Ansulin N Sc Injection

Insulin Human (rDNA) is human insulin made by recombinant DNA technology. It has the same structure and function as natural insulin. Insulin regulates the glucose metabolism and stimulates the ingestion and utilization of glucose by liver, muscle and fat tissue. It also lowers blood glucose by accelerating glycogenesis and inhibiting gluconeogenesis. 

Insulin Human (rDNA) R starts action within 30 minutes after injection, reaches its peak within 1.5-3.5 hours and lasts about 7-8 hours. Insulin Human (rDNA) N starts action within 1.5 hours after injection, reaches its peak within 4-12 hours & lasts about 24 hours.


Treatment of all patients with type 1 diabetes. Treatment of patients with type 2 diabetes who are not adequately controlled by diet and/ or oral hypoglycemic agents.

For the initial stabilization of diabetes in patients with diabetic ketoacidosis, hyperosmolar non-ketotic syndrome and during periods of stress such as severe infections and major surgery in diabetic patients. Treatment of gestational diabetes.

Ansulin N is also used to associated treatment for these conditions: Diabetes Mellitus, Type 1 Diabetes Mellitus

Trade Name Ansulin N
Generic Insulin human
Other Names High molecular weight insulin human, Human insulin, Insulin (human), Insulin human, Insulin Human Regular, Insulin recombinant human, Insulin recombinant purified human, Insulin regular, Insulin, human, Insulina regular, Neutral insulin, Regular Insulin, human, Soluble insulin
Weight 40iu/ml, 100iu/ml
Type Sc Injection
Formula C257H383N65O77S6
Weight 5808.0 Da
Therapeutic Class Medium Acting Insulin
Manufacturer Square Pharmaceuticals Ltd
Available Country Bangladesh
Last Updated: June 23, 2021 at 11:21 am


Ansulin N dosage

The average range of total daily insulin requirement for maintenance therapy in type 1 diabetic patients lies between 0.5 and 1.0 IU/kg. In pre-pubertal children it usually varies from 0.7 to 1.0 IU/kg, whereas in insulin resistant cases, e.g. during puberty or due to obesity, the daily insulin requirement may be substantially higher. Initial dosages for type 2 diabetic patients are often lower, e.g. 0.3 to 0.6 IU/kg/day.

The dosage form, the dosage and the administration time of the insulin are different due to the individual differences of each patient. In addition, the dosage is also affected by food, working style and exercising intensity. Therefore, patients should use the insulin under doctor's instruction.

An injection should be followed by a meal or snack containing carbohydrates within 30 minutes. Injection is administered subcutaneously in the upper arm, thigh, buttock or abdominal wall. A subcutaneous injection into the abdominal wall results in a faster absorption than from other injection sites. Insulin Human (rDNA) R can be given intravenously only by the physician in emergency situations. However, Insulin Human (rDNA) N, is never to be administered intravenously.Preparation before use:

  • Clean your hands.
  • Shake or rotate the vial gently to mix the solution uniformly and check if the insulin has the normal appearance.
  • In case of using a new vial, flip off the plastic protective cap and wipe the rubber plug with an alcohol swab.
  • Draw air into your syringe equal to the amount of insulin needed.
  • Puncture the needle into the vial and inject the air.
  • Turn the bottle and syringe upside down and withdraw correct dose of insulin into the syringe.
  • Before pulling out the needle, check if there are any bubbles remain in the syringe. If so, put the syringe upright and tap the syringe to discharge the air bubbles.

Injection site:

  • Choose the area where skin is less tight, such as the upper arm, thigh, buttock or abdomen.
  • To avoid tissue damage, choose a site for each injection that is at least 1 cm from the previous injection site.

Injection method:

  • Cleanse the skin with alcohol where the injection is to be made.
  • Put the needle in such a position as to form 45° angle with the skin.
  • Puncture the needle into skin and inject insulin.
  • Keep the needle under the skin for at least 6 seconds to make sure the entire dose is injected.
  • Pull the needle out and apply gentle pressure over the injected site for several seconds.
  • Do not rub the injection site.

Side Effects

Hypoglycemia is the most common adverse effect during insulin treatment and symptoms of hypoglycemia may occur suddenly. Few cases of the allergic reaction such as red and swollen or itching are reported. It usually disappears in a few days. In some instances, the allergy may be caused by other reasons rather than insulin, such as disinfectant and poor injection technique.


Inadequate dosing or discontinuation especially in type 1 diabetes, may lead to hyperglycemia. Hypoglycemia may occur if the insulin dose is too high in relation to the insulin requirement. Omission of a meal or unplanned, strenuous physical exercise may lead to hypoglycemia.


When using oral contraceptive drug, adrenal cortical hormone, thyroid hormone, etc., the drugs that can result in the rise of blood glucose; you might need to increase the amount of Insulin. When using drugs with hypoglycemic activities, salicylate, sulfanilamide and other anti-depressants, which will result in the decrease of blood glucose, the dosage of insulin should be reduced.

Food Interaction

  • Avoid alcohol. Alcohol may impair blood glucose control.

Half Life

Systemic insulin disposition (apparent terminal half-life) following oral inhalation of 4 to 48 units of human insulin was 120-206 minutes.

Pregnancy & Breastfeeding use

There are no restrictions on treatment of diabetes with insulin during pregnancy, as insulin does not pass the placental barrier. Insulin treatment of the nursing mother presents no risk to the baby.


Hypoglycemia or the patients who have allergic reaction to insulin or any of the excipients.

Acute Overdose

Excessive use of insulin may lead to hypoglycemia during the treatment. Slight to moderate hypoglycemia may suddenly occur. It is important to get immediate treatment when hypoglycemia occurs. If you have frequent hypoglycemia, you should consult your doctor to discuss possible changes in therapy, diet plans, and/or exercise programs to help you avoid hypoglycemia.

Storage Condition

Store at 2°C - 8°C in a refrigerator. Do not freeze. In case of insulin for recent use need not be refrigerated, try to keep it in a cool place and keep away from heat and light. The insulin in use can be kept under the room temperature for a month.

Ansulin N contains Insulin human see full prescribing information from innovator Monograph