Anquil Tablet, Im/iv Injection
Anquil is a triazolo analogue of the 1,4-benzodiazepine class of drugs. It is an anxiolytic with hypnotic and anticonvulsive properties. Anquil is presumed to produce its effects via interacting with the Gamma Aminobutyric Acid (GABA) - benzodiazepine receptor complex. Like all benzodiazepines, it causes a dose related CNS depressant activity varying from mild impairment of task performance to hypnosis.
- * Anxiety disorder
- * Short term relief of anxiety
- * Anxiety associated with depression
- * Panic disorder, with or without agoraphobia.
Anquil is also used to associated treatment for these conditions: Anxiety, Generalized Anxiety Disorder (GAD), Panic Disorder
|Weight||7.5mg, 15mg, 15mg/3ml,|
|Type||Tablet, Im/iv Injection|
Alprazolam is 80% protein bound in serum. The majority of this protein binding is to serum albumin. Alprazolam is also bound to alpha1-acid glycoprotein with low frequency.
|Therapeutic Class||Benzodiazepine sedatives|
|Manufacturer||Brussels Laboratories Pvt Ltd, General Pharmaceuticals Ltd, Neon Healthcare Ltd|
|Available Country||India, Bangladesh, United Kingdom,|
|Last Updated:||June 23, 2021 at 9:00 am|
Table Of contents
Treatment should be initiated with a dose of 0.25 to 0.5 mg three times daily. Depending on the response, dose may
be increased at intervals of 3 to 4 days in increments of no more than 1 mg per day. The maximum dose should not
exceed 4 mg/day. Occasional patients with panic disorder may need as much as 10 mg a day to achieve a
successful response and in these cases periodic reassessment and consideration of dosage adjustment is required.
Dosage should be individualized for maximum beneficial effect with a lowest possible dose. If side-effects occur at
starting dose, dose may be lowered. When discontinuing therapy, dosage should be reduced gradually by no more
than 0.5 mg every three days.
In elderly patients or in patients with advanced liver disease, the usual starting dose is 0.25 mg, two or three times
daily and may be gradually increased if needed and tolerated. Safety and effectiveness of Anquil in individuals
below 18 years of age have not been established.
Anquil XR 1 should be administered once daily, preferably in the morning by patients who are on multiple dosage
regimen of Anquil 0.25/0.5 mg. The tablets should be taken intact, they should not be chewed, crushed, or broken.
Side effects, if occur, are generally observed at the beginning of therapy and usually disappear upon continued medication. The most frequent side effects are drowsiness and light headedness. The other side effects, that may occur include depression, headache, confusion, dry mouth, constipation etc.
Because Anquil may produce psychological and physical dependence, increment of dose or abrupt discontinuation of Anquil therapy should not be done without physician's advice. Duration of therapy must be determined by the physicians. Anquil should be administered with caution to patients with hepatic or renal disease, chronic pulmonary insufficiency or sleep apnea.
Anquil produces additive CNS depressant effects when co-administered with other psychotropic medications, anticonvulsants, antihistaminics, ethanol and other drugs which themselves produce CNS depression.
- Avoid alcohol. Alcohol may potentiate the CNS depressant effects of this drug.
- Avoid grapefruit products.
- Limit caffeine intake.
- Take with or without food. Food increases the Cmax of extended release alprazolam by 25%, but the AUC and half life are not affected.
Volume of Distribution
Volume of distribution following oral administration is 0.8-1.3L/kg. Anquil crosses the blood-brain barrier.
11.2 hours in healthy patients. The half life is 16.3h in the elderly, 5.8-65.3h in patients with alcoholic liver disease, 9.9-40.4h in obese patients. The half life is 25% higher in Asian patients compared to Caucasians. Other studies have shown the half life to be 9-16h.
Oral clearance is 0.90±0.21mL/min/kg but this increases to 2.13±0.54mL/min/kg when given with CYP3A inducers. Other studies have demonstrated a clearance of 0.70-1.5mL/min/kg.
Pregnancy & Breastfeeding use
Pregnancy: Anquil has been categorized in pregnancy category D; that means, it should be avoided in pregnancy.
Lactation: Like other benzodiazepines, Anquil is assumed to be excreted in breast milk. Therefore, nursing should not be undertaken by mothers who must use Anquil.
Contraindicated in patients with hypersensitivity to alprazolam or other benzodiazepines. Anquil is also contraindicated in patients with myasthenia gravis, acute narrow angle glaucoma, during pregnancy and also in infants.
Use in Children: Safety and efficacy of Anquil in patients under the age of 18 years has not been established.
Manifestations of Anquil over dosage include somnolence, confusion, impaired coordination, diminished reflexes and coma. In such cases of over dosage general supportive measures should be employed along with immediate gastric lavage.
Interaction with other Medicine
The CNS-depressant action of Anquil may be aggravated by concomitant use of other psychotropic drugs, anticonvulsants, antihistaminics, alcohol and oral contraceptives.
Anquil tablets should be stored in a cool and dry place, protected from light and moisture.