Aminoplex Iv Infusion

Each 100 ml contains-Essential Amino Acids:

  • L-Isoleucine 0.390 gm
  • L-Leucine 0.530 gm
  • L-Lysine Hydrochloride 0.390 gm
  • L-Methionine 0.190 gm
  • L-Phenylalanine 0.550 gm
  • L-Threonine 0.300 gm
  • L-Tryptophan 0.100 gm
  • L-Valine 0.430 gm
  • L-Histidine 0.240 gm
  • L-Tyrosine 0.050 gm

Non-Essential Amino Acids:

  • L-Arginine 0.330 gm
  • L-Aspartic Acid 0.410 gm
  • L-Glutamic Acid 0.900 gm
  • L-Alanine 0.300 gm
  • L-Cystine 0.140 gm
  • Glycine (Aminoacetic Acid) 0.210 gm
  • L-Proline 0.810 gm
  • L-Serine 0.750 gm

Carbohydrate:

  • Anhydrous Glucose 10.00 gm

Electrolytes:

  • Sodium (Na+) 50.0 mmol/L
  • Potassium (K+) 20.0 mmol/L
  • Calcium (Ca++) 2.5 mmol/L
  • Magnesium (Mg++) 1.5 mmol/L
  • Chloride (Cl-) 32.0 mmol/L

A crystalline amino acid solution provides crystalline amino acids to promote protein synthesis and wound healing, and to reduce the rate of endogenous protein catabolism. Amino Acids given by central venous infusion in combination with concentrated dextrose, electrolytes, vitamins, trace metals, and ancillary fat supplements, constitutes total parenteral nutrition (TPN). Amino Acids can also be administered by peripheral vein with dextrose and maintenance electrolytes.

Uses

This is used for a source of amino acids, glucose and electrolytes in adult and pediatric patients needing IV nutrition. This is particularly suitable for patients with basal amino acid requirements.

Trade Name Aminoplex
Generic Amino Acid + Glucose & Electrolytes
Weight 7%+10%, 5%
Type Iv Infusion
Therapeutic Class Parenteral Nutritional preparations
Manufacturer Acme Laboratories Limited
Available Country Bangladesh
Last Updated: June 23, 2021 at 11:16 am

Dosage

Aminoplex dosage

Adults: The nitrogen requirement for maintenance of body protein mass depends on the condition of the patient (nutritional state and degree of metabolic stress). The requirements are 0.1-0.15 g nitrogen/kg body weight/day (no or minor metabolic stress and normal nutritional state), 0.15-0.2 g nitrogen/kg body weight/day (moderate metabolic stress with or without malnutrition) and up to 0.2-0.25 g nitrogen/kg body weight/day (severe catabolism as in burns, sepsis and trauma). The dosage range 0.1-0.25 g nitrogen/kg body weight/day corresponds to 11-27 mL Amino Acid IV Infusion with 10% Glucose and Electrolytes /kg body weight/day, respectively. 

Obese patient: In obese patients, the dose should be based on the estimated ideal weight. Depending upon patient requirements, up to 1000-2000 mL of Amino Acid IV Infusion with 10% Glucose and Electrolytes may be infused IV per 24 hrs. Amino Acid IV Infusion with 10% Glucose and Electrolytes should be infused slowly, at a rate not exceeding 1000 mL in 6 hrs corresponding to approximately 2.8 mL/min. In patients with basal amino acids requirements, the less concentrated Amino Acid IV Infusion with 10% Glucose and Electrolytes may be used. 

Infants and Children: In children and infants, a maximal rate of infusion of 30 mL Amino Acid IV Infusion with 10% Glucose and Electrolytes/kg body weight/day is recommended, with a stepwise increase in the rate of administration during the 1st week of treatment.

Side Effects

Nausea occurs rarely. Transient increases in liver tests during IV nutrition have been reported. Hypersensitivity reactions have been reported with amino acid solutions. As with all hypertonic infusion solutions, thrombophlebitis may occur when peripheral veins are used. Hyperphenylalaninemia may occur in severely ill, premature infants.

Precaution

This IV infusion is accompanied by increased urinary excretion of the trace elements copper and, in particular zinc, which should be taken into account in the dosing of trace elements, particularly during long-term IV nutrition. Hyperphenylalaninemia has been noted in severely ill premature infants. In these patients, monitoring of the phenylalanine level is recommended and the infusion rate adjusted as needed. This should be used with caution in patients with diabetes mellitus, severe heart failure or with renal function in combination with fluid restrictions or oliguria / anuria of other origin. In patients with hyperglycemia, administration of exogenous insulin might be necessary.

Interaction

At the recommended dosage the amino acid have no pharmacological effects and is not expected to interact with other medicaments.

Pregnancy & Breastfeeding use

No specific studies have been performed to assess the safety of Amino Acids + Electrolytes + Glucose in pregnancy and lactation. The prescriber should consider the benefit/risk relationship before administering this combination to pregnant or breastfeeding women.

Contraindication

Patients with inborn errors of amino acid metabolism, severe liverdysfunction and in severe uremia when dialysis facilities are not available. Due to the content of glucose,this drug is contraindicated in patients with hyperosmolar nonketotic diabetic coma.

Acute Overdose

If Amino Acid, Glucose & Electrolytes combination is administered at a higher rate than recommended, there is an augmented risk for nausea, vomiting and sweating. When peripheral veins are used thrombophlebitis may occur. Osmotic diuresis with dehydration may occur if the dosage recommendations are exceeded. There is also a risk of symptoms related to hyperglycemia. In case of symptoms due to overdose, the infusion should be slowed down or discontinued.

Storage Condition

Protect from light and store between 15° C to 25° C temperature. Avoid freezing.

Aminoplex contains Amino Acid + Glucose & Electrolytes see full prescribing information from innovator Monograph

FAQ

What is the use of Aminoplex?

Aminoplex is used to treat mental depression that occurs with anxiety or nervous tension.

How does Aminoplex works?

Chlordiazepoxide belongs to a class of drugs called benzodiazepines. Amitriptyline belongs to a class of drugs called tricyclic antidepressants. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Amitriptyline/chlordiazepoxide works on your central nervous system. It increases the level of certain chemicals in your brain. This improves your symptoms of depression and anxiety.

What is the side effects of Aminoplex?

Aminoplex tablet may cause dizziness and drowsiness during the first few hours after you take it. 
More common side effects of Aminoplex are

  • drowsiness
  • dry mouth
  • nasal congestion
  • constipation
  • blurred vision
  • dizziness
  • bloating
  • vivid dreams
  • tremors (uncontrollable rhythmic movements in one part of your body)
  • erectile dysfunction (trouble getting or keeping an erection)
  • confusion

Is Aminoplex safe during breastfeeding?

There are no adequate studies in women for determining infant risk when taking during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

can I drink alcohol with Aminoplex?

The use of drinks that contain alcohol can increase your risk of sedation and drowsiness to dangerous levels from this drug. If you drink alcohol, talk to your doctor.

Is Aminoplex safe in pregnancy?

Safe use of Aminoplex during pregnancy has not been established. The chlordiazepoxide component of this drug has been shown to increase the risk of negative effects to the fetus. This risk is higher during the first trimester of pregnancy. Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk.