Angirid MR Tablet (Modified Release)

Trimetazidine is an anti-ischemic (anti-anginal) metabolic agent, which improves myocardial glucose utilization through inhibition of long-chain 3-ketoacyl CoA thiolase activity, which results in a reduction in fatty acid oxidation and a stimulation of glucose oxidation. High fatty acid oxidation rates are detrimental during ischemia due to an inhibition of glucose oxidation leading to uncoupling of glycolysis and an increase in proton production, which has the potential to accelerate sodium and calcium overload in the heart. This leads to an exacerbation of ischemic injury and decreased cardiac efficiency during reperfusion.

Uses

Long-term treatment of Ischaemic heart disease (angina pectoris, sequelae of infarction).

Trade Name Angirid MR
Generic Trimetazidine Dihydrochloride
Weight 35mg
Type Tablet (Modified Release)
Therapeutic Class Other Anti-anginal & Anti-ischaemic drugs
Manufacturer Acme Laboratories Limited
Available Country Bangladesh
Last Updated: June 23, 2021 at 11:26 am

Dosage

Angirid MR dosage

One 20 mg tablet thrice daily after meals. No dosage adjustments are required in patients with impaired renal and hepatic function.

One 35 mg modified release tablet twice daily at mealtimes in the morning and evening.

Side Effects

Trimetazidine is safe and well tolerated. The most commonly encountered side effects are gastric discomfort, nausea, headache and vertigo. However, the side effects are mild and non-specific.

Interaction

No drug interactions have so far been reported. In particular, no interactions of Trimetazidine with beta-blockers, calcium antagonists, nitrates, heparin, hypolipidemic agents or digitalis have been reported.

Pregnancy & Breastfeeding use

Pregnancy: Studies in animals have not demonstrated a teratogenic effect. However, in the absence of clinical data and for safety reasons, prescription should be avoided during pregnancy.

Nursing Mothers: There is no information on the secretion of Trimetazidine into breast milk. However, breast feeding should be discontinued if the use of Trimetazidine is considered essential.

Contraindication

Hypersensitivity to Angirid MR.

Storage Condition

Store in a cool and dry place, protect from light and moisture. Keep out of the reach of children.

Angirid MR contains Trimetazidine Dihydrochloride see full prescribing information from innovator Monograph

FAQ

Is Angirid MR a muscle relaxer or painkiller?

Angirid MR is a narcotic-like pain reliever. Angirid MR is used to treat moderate to severe pain in adults. The extended-release form of Angirid MR is for around-the-clock treatment of pain.

What is the Angirid MR used for?

Angirid MR is used to relieve moderate to moderately severe pain. Angirid MR extended-release tablets and capsules are only used by people who are expected to need medication to relieve pain around-the-clock. Angirid MR is in a class of medications called opiate (narcotic) analgesics.

Does Angirid MR make me sleepy?

Angirid MR oral tablet may cause drowsiness. You should not drive, use heavy machinery, or perform any dangerous activities until you know how this drug affects you. Angirid MR may also cause other side effects.

Can I take Angirid MR and ibuprofen together?

It's safe to take Angirid MR with paracetamol, ibuprofen or aspirin (aspirin is suitable for most people aged 16 years and over). Do not take Angirid MR with codeine-containing painkillers you can buy from a pharmacy. You'll be more likely to get side effects.

Is Angirid MR stronger than hydrocodone?

Studies show that Angirid MR and hydrocodone are both comparatively effective for pain. Some reports show that Angirid MR has milder side effects compared to hydrocodone. However, other studies show that hydrocodone is more potent and produces more pain relief in some people.

Can I drive after take Angirid MR?

Angirid MR oral tablet may cause drowsiness. You should not drive, use heavy machinery, or perform any dangerous activities until you know how this drug affects you. Angirid MR may also cause other side effects.

What are the side effects of Angirid MR?

Side effects associated with use of Angirid MR, include the following:

  • constipation
  • nausea
  • dizziness
  • vertigo
  • headache
  • drowsiness
  • vomiting
  • agitation
  • anxiety
  • mood swings
  • euphoria
  • hallucinations
  • nervousness
  • muscle spasms or stiffness
  • indigestion
  • weakness
  • itching
  • diarrhea
  • dry mouth
  • sweating
  • feeling unwell (malaise)
  • menopausal symptoms
  • rash
  • urinary frequency
  • urinary retention
  • dilation of blood vessels (vasodilation)
  • visual disturbances
  • abnormal gait
  • amnesia
  • cognitive dysfunction
  • depression
  • difficulty in concentration
  • feeling uneasy
  • painful urination
  • fatigue
  • menstrual dysphoric disorder
  • motor system weakness
  • lightheadedness upon standing (orthostatic hypotension)
  • numbness and tingling
  • seizures
  • suicidal tendencies
  • fainting (syncope)
  • fast heart rate
  • tremors
  • abnormal electrocardiogram (ECG)
  • swelling (angioedema)
  • cough
  • flushing
  • high blood pressure (hypertension)
  • low blood pressure (hypotension), may be severe
  • reduced blood flow to the heart (myocardial ischemia)
  • palpitations
  • hives
  • withdrawal syndrome
  • life threatening respiratory depression
  • neonatal opioid withdrawal syndrome
  • adrenal insufficiency
  • abdominal pain
  • serotonin syndrome
  • severe allergic reaction (anaphylaxis)
  • androgen deficiency

Can I take 2 50mg Angirid MR?

If you take two single doses of Angirid MR 50 mg capsules at once by mistake, this will generally not be harmful. If pain returns, continue taking Angirid MR 50 mg Capsules as usual. If high doses are taken accidentally (e.g. a dose of more than two Angirid MR 50 mg Capsules at once), a number of symptoms may occur.

What drugs should not be taken with Angirid MR?

Do not use this medicine if you are using or have used an MAO inhibitor (MAOI) such as isocarboxazid, linezolid, phenelzine, selegiline, tranylcypromine) within the past 14 days. You should not take other medicines that also contain Angirid MR.

Can I take Angirid MR at night?

Angirid MR should be started at a low dose and raise the dose slowly toward the maximum dose. Start with one tablet at bedtime. After 3 - 7 days, increase to one tablet twice daily (morning and bedtime). After an additional 3 - 7 days, increase to one tablet three times per day (morning, noon, and bedtime).

Does Angirid MR help me relax?

In general, Angirid MR can cause a high that makes people feel relaxed, elevates moods, dulls pain, and reduces anxiety when it is used for nonmedical purposes.

Does tramadol make me last longer in bed?

Angirid MR is an effective treatment for PE, resulting in a significant prolongation of IELT that showed clinical improvements in satisfaction with sexual intercourse and control over ejaculation, and decreases in ejaculation-related personal distress and interpersonal difficulty.

Does Angirid MR cause depression?

More severe symptoms of Angirid MR abuse typically occur when higher doses of the drug are taken or when Angirid MR is taken in combination with another substance. Severe symptoms of tramadol abuse can include seizures and central nervous system depression.

Does Angirid MR help with arthritis pain?

Angirid MR may be used for short periods of time to help treat pain associated with inflammatory arthritis.

Does Angirid MR help with inflammation?

The analgesic drug Angirid MR has been shown to relieve pain in inflammatory conditions, to inhibit the development of experimental inflammation, and to reduce prostaglandin (PG)E(2)concentrations in the inflammatory exudate.

Can I take Angirid MR (tramadol) and tylenol at the same time?

Angirid MR and acetaminophen combination is used to relieve acute pain severe enough to require an opioid treatment and when other pain medicines did not work well enough or cannot be tolerated. When used together, the combination provides better pain relief than either medicine used alone.

Is Angirid MR good for back pain?

Patients who tolerated it well, Angirid MR was effective for the treatment of chronic low back pain.

How much Angirid MR can I take?

Adults and children 16 years of age and older—At first, 50 to 100 milligrams (mg) every 4 to 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 400 mg per day.

How strong is Angirid MR?

Angirid MR is available in a variety of forms, including: immediate release tablets, in 50 milligram (mg) strengths. extended-release tablets and capsules, available in 100 mg, 150 mg, 200 mg, and 300 mg strengths.

What happens if I take Angirid MR for a long time?

When Angirid MR is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain.

Is Angirid MR safe for kidney?

Angirid MR is generally preferred for moderate pain in CKD patients because it is not known to be directly nephrotoxic. Nonetheless, it must be noted that its systemic elimination is reduced with advanced CKD (GFR <30 ml/min/1.73 m2).

Can Angirid MR make me aggressive?

Patients during Angirid MR dependence period were angry, hostile, and aggressive. On the other hand, after treatment the main problem observed was the significant increase in comorbid anxiety, depressive, and obsessive-compulsive symptoms, but no increase was found in psychotic symptoms.

Is Angirid MR a antidepressant?

Angirid MR is a powerful analgesic medication with antidepressant effects like venlafaxine.

Is there serotonin in Angirid MR?

Angirid MR is widely prescribed for treating acute and chronic forms of pain. It is a weak mu-receptor opioid agonist and also increases concentrations of serotonin and noradrenaline within the limbic system of the brain. The therapeutic range of Angirid MR is relatively wide.

How much Angirid MR can I take for toothache?

Adults 2 tablets every 4 to 6 hours as needed for up to 5 days. Do not take more than 8 tablets per day.

What is the antidote for Angirid MR?

Diazepam/naloxone combination is the most efficient antidote to reverse Angirid MR-induced CNS toxicity in the rat.

What does Angirid MR do to my brain?

Angirid MR works by changing how your brain senses pain. Angirid MR is similar to substances in your brain called endorphins. Endorphins bind to receptors (parts of cells that receive a certain substance). The receptors then decrease the pain messages that your body sends to your brain.

What does Angirid MR do to the body?

Angirid MR is used to help relieve moderate to moderately severe pain. Angirid MR is similar to opioid analgesics. It works in the brain to change how your body feels and responds to pain.

How long does take Angirid MR to work?

Angirid MR start to work within 30 to 60 minutes. It used for pain that is expected to last for only a short time. You may be told to take fast-acting Angirid MR only when you need it for pain or on a regular basis.

Does Angirid MR cause insomnia?

A single dose of Angirid MR 50 mg disturbs sleep in the night of drug application. With 100 mg, sleep is disturbed in both the night of drug application and in the subsequent night.

Does Angirid MR need to be tapered off?

It is best to taper off the drug over time in order to minimize negative withdrawal symptoms. Tapering off Angirid MR involves slowly reducing the dosage over time. Common tramadol withdrawal symptoms include:

  • Agitation
  • Anxiety
  • Depression
  • Cravings
  • Nausea and vomiting
  • Headaches
  • Confusion
  • Restlessness
  • Loss of appetite
  • Sweating
  • Muscle pain
  • Blurred vision
  • Insomnia
  • Mood swings
  • Irritability
  • Tingling sensations
  • Diarrhea
  • Nightmares
  • Dizziness
  • Abdominal cramps
  • Tremors

Will Angirid MR help a tooth ache?

Angirid MR has limited indication for management of acute pain in dentistry, possibly as an alternative analgesic when gastrointestinal side effects contraindicate the use of nonsteroidal anti-inflammatory drugs and when codeine/acetaminophen combination analgesics are not well-tolerated or are contraindicated.