The apparent volume of distribution of lansoprazole is 0.4 L/kg.

Half Life

One source reports the half life of lansoprazole to be 0.9 - 1.6 hours, while another source cites 0.9 - 2.1 hours. The general consensus is that lansoprazole has a short half life and is approximately 2 hours or less. These numbers may be misleading since it suggests that lansoprazole has a short duration of action when in practice, lansoprazole can effectively inhibit acid secretion for ~24 hours due to it's mechanism of action.


The reported clearance of lansoprazole is 400-650 mL/min.

Pregnancy & Breastfeeding use

Aslan should be avoided in pregnancy unless there are compelling reasons.


Aslan is contraindicated in patients with known hypersensitivity to any component of the formulation.

Special Warning

Neonates:There is no relevant human data. The drug is not recommended for use with neonates.

Children: The youngest person to have received Aslan in clinical trials was 13 years old.

The Elderly: No problems have been encoun- tered in clinical use and there has been no increase in adverse drug reaction in the elderly.

Storage Condition

Store at 25° C.

Innovators Monograph

Aslan contains Lansoprazole see full prescribing information from innovator Monograph