Aminouracil Mustard
Aminouracil Mustard Uses, Dosage, Side Effects, Food Interaction and all others data.
Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage.
Uracil Mustard selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Uracil Mustard-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
| Trade Name | Aminouracil Mustard |
| Generic | Uracil mustard |
| Uracil mustard Other Names | 5-aminouracil mustard, Aminouracil mustard, Uracil mustard, Uracil nitrogen mustard, Uramustina, Uramustine, Uramustinum |
| Type | |
| Formula | C8H11Cl2N3O2 |
| Weight | Average: 252.098 Monoisotopic: 251.022832025 |
| Protein binding | 5% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Used for its antineoplastic properties.
How Aminouracil Mustard works
After activation, it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.
Innovators Monograph
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