Aminosol Iv Infusion, Ampule

Amino Acids is a sterile aqueous solution, consisting of crystalline amino acids and D-sorbitol with electrolytes. Amino Acids is necessary as the nitrogen sources for parenteral nutrition in which nitrogen is provided in the form of essential and non-essential amino acids. The solution is clear, colorless having a pH lying in the range of 5.7 to 7.0.

Composition

Each 100 ml contains:

i) Active ingredients Specification Quantity

L-Isoleucine USP 0.352 gm

L-Leucine USP 0.490 gm

L-Lysine Hydrochloride USP 0.430 gm

L-Methionine USP 0.225 gm

L-Phenylalanine USP 0.533 gm

L-Threonine USP 0.250 gm

L-Tryptophan USP 0.090 gm

L-Valine USP 0.360 gm

L-Arginine Hydrochloride USP 0.500 gm

L-Histidine Hydrochloride Monohydrate BP 0.250 gm

L-Aspartic Acid USP 0.250 gm

L - Glutamic Acid BP 0.075 gm

L-Alanine USP 0.200 gm

L-Cystine BP 0.010 gm

Glycine (2-Amino Acetic Acid) BP 0.760 gm

L-Proline USP 0.100 gm

L-Serine USP 0.100 gm

L-Tyrosine USP 0.025 gm

 

ii) Excipients

D-Sorbitol BP 5.000 gm

Water for injection BP q.s

Electrolytes (mmol/l)

Sodium 40.0

Potassium 25.0

Magnesium 2.5

Chloride 43.5

Acetate 25.0

Energy content: 155 Kj/L (371.14 Kcal/L)

Nitrogen content: 7.2 gm/L

Amino Acids consists of 18 essential and non-essential amino acids which are needed for protein synthesis as well as body build up. The amino acid composition is such that positive nitrogen balance can be achieved in the post-operative period and during extended periods of intravenous nutrition.

Uses

Amino Acids is used for a source of amino acids for protein synthesis in patients needing intravenous nutrition. It is particularly suitable for a patient with basal amino acid requirements. Amino Acids is also used for faster recovery in surgery, burns, renal insufficiency, hepatic insufficiency and effective management of Cancer.

Aminosol is also used to associated treatment for these conditions: Creatinine Clearance 5-15 mL/min, Uremia, Nutritional Support, Parenteral Nutrition, Total parenteral nutrition therapy

Trade Name Aminosol
Generic Amino acids
Other Names Amino acids NOS
Weight 5%,
Type Iv Infusion, Ampule
Therapeutic Class Parenteral Nutritional preparations
Manufacturer Opso Saline Ltd, Grand Pharmaceutical Co Ltd, Grand Pharmaceutical Co, Ltd,
Available Country Bangladesh, Philippines
Last Updated: June 23, 2021 at 11:16 am

Dosage

Aminosol dosage

Adults:

The nitrogen requirement for maintenance of body protein mass depends on the patient's condition (nutritional state and degree of metabolic stress).

No or minor metabolic stress and normal nutritional state: 0.10-0.15 g nitrogen/kg/day,

Moderate metabolic stress with or without malnutrition: 0.15-0.20 g nitrogen/kg/day,

Severe catabolism as in burns, sepsis and trauma: up to 0.20-0.25 g nitrogen/kg/day.

 

The dosage range 0.10-0.25 g nitrogen/kg/day corresponds to 15-35 ml Amino Acids/kg/day.

In obese patients, the dose should be based on the estimated ideal weight. Depending upon patients requirements, 1000-2000 ml Amino Acids may be infused intravenously per 24 hours. Amino Acids should be infused slowly, at rates 1.4-2.8 ml (30-60 drops) per minute.

Infants and Children:

In children and infants, the rate of infusion is 28-35 ml/kg body wt/day is recommended, with a stepwise increment in the rate of administration during the first week of treatment.

Side Effects

Amino Acids is usually well tolerated. Yet nausea, vomiting, flushing and sweating have been observed during infusion of Amino Acids at rates exceeding the recommended maximal rate. Hypersensitivity reactions have been reported. Like all hypertonic infusion solution, thrombophlebitis may occur when peripheral veins are used. The incidence may be reduced by the simultaneous infusion of 10% fat emulsion. If it is infused to severely ill patients, premature infants, hyperphenylalaninemia may occur.

Precaution

Hyperphenylalaninemia has been noted in severely ill, premature infants. In these patients, monitoring of the phenylalanine levels is recommended and the infusion rate adjusted as needed.

Do not use if the solution is turbid or contains particles. Discard any unused portion.

Pregnancy & Breastfeeding use

Successful and safe administration of amino acid solutions during pregnancy in the human has been reported. Animal reproduction studies have not been carried out with Amino Acids.

Contraindication

Amino acid is contraindicated in patients with inborn errors of amino acids metabolism, irreversible liver damage and severe uremia when dialysis facilities are not available.

Special Warning

In children and infants, the rate of infusion is 28-35 ml/kg body weight per day is recommended, with a step wise increase in the rate of administration during the first week.

Storage Condition

Protect from light and store between 15-25 °C temperature. Avoid freezing. Keep medicament's out of reach of children.

FAQ

What does Aminosol used for?

Aminosol is used for depressive illness, treating pain, back pain, prevent migraine attacks particularly with anxiety and nocturnal enuresis in children.

Does Aminosol a sleeping pill?

Aminosol has been around for many years and is an inexpensive option as a sleep aid. Aminosol and antidepressants like it are commonly used off-label to treat insomnia, especially in people who also have symptoms of depression.

What are the side effects of Aminosol?

Aminosol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • drowsiness
  • weakness or tiredness
  • nightmares
  • headaches
  • dry mouth
  • constipation
  • difficulty urinating
  • blurred vision
  • pain, burning, or tingling in the hands or feet
  • changes in sex drive or ability
  • excessive sweating
  • changes in appetite or weight
  • confusion
  • unsteadiness

How does Aminosol help with pain?

It works on two chemicals, noradrenaline and serotonin, that are found in nerves. When Aminosol is used to treat nerve pain, it lowers the pain signals to the brain. This helps to reduce the level of pain you experience, which can enable you to get back to your daily activities and have a better quality of life.

What drugs should not be taken with Aminosol?

Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication.

When should to take Aminosol?

It's usual to take Aminosol once a day before bedtime because it can make you feel sleepy. If you find that you are still feeling drowsy in the morning you could try taking it earlier in the evening.

How long before you go to bed should you take Aminosol?

Amitriptyline is available as tablets or syrup, taken daily. As it has a sedative effect and may make you drowsy, it's usually taken an hour or two before bedtime (but no later than 8 pm). Your doctor will advise you about the correct dose.

Can I drink coffee while taking Aminosol?

To avoid this interaction avoid coffee one hour before and two hours after taking medications for depression called tricyclic antidepressants. 

How long should I take Aminosol for nerve pain?

You may notice pain relief as quickly as two weeks after starting, but often Aminosol requires to be taken for six to eight weeks at the optimal dose level before one can say the drug has been given a fair trial.

What happens when I stop taking Aminosol?

If you stop taking the drug suddenly or don't take it at all: If you don't take Aminosol, your depression may worsen. If you stop taking this medication suddenly you may have withdrawal side effects such as nausea, headache, and tiredness.

Does Aminosol cause depression?

Aminosol may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these adverse effects, tell your doctor right away.

How do I stop taking Aminosol?

If you want to stop taking Aminosol, go to the doctor and they will help you to bring the dose down gradually. This will take a few weeks. You may still get some withdrawal effects, especially during the first two weeks as you reduce the dose. These effects will go away as you carry on reducing the dose.

How does amitriptyline work?

Amitriptyline is a type of medicine called a tricyclic antidepressant (TCA). These medications work by increasing certain brain chemicals called neurotransmitters like serotonin and norepinephrine to help improve mood, sleep, pain, and anxiety. It’s not clear exactly how amitriptyline works for sleep, but one of its effects is to block histamine, which may result in drowsiness. This is one reason doctors prescribe amitriptyline as a sleep aid.

What is Aminosol?

Aminosol is a prescription drug available as a tablet in several strengths. It’s approved for use to treat depression but is also often prescribed for several other conditions like pain, migraines, and insomnia. Although it has been around for many years, it is still a popular, low-cost generic medication.