Asidox inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It has bacteriostatic activity against a broad range of gm+ve and gm-ve bacteria.
Asidox has a very wide spectrum of activities and has been used in the treatment of a large number of infections caused by susceptible organisms.
Respiratory tract infections: Pneumonia, influenza, pharyngitis, tonsillitis, bronchitis, sinusitis, otitis media and other streptococcal and staphylococcal infections where tetracycline resistance is not a problem.
Genitourinary tract infections: Pyelonephritis, cystitis, urethritis, gonorrhea, epididymitis, syphilis, chancroid and granuloma inguinale.
Chlamydia: Lymphogranuloma venereum, psittacosis, trachoma.
Intestinal diseases: Whipples disease, tropical sprue, blind loop syndrome.
In acute intestinal amoebiasis: Asidox may be a useful adjunct to amoebicides.
Bacillary infections: Brucellosis, tularemia, cholera, travelers diarrhea
Acne: Acne vulgaris, acne conglobata and other forms of acne.
Other infections: Actinomycosis, yaws, relapsing fever, leptospirosis, typhus, rickettsial pox and Q fever, Cellulitis furunculosis, abscess and infections caused by Mycobacterium marinum, Bordetella pertussis and Bacillus anthracis.
Asidox is also used to associated treatment for these conditions: Acinetobacter infection, Acne Rosacea, Actinomycosis, Acute epididymo-orchitis caused by Chlamydia Trachomatis, Anal chlamydia infection, Bacterial Infection caused by Enterobacter aerogenes, Bartonellosis, Brucellosis, Campylobacter Infection, Chancroid, Chlamydial Urethritis, Chlamydial cervicitis, Cholera, Clostridium Infections, Epididymo-orchitis gonococcal, Gonorrhea, Granuloma Inguinale, Infection Due to Escherichia Coli, Intestinal Amebiasis, Listeria infection, Lymphogranuloma Venereum, Necrotizing ulcerative gingivostomatitis, Plague, Plasmodium Infections, Primary Syphilis, Psittacosis, Q Fever, Rectal infection, Rectal infection caused by Chlamydia Trachomatis, Recurring fever caused by Borrelia recurrentis, Relapsing fever caused by Borrelia recurrentis, Respiratory Tract Infections (RTI), Rickettsialpox, Rocky Mountain Spotted Fever, Secondary Syphilis, Severe Acne, Shigella Infection, Skin Infections, Tick-borne fever, Trachoma, Trachoma inclusion conjunctivitis, Tularemia, Typhus Fever, Upper Respiratory Tract Infection, Ureaplasma urethritis, Urinary Tract Infection, Yaws, Inhaled anthrax caused by Bacillus anthracis
|Other Names||Doxiciclina, Doxycyclin, Doxycycline, Doxycyclinum|
>90% , .
|Therapeutic Class||Tetracycline Group of drugs|
|Manufacturer||Asiatic Laboratories Ltd|
|Last Updated:||June 23, 2021 at 11:20 am|
Table Of contents
- 200 mg on day 1 as a single or in divided doses, followed by 100 mg once daily. Severe infections: Maintain initial dose throughout the course of treatment.
Relapsing fever and louse-borne typhus:
- 100 or 200 mg as a single dose.
Prophylaxis of scrub typhus:
- 200 mg as a single dose.
- 100 mg bid for 7 days or a single dose of 300 mg followed by a 2nd similar dose 1 hr later.
- 100-200 mg bid for at least 14 days.
- 50 mg daily for 6-12 wk.
Chloroquine resistant falciparum malaria acute attack:
- 200 mg daily for at least 7 days, w/ or after treatment w/ quinine.
Treatment and postexposure prophylaxis of inhalation anthrax:
- 100 mg bid, to complete a 60-day course after treatment w/ 1-2 other antibacterials.
Prophylaxis of chloroquine-resistant malaria:
- 100 mg daily for up to 2 yr.
- As 10% controlled-release subgingival preparation: Inject the contents of the syringe into the periodontal pocket, may be repeated 4 mth after initial treatment.
Susceptible infections: 200 mg on day 1 followed by 100-200 mg daily depending on the severity of infection.
Gastrointestinal disterbances,eg. anorexia, vomiting, dysentry etc. overgrowth of resistant organisms may cause Glossitis, Stomatitis, or Staphylococcal enterocolitis; Apart from these skin rashes, purpura may occur. Photosensitivity and dermatological reactions are rare.
During development of teeth (last trimester of pregnency, upto 12 yrs of age) the use of tetracyclines may lead to discoloration of teeth. So tetracyclines should not be administered during these periods
Should not be taken with antacids, milk, other alkalis e.g. calcium, magnesium and iron, penicillin, anticoagulants, anti-diabetic agents, anticonvulsants and enzyme inducing drugs.
- Avoid alcohol.
- Avoid multivalent ions. Calcium, iron, and aluminum containing products taken up to 2 hours before and 6 hours after administration can decrease drug concentrations.
- Take with a full glass of water.
Volume of Distribution
Asidox diffuses readily into most body tissues, fluid and/or cavities and the volume of distribution has been measured as 0.7 L/kg .
16.33 hr (± 4.53 sd) .
The excretion of doxycycline by the kidney is about 40% over 72 hours in individuals with normal kidney function (creatinine clearance approximately 75 mL/min). This rate may fall as low as 1-5% over 72 hours in individuals with severe renal insufficiency (creatinine clearance below 10 mL/min). Some clinical studies have shown no major difference in serum half-life of doxycycline (range 18-22 hours) in patients with normal and severely impaired renal function. Hemodialysis does not affect serum half-life of doxycycline .
Pregnancy & Breastfeeding use
Pregnancy: Asidox should be avoided in pregnant women, because of the risk of both staining and effect on bone growth in the fetus.
Lactation: Asidoxs enter breast milk, and mothers taking these drugs should not breastfeed their child.
Hypersensitivity to doxycycline and any of the tetracyclines. Concurrent use with methoxyflurane. Lactation
Neonates and children: Asidox may cause permanent discoloration of the teeth and so is contraindicated for neonates and children under 12 years.
Elderly: No special precautions are necessary in the elderly.
It should be stored in a dry place at room temperature.