Amboten SR Capsule (Sustained Release)

Amboten SR is a metabolite of Bromhexine. It possesses mucokinetic (improvement in mucus transport) and secretolytic (liquefies secretions) properties. Amboten SR stimulates the serous cells of the glands of the mucous membrane of bronchi, increasing the content of mucus secretion. The mucolytic effect is associated with depolymerization and splitting of mucoproteins and mucopolysaccharide fibres, which leads to reduction in the viscosity of mucus. Expectoration of mucus is facilitated and breathing is eased considerably. Amboten SR stimulates production of phospholipids of surfactant by alveolar cells. Amboten SR has anti-inflammatory properties. In patients with COPD, it improves airway patency. Beside these, Amboten SR also exhibits anti-oxidant activity. Long-term use is possible because of the good tolerability of the preparation.

Uses

  • • Acute and chronic diseases of respiratory tracts associated with viscid mucus including acute and chronic bronchitis
  • • Productive cough
  • • Inflammatory diseases of Rhinopharyngeal tract (e.g. Laryngitis, Pharyngitis, Sinusitis and Rhinitis) associated with viscid mucus
  • • Asthmatic bronchitis, Bronchial asthma with difficult departure of mucus
  • • Bronchiectasis
  • • Chronic pneumonia.

Amboten SR is also used to associated treatment for these conditions: Airway secretion clearance therapy

Trade Name Amboten SR
Generic Ambroxol
Other Names Ambroxol, Ambroxolum, Bisolvon metabolite vIII, Bromhexine metabolite vIII, Bromhexine-metabolite vIII
Weight 75mg
Type Capsule (Sustained Release)
Formula C13H18Br2N2O
Weight Average: 378.108
Monoisotopic: 375.978589
Protein binding

Approximately 90%

Therapeutic Class Cough expectorants & mucolytics
Manufacturer Eskayef Bangladesh Ltd
Available Country Bangladesh
Last Updated: June 23, 2021 at 11:16 am

Dosage

Amboten SR dosage

Average daily dose (preferably after meal):Pediatric Drops: 

  • 0-6 months: 0.5 ml 2 times a day
  • 6-12 months: 1 ml 2 times a day
  • 1-2 years: 1.25 ml 2 times a day

Syrup: 

  • 2-5 years: 2.5 ml (1/2 teaspoonful) 2-3 times a day
  • 5-10 years: 5 ml (1 teaspoonful) 2-3 times a day
  • 10 years and adults: 10 ml (2 teaspoonful) 3 times a day.

Sustained release capsule: 

  • Adult and children over 12 years old: 1 capsule once daily

Specific application features: Amboten SR may be prescribed to patients suffering from diabetes mellitus.

Side Effects

Gastrointestinal side-effects like epigastric pain, gastric fullness may occur occasionally. Rarely allergic responses such as eruption, urticaria or angioneurotic edema may occur.

Precaution

Amboten SR should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders. Patients with hepatic and renal insufficiency should take it with caution.

Interaction

Amboten SR has no interaction with cardioactive glycosides, corticosteroids, bronchodilators, diuretics and antibiotics (normally used in the treatment of bronchopulmonary affections). But Amboten SR should not be taken simultaneously with antitussives (e.g. Codeine) because mucus, which has been liquefied by Amboten SR, might not be expectorated.

Half Life

7-12 hours

Pregnancy & Breastfeeding use

Pregnancy: Teratogenic and fetal toxicity studies have shown no harmful effect of Amboten SR. However, it is advised not to use during pregnancy, especially in the 1st trimester.

Lactation: Safety during lactation has not been established.

Contraindication

Contraindicated in known hypersensitivity to Amboten SR or Bromhexine.

Interaction with other Medicine

Amboten SR has no interaction with cardioactive glycosides, corticosteroids, bronchodilators, diuretics and antibiotics (normally used in the treatment of bronchopulmonary affections). But Amboten SR should not be taken simultaneously with antitussives (e.g. Codeine) because mucus, which has been liquefied by Amboten SR, might not be expectorated.

Amboten SR contains Ambroxol see full prescribing information from innovator Monograph