Aluminum chloride
Aluminum chloride Uses, Dosage, Side Effects, Food Interaction and all others data.
Aluminum chloride is a chemical compound with the chemical formula AlCl3. When contaminated with iron chloride, it often displays a yellow color compared to the white pure compound. It is used in various chemical applications as a Lewis base, with anhydrous aluminium trichloride being the most commonly used Lewis acid. It may also be found in over-the-counter as an antiperspirant or prescription products as an antihemorrhagic agent. In antiperspirant products, FDA approves the use of aluminum chloride as an active ingredient up to 15%, calculated on the hexahydrate form, in an aqueous solution nonaerosol dosage form .
Aluminum chloride is a hemostatic and antiperspirant agent.
| Trade Name | Aluminum chloride |
| Generic | Aluminum chloride |
| Aluminum chloride Other Names | Aluminium chloride |
| Type | |
| Formula | AlCl3 |
| Weight | Average: 133.341 Monoisotopic: 131.888096562 |
| Protein binding | Following oral administration of 8.1 mg/kg of aluminum chloride, the fraction of plasma protein binding of aluminum was approximately 98 % . |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
- Indicated for the control of minor hemorrhage during dental restorative procedures.
- Indicated to reduce underarm perspiration.
Aluminum chloride is also used to associated treatment for these conditions: Excessive sweating and body odor, Hyperphosphataemia, Minor bleeding
How Aluminum chloride works
Aluminum chloride is commonly used topical antiperspirant. It is proposed that aluminum chloride works by causing an obstruction of the distal sweat gland ducts, where the metal ions precipitate with mucopolysaccharides, damaging epithelial cells along the lumen of the duct and forming a plug that blocks sweat output . Aluminum chloride is also an astringent that promotes hemostasis; it precipitates proteins on the superficial layer of mucosa and make it mechanically stronger . It creates superficial and local coagulation in minor hemorrhages.
Toxicity
Oral LD50 is 3470 mg/kg in rat and dermal LD50 is > 2 g/kg in rabbit . As aluminum accumulates in the brain, ataxia and seizures may be observed following ingestion of higher doses. Mental status changes, including obtundation, lethargy and confusion may be seen . Liver damage has been reported in acute and chronic toxicity of aluminum .
Food Interaction
No interactions found.Volume of Distribution
Following oral administration of 8.1 mg/kg of aluminum chloride, the steady‐state volume of distribution of aluminum was 38.4 ± 6.4 mL/kg .
Elimination Route
It is reported that about 17-30 % of aluminum chloride formed from the reaction between orally ingested aluminum hydroxide and hydrochloric acid of the stomach is absorbed . In rabbits, administration of a single maximum safe oral dose aluminum chloride (333 mg Al/kg) resulted in aluminum absorption of 0.57 % . Aluminum chloride may be absorbed via dermal route, with the uptake increasing in the microgram range but with an upper limit .
Half Life
Following oral administration of 8.1 mg/kg of aluminum chloride, the half-life of aluminum was 5.29 ± 0.47 h .
Clearance
Following oral administration of 8.1 mg/kg of aluminum chloride, the clearance of aluminum was 8.87 ± 1.76 mL/(h*kg) .
Elimination Route
Absorbed aluminum chloride is rapidly excreted by the kidneys in individuals with normal renal function . Aluminum chloride may be absorbed dermally.
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