Amoctin

Amoctin Tablet

Amoctin is a benzodiazepine with a pronounced sleep-inducing activity. It depresses the reticular-activating system in the brainstem by enhancing the inhibitory effect of GABA on brain cells, thus preventing excessive brain activity.

Uses

Short-term management of insomnia, Infantile spasms

Amoctin is also used to associated treatment for these conditions: Insomnia, Myoclonic seizures

Amoctin

Trade Name Amoctin
Generic Nitrazepam
Nitrazepam Other Names N-desmethylnimetazepam, Nitrazepam, Nitrazépam, Nitrazepamum
Weight 5mg
Type Tablet
Formula C15H11N3O3
Weight Average: 281.2661
Monoisotopic: 281.080041233
Therapeutic Class Benzodiazepine hypnotics
Manufacturer Skylab Pharmaceuticals Ltd
Available Country Bangladesh
Last Updated: June 23, 2021 at 11:23 am

Structure

Amoctin
Nitrazepam Structure

Dosage

Amoctin dosage

Short-term management of insomnia:

  • Adult: 5 mg at night; increase to 10 mg if necessary.
  • Elderly: and debilitated patients: ≤normal adult dose.

Infantile spasms:

  • Child: Infants: 125 mcg/kg bid; gradually increase to 250-500 mcg/kg bid.

May be taken with or without food

Side Effects

Hypotension, palpitation; agitation, aggressiveness, amnesia, ataxia, confusion, delusions, disorientation, dizziness, fatigue, hallucination, hangover, headache, irritability, nightmares, psychoses, rage, restlessness, sedation; rash; changes in libido; constipation, diarrhoea, excessive salivation, heartburn, nausea, vomiting; granulocytopenia, leukopenia; falling, muscle weakness; blurred or double vision; tinnitus (associated with withdrawal); aspiration, increased bronchial secretion, dyspnoea.

Precaution

May induce anterograde amnesia; caution patients to have uninterrupted sleep of 7-8 hr after ingestion of dose. May impair ability to drive or operate machinery. Depression, especially if suicidal risk may be present. History of drug abuse or acute alcoholism. Hepatic and renal impairment. Respiratory disease. Debilitated patients. Patients who are at risk of falls. Children, elderly. Pregnancy and lactation.

Interaction

CNS depressant effect increased with alcohol, barbiturates, TCAs, phenothiazines, morphine derivatives. Effects may be antagonised by theophylline. Increased levels/effects with probenecid. Reduced levels/effects with rifampicin. May reduce effects of levodopa.

Food Interaction

  • Avoid alcohol.
  • Limit caffeine intake.
  • Take with food.

Half Life

15-38 hours (mean elimination half life 26 hours).

Pregnancy & Breastfeeding use

Category not classified

Contraindication

Myasthenia gravis, narrow-angle glaucoma, severe respiratory insufficiency, sleep apnoea syndrome, severe hepatic impairment, porphyria.

Acute Overdose

Symptoms: Somnolence, drowsiness, confusion, ataxia, impaired reflexes, coma, dyspnoea, hypotension, respiratory and cardiovascular depression. 

Management: Supportive. Gastric lavage may be beneficial if performed soon after ingestion. Flumazenil may reverse benzodiazepine-induced CNS depression.

Storage Condition

Store at room temperature. Protect from light and moisture.