Aqualax Powder For Solution, Oral Capsule, Oral Liquid, Oral Syrup, Oral Tablet, Rectal Enema, Oral/rectal
The primary mode of action is thought to be through the osmotic effect of polyethylene glycol 3350 which causes water to be retained in the colon and produces a watery stool. Aqualax induces as diarrhea which rapidly cleanses the bowel, usually within four hours.
This is white powder for reconstitution. It is a synthetic polyglycol having an average molecular weight of 3350. Aqualax is an osmotic agent that causes water to be retained with the stool. Aqualax appears to have no effect on the active absorption or secretion of glucose or electrolytes.
Aqualax is used for the treatment of constipation. This should be used for 2 weeks or less or as directed by physician. Aqualax 3350 is a prescription only laxative that has been prescribed by physician to treat constipation. This product should only be used by the person for whom it is prescribed.
Aqualax is also used to associated treatment for these conditions: Chronic Constipation, Constipation, Dry Eye Syndrome (DES), Dry Eyes, Occasional Constipation, Bowel preparation therapy, Eye lubrication
|Polyethylene Glycol Other Names||Macrogol, Macrogol 3350, Macrogol 4000, Macrogol 6000, PEG, Polyethylene glycol 3350, Polyethylene glycol 4000, Polyethylene glycol 6000|
|Type||Powder For Solution, Oral Capsule, Oral Liquid, Oral Syrup, Oral Tablet, Rectal Enema, Oral/rectal|
There is limited information on the protein binding profile of polyethylene glycols.
|Therapeutic Class||Osmotic purgatives|
|Manufacturer||Incepta Pharmaceuticals Limited|
|Available Country||Bangladesh, United States|
|Last Updated:||June 23, 2021 at 11:24 am|
The usual dose of Aqualax is 17 gm of powder per day (or as directed by physician) in a glass of water, juice, coke, coffee or tea. Each bottle of Aqualax is supplied with a cup that is used to measure 17 gm or 8.5 gm of laxative powder when filled upto the marked line.
It should always be taken by mouth. Measure the dose using the supplied cup, stir and dissolve in a glass of water, juice, coke, coffee or tea. Taking more than the prescribed dose may cause loss of fluid due to severe diarrhea.
Duration of Treatment
Aqualax achieves its best results when used between one and two weeks. It may be discontinued after several satisfactory bowel movements. Should unusual cramps, bloating, or diarrhea occur, consultation with physician is needed. Aqualax is intended for up to a two-week course of therapy. It should not be used for a longer time unless directed by a physician. After successfully completing the Aqualax therapy (usually between one and two weeks) discussion with a physician is needed to change lifestyle that may produce more regular bowel habits (adequate dietary and fluid intake, regular exercise).
Nausea, abdominal bloating, cramping and flatulence may occur. High doses may produce diarrhea and excessive stool frequency, particularly in elderly nursing home patients. Patients taking other medications containing polyethylene glycol have occasionally developed urticaria suggestive of an allergic reaction.
Patients with symptoms suggestive of bowel obstruction (nausea, vomiting, abdominal pain or distention) should be evaluated to rule out this condition before initiating Aqualax therapy. Aqualax should be administered after being dissolved in water, juice, coke, coffee or tea.
No specific drug interactions have been demonstrated.
- Avoid alcohol. Withdrawing from alcohol increases the risk of seizures, which is also caused by the drug.
- Avoid milk and dairy products.
- Avoid solid foods. Consume only clear liquids from the start of drug treatment until after the colonoscopy.
Volume of Distribution
Following a two-day split-dosing regimen of an oral suspension containing 140 grams of PEG 3350 in healthy subjects, the mean volume of distribution was 48,481 L.
Following a two-day split-dosing regimen of an oral suspension containing 140 grams of PEG 3350 in healthy subjects, the mean half life was 4.1 hours.
There is limited information on the clearance rate of polyethylene glycols.
Pregnancy & Breastfeeding use
Pregnancy: It is not known whether Polyethylene glycol can cause fetal harm when administered to a pregnant woman, or can effect reproductive capacity. Polyethylene glycol should only be administered to a pregnant woman if clearly needed.
Lactation: There is no information on the use of Polyethylene glycol while nursing. Consultation with a physician is necessary in case of breastfeeding.
Polyethylene glycol is contraindicated in patients with known or suspected bowel obstruction and patients known to be allergic to polyethylene glycol.
There have been no reports of accidental overdosage. In the event of overdosage diarrhea would be the expected major event. If an overdose of drug occurred without concomitant ingestion of fluid, dehydration due to diarrhea may result. Medication should be terminated and free water administered.