Apocal Tablet, Chewable Tablet

Calcium carbonate reacts with gastric acid to produce a salt and water. For calcium carbonate the postulated chemical reaction is:

CaCO3 + 2HCl = CaCl2 + H2O + CO2

Indicated in raised calcium requirement e.g. during pregnancy and lactation, and in children and adolescents at time of rapid growth, inadequate intake of calcium in the diet due to malnutrition, prevention and treatment of osteoporosis, disorders of osteogenesis and tooth formation, latent tetany.


Adult: One Apocal 500 tablet or as directed by the physician. For the prevention of osteoporosis, 1-3 Apocal 500 tablet is recommended generally as a dietary supplement . Doses for children is half of those for adults. A large dose should not be taken without physician\'s advice.

Adolescent: One to two Apocal tablet daily.

Children: One Apocal tablet daily.

Apocal is also used to associated treatment for these conditions: Acid Reflux, Acid indigestion, Bloating, Calcium Deficiency, Calcium Metabolism Disorders, Calcium and Vitamin D Deficiencies, Colic, Dyspepsia, Gastric Ulcer, Gastroesophageal Reflux, Heartburn, Hemorrhoids, Hot Flushes, Hyperacidity, Hyperphosphataemia, Hypovitaminosis D, Low Bone Density, Osteodystrophy, Osteomalacia, Osteoporosis, Postmenopausal Osteoporosis, Postoperative Gas, Proctitis, Vertebral Fractures, Calcium loss, Gastrointestinal ulceration, Dietary supplementation

Trade Name Apocal
Generic Calcium Carbonate
Other Names Calcio carbonato, Calcium carbonate, Calcium carbonate (1:1), Calciumcarbonat, Carbonate de calcium, Carbonato de calcio, Kalziumkarbonat, Kohlensaurer kalk, Precipitated calcium carbonate
Weight 500mg, 250mg
Type Tablet, Chewable Tablet
Formula CCaO3
Weight Average: 100.087
Monoisotopic: 99.947335021
Protein binding

Calcium acts as a co-factor to numerous enzymes.

Therapeutic Class Minerals in bone formation, Specific mineral preparations
Manufacturer Apex Pharmaceuticals Ltd
Available Country Bangladesh
Last Updated: June 23, 2021 at 11:17 am


Apocal dosage

Apocal is always used orally and when used as an antacid the recommended doses for adults are equivalent to 540-2000 mg Apocal per day, doses for children being half of those for adults. As a dietary supplement, such as for the prevention of osteoporosis, 1250-3750 mg Apocal (500-1500 mg calcium) daily is recommended in general, but again this will need to be tailored to the individual patient depending on any specific disease such as Calcium deficiency, malabsorption or parathyroid function. In pregnancy and lactation the recommended daily dose of calcium is 1200-1500 mg. In chronic renal failure the doses used vary from 2.5 - 9.0 gm Apocal per day and need to be adjusted according to the individual patient. To maximize effective phosphate binding in this context the Apocal should be given with meals.

Side Effects

In rare cases, flatulence, diarrhoea or constipation.


In the presence of mild hypercalciuria, excretion levels must be carefully monitored and where necessary the dose of calcium carbonate should be reduced or treatment should be stopped. Patients with a history of stone formation should also be recommended to increase their fluid intake. High dosage of vitamin D should be avoided during Calcium therapy unless specifically indicated.


Oral calcium can reduce internal absorption of tetracycline and fluoride prepa-rations and an interval of at least 3 hours should therefore be allowed between ingestion of these medications. Vitamin D increases internal absorption of calcium. The intestinal uptake of calcium may be reduced by concomitant ingestion of certain foods (e.g. spinach, milk and milk products).

Food Interaction

  • Take with or without food. Food increases the absorption of calcium carbonate, which may be advantageous in its use as a calcium supplement.

Volume of Distribution

Calcium is rapidly distributed taken up by skeletal tissues following absorption and distribution into extracellular fluids. Bone contains 99% of the body's calcium and the remaining 1% is approximately equally distributed between intracellular and extracellular fluids.

Pregnancy & Breastfeeding use

Pregnant women : Calcium containing drugs are used widely in pregnancy by way of calcium supplement or antacid therapy. No relationship between malformation in general and calcium exposure has been noted.

Lactating mother : There is no contraindication to the use of calcium carbonate in lactating mother.


Hypersensitivity to the Apocal or any inactive ingredient of the medication. Hypercalcemia (e.g. in hyperparathyroidism, overdosage of vitamin D, demineralizing tumours such as plasmacytomas and bone metastases), severe hypercalcuria, several renal insufficiency.

Special Warning

USE IN CHILDREN: Calcium carbonate has been extensively studied in children and infants with chronic renal failure and is both safe and effective.

USE IN ELDERLY: In case of elderly patients with renal failure when calcium carbonate is taken constipation may be troublesome one for this group. For this reason, monitoring of serum calcium and phosphate is of course indicated for elderly patients.

Storage Condition

Store in a cool, dry place in controlled room temperature.

Apocal contains Calcium Carbonate see full prescribing information from innovator Monograph