Alprazol is a triazolo analogue of the 1,4-benzodiazepine class of drugs. It is an anxiolytic with hypnotic and anticonvulsive properties. Alprazol is presumed to produce its effects via interacting with the Gamma Aminobutyric Acid (GABA) - benzodiazepine receptor complex. Like all benzodiazepines, it causes a dose related CNS depressant activity varying from mild impairment of task performance to hypnosis.
- * Anxiety disorder
- * Short term relief of anxiety
- * Anxiety associated with depression
- * Panic disorder, with or without agoraphobia.
Alprazol is also used to associated treatment for these conditions: Anxiety, Generalized Anxiety Disorder (GAD), Panic Disorder
Alprazolam is 80% protein bound in serum. The majority of this protein binding is to serum albumin. Alprazolam is also bound to alpha1-acid glycoprotein with low frequency.
|Therapeutic Class||Benzodiazepine sedatives|
|Manufacturer||Theo Pharmaceuticals Ltd, Albion Pharmaceuticals Ltd|
|Available Country||India, Bangladesh|
|Last Updated:||June 23, 2021 at 9:00 am|
Table Of contents
Treatment should be initiated with a dose of 0.25 to 0.5 mg three times daily. Depending on the response, dose may
be increased at intervals of 3 to 4 days in increments of no more than 1 mg per day. The maximum dose should not
exceed 4 mg/day. Occasional patients with panic disorder may need as much as 10 mg a day to achieve a
successful response and in these cases periodic reassessment and consideration of dosage adjustment is required.
Dosage should be individualized for maximum beneficial effect with a lowest possible dose. If side-effects occur at
starting dose, dose may be lowered. When discontinuing therapy, dosage should be reduced gradually by no more
than 0.5 mg every three days.
In elderly patients or in patients with advanced liver disease, the usual starting dose is 0.25 mg, two or three times
daily and may be gradually increased if needed and tolerated. Safety and effectiveness of Alprazol in individuals
below 18 years of age have not been established.
Alprazol XR 1 should be administered once daily, preferably in the morning by patients who are on multiple dosage
regimen of Alprazol 0.25/0.5 mg. The tablets should be taken intact, they should not be chewed, crushed, or broken.
Side effects, if occur, are generally observed at the beginning of therapy and usually disappear upon continued medication. The most frequent side effects are drowsiness and light headedness. The other side effects, that may occur include depression, headache, confusion, dry mouth, constipation etc.
Because Alprazol may produce psychological and physical dependence, increment of dose or abrupt discontinuation of Alprazol therapy should not be done without physician's advice. Duration of therapy must be determined by the physicians. Alprazol should be administered with caution to patients with hepatic or renal disease, chronic pulmonary insufficiency or sleep apnea.
Alprazol produces additive CNS depressant effects when co-administered with other psychotropic medications, anticonvulsants, antihistaminics, ethanol and other drugs which themselves produce CNS depression.
- Avoid alcohol. Alcohol may potentiate the CNS depressant effects of this drug.
- Avoid grapefruit products.
- Limit caffeine intake.
- Take with or without food. Food increases the Cmax of extended release alprazolam by 25%, but the AUC and half life are not affected.
Volume of Distribution
Volume of distribution following oral administration is 0.8-1.3L/kg. Alprazol crosses the blood-brain barrier.
11.2 hours in healthy patients. The half life is 16.3h in the elderly, 5.8-65.3h in patients with alcoholic liver disease, 9.9-40.4h in obese patients. The half life is 25% higher in Asian patients compared to Caucasians. Other studies have shown the half life to be 9-16h.
Oral clearance is 0.90±0.21mL/min/kg but this increases to 2.13±0.54mL/min/kg when given with CYP3A inducers. Other studies have demonstrated a clearance of 0.70-1.5mL/min/kg.
Pregnancy & Breastfeeding use
Pregnancy: Alprazol has been categorized in pregnancy category D; that means, it should be avoided in pregnancy.
Lactation: Like other benzodiazepines, Alprazol is assumed to be excreted in breast milk. Therefore, nursing should not be undertaken by mothers who must use Alprazol.
Contraindicated in patients with hypersensitivity to alprazolam or other benzodiazepines. Alprazol is also contraindicated in patients with myasthenia gravis, acute narrow angle glaucoma, during pregnancy and also in infants.
Use in Children: Safety and efficacy of Alprazol in patients under the age of 18 years has not been established.
Manifestations of Alprazol over dosage include somnolence, confusion, impaired coordination, diminished reflexes and coma. In such cases of over dosage general supportive measures should be employed along with immediate gastric lavage.
Interaction with other Medicine
The CNS-depressant action of Alprazol may be aggravated by concomitant use of other psychotropic drugs, anticonvulsants, antihistaminics, alcohol and oral contraceptives.
Alprazol tablets should be stored in a cool and dry place, protected from light and moisture.
What does Alprazol do?
Alprazol is used to treat anxiety and panic disorders. It belongs to a class of medications called benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. It works by enhancing the effects of a certain natural chemical in the body (GABA).
What is Alprazol used for?
Alprazol is used to treat anxiety disorders and panic disorder (sudden, unexpected attacks of extreme fear and worry about these attacks). Alprazolam is in a class of medications called benzodiazepines. It works by decreasing abnormal excitement in the brain.
Is Alprazol a sleeping pill?
Alprazol belong to a class of medicines called benzodiazepines and hydrocodone belongs to the class of medicines called opioids. Both the classes cause sedation (increased tendency to sleep) and respiratory depression (slow and difficult breathing).
What are the side effects of Alprazol?
Common side effects of Alprazol include:
- Headache pain
- Dry mouth
- Impaired coordination
- Increased or decreased appetite
- Memory problems
- Decreased salivation
- Cognitive disorders
- Difficulty speaking
- Weight gain or weight loss
- Nasal congestion
- Decreased or increased libido
- Menstrual disorder
- Difficulty urinating
- Fast heart rate
- Blurred vision
- Low blood pressure (hypotension)
- Increased salivation
What should avoid while taking Alprazol?
Notes for Consumers: Grapefruit juice and grapefruit-containing foods may increase the actions or side effects (such as drowsiness or slowed breathing) of Alprazol. Avoid taking Alprazol with grapefruit juice (or grapefruit) whenever possible, and do not increase your intake of grapefruit while taking Alprazol.
Does anyone take Alprazol daily?
People stop feeling the effects of Alprazol long before it leaves the body, which is why it is often taken more than once a day. It's important to take it as prescribed. Taking too many doses can lead to dependence and accidental overdose.
Is Alprazol a steroid?
Alprazol is a Schedule IV controlled substance and is a common drug of abuse.
Is Alprazol an antidepressant?
Alprazol appears to be an effective antidepressant in the treatment of outpatients who have a diagnosis of major depressive disorder. The authors have reviewed six controlled double-blind studies of Alprazol in the treatment of depression.
Does Alprazol cause liver damage?
Alprazol, like other benzodiazepines, is rarely associated with serum ALT elevations, and clinically apparent liver injury from Alprazol is extremely rare. There have been a few case reports of acute liver injury from Alprazol and recurrence on reexposure has been reported.
Is one .25 Alprazol a day addictive?
Alprazol is a benzodiazepine used to treat anxiety and insomnia. The drug is extremely addictive and should only be used under a doctor's supervision.
Will doctors prescribe Alprazol long-term?
It can be used short-term as a way to offer people immediate relief from their symptoms or as part of a long-term management plan for GAD or panic disorder. Alprazol is often prescribed for panic attacks, which can occur as part of SAD.
How long should I take Alprazol?
Alprazol is a powerful benzodiazepine that is only recommended for use for up to six weeks.
Does Alprazol cause memory loss?
Several research studies have found that chronic or heavy Alprazol use can cause short-term memory loss. This is listed by the National Institutes of Health (NIH) as one of the more serious side effects of Alprazol requiring immediate medical attention.
Does Alprazol help with racing thoughts?
Alprazol may be prescribed to treat symptoms of the manic phase of bipolar disorder. These symptoms include: racing thoughts and speech. high energy.
Can Alprazol help mild depression?
Alprazol is a medication that is approved by the Food and Drug Administration (FDA) to treat anxiety and panic disorders. Alprazol, which is the Alprazol name for the generic drug alprazolam, isn't usually used to treat depression because there are several newer and safer medications available.
Is Alprazol safe to use?
Alprazol is a safe and effective medication when used as directed. Benzodiazepines may produce emotional and/or physical dependence (addiction) even when used as recommended. Physical dependence may develop after 2 or more weeks of daily use.
What is the most Alprazol a doctor can prescribe?
For anxiety disorders, the dosage for adults typically starts at 0.25 mg to 0.5 mg three times per day. A doctor may incrementally increase the dosage to maximize the effect. However, the maximum dosage does not usually exceed 4 mg per day. For panic disorders, the required dose of Alprazol may exceed 4 mg per day.
Can Alprazol make anxiety worse?
Recent studies evaluating the effectivity of Alprazol for anxiety have shown that after just 8 weeks, those that were on a Alprazol prescription had worse anxiety than those who took a placebo. Despite these results, doctors continue to prescribe these benzos for anxiety disorders at an alarming rate.
How long does the Alprazol high last for?
Alprazol has an average half-life of roughly 11 hours in healthy adults. In other words, it takes 11 hours for the average healthy person to eliminate half of the dose of Alprazol.