Allernix Multi Symptom
Allernix Multi Symptom Uses, Dosage, Side Effects, Food Interaction and all others data.
Allernix Multi Symptom is a long-acting, tricyclic, non-sedating, selective peripheral histamine H1-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils.
Allernix Multi Symptom is a long-acting second-generation H1-receptor antagonist which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, such as the swelling of tissues. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals which produce the effects that we associate with allergies. Allernix Multi Symptom blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of cells by histamine. Unlike most other antihistamines, Allernix Multi Symptom does not enter the brain from the blood and, therefore, does not cause drowsiness.
| Trade Name | Allernix Multi Symptom |
| Availability | Prescription only |
| Generic | Desloratadine |
| Desloratadine Other Names | Descarboethoxyloratadine, Desloratadina, Desloratadine |
| Related Drugs | prednisone, cetirizine, loratadine, fluticasone nasal, promethazine, diphenhydramine, Zyrtec, Xolair |
| Type | |
| Formula | C19H19ClN2 |
| Weight | Average: 310.821 Monoisotopic: 310.123676325 |
| Protein binding | Desloratadine is bound approximately 82 to 87% to plasma proteins, while its active metabolite, 3-hydroxydesloratadine, is bound approximately 85 to 89%. |
| Groups | Approved, Investigational |
| Therapeutic Class | Non-sedating antihistamines |
| Manufacturer | |
| Available Country | Canada, United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Allergic Rhinitis: Allernix Multi Symptom is used for the relief of the nasal and non-nasal symptoms of allergic rhinitis (Both seasonal and perennial) in patients 2 years of age and older.
Chronic Idiopathic Urticaria: Allernix Multi Symptom is also used for the symptomatic relief of pruritus, reduction in the number of hives, and size of hives, in patients with chronic idiopathic urticaria 2 years of age and older.
Allernix Multi Symptom is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Asthma, Chronic Idiopathic Urticaria, Common Cold, Nasal Congestion, Perennial Allergic Rhinitis (PAR), Seasonal Allergic Rhinitis, Nasal symptoms, Non-nasal symptoms, Antihistamine
How Allernix Multi Symptom works
Like other H1-blockers, Allernix Multi Symptom competes with free histamine for binding at H1-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine.
Dosage
Allernix Multi Symptom dosage
Pediatric drops :
- Child 6 -11 months of age: 2 ml drops once daily
- Child 1 -2 years of age: 2.5 ml drops once daily
Syrup:
- Child 6-11 months of age: 2 ml once daily
- Child 1-5 years of age: 2.5 ml once daily
- Child 6-11 years of age: 5 ml once daily
- Adults & > 12 years of age: 10 ml once daily
Tablet:
- Adults and children 12 years of age and over: 5 mg daily
Side Effects
Allernix Multi Symptom is generally well tolerated. However, dry mouth, fatigue, somnolence and myalgia are commonly reported side-effects. Less common side-effects may include dizziness, headache and nausea. Rarely rash, pruritus and urticaria may occur.
Toxicity
Information regarding desloratadine overdose is limited, although somnolence has been reported. In case of overdose, symptomatic and supportive treatment, including removing the unabsorbed drug, is recommended; note, however, that desloratadine and its active metabolite 3-hydroxydesloratadine cannot be eliminated by hemodialysis.
In animal studies, lethality was observed at or above doses of 250 mg/kg in rats and of 353 mg/kg in mice (oral LD50), doses that represent 120 and 290 times the human exposure based on the recommended daily oral dose. In monkey, no deaths occurred at doses up to 250 mg/kg, representing an exposure roughly 810 times that of the recommended dose in humans.
Precaution
Hepatic and renal impairment. Pregnancy and lactation.
Interaction
Concomitant administration of Erythromycin, Ketoconazole, Azithromycin, Fluoxetine, and Cimetidine with Allernix Multi Symptom increased the plasma concentration of Allernix Multi Symptom. But there were no clinically relevant changes in the safety profile of Allernix Multi Symptom.
Food Interaction
- Take with or without food. The absorption is unaffected by food.
Allernix Multi Symptom Disease Interaction
Elimination Route
Allernix Multi Symptom administered orally for ten days to healthy volunteers as a 5 mg tablet once daily resulted in a mean Tmax of approximately 3 hours, a mean steady-state Cmax of 4 ng/ml, and a mean steady-state AUC of 56.9 ng*hr/ml. A similar profile was observed using 10 ml of an oral solution containing 5 mg of desloratadine. Food was found not to affect desloratadine absorption.
Half Life
Allernix Multi Symptom has a mean plasma elimination half-life of approximately 27 hours.
Elimination Route
Approximately 87% of a C-desloratadine dose was equally recovered in urine and feces as metabolic products.
Pregnancy & Breastfeeding use
Pregnancy: There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, Allernix Multi Symptom should be used in pregnancy only if clearly needed.
Lactation: Allernix Multi Symptom passes into breast milk. Therefore, a decision should be made whether to discontinue nursing or to discontinue Allernix Multi Symptom, taking into account the importance of the drug to the mother.
Contraindication
Allernix Multi Symptom is contraindicated in patient having hypersensitivity to this medication or to any of its ingredients or Loratadine.
Special Warning
Paediatric Use: The safety and effectiveness of Allernix Multi Symptom in pediatric patients under 2 years of age have not been established.
Geriatric Use: In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
In adult patients with liver or renal impairment: A starting dose of one 5 mg tablet every other day is recommended based on pharmacokinetic data.
Acute Overdose
No clinically relevant adverse events have been reported in case of overdosage. However, in the event of overdosage, symptomatic and supportive treatment is recommended.
Storage Condition
Store in a cool and dry place, protected from light.
Innovators Monograph
You find simplified version here Allernix Multi Symptom
Allernix Multi Symptom contains Desloratadine see full prescribing information from innovator Allernix Multi Symptom Monograph, Allernix Multi Symptom MSDS, Allernix Multi Symptom FDA label
FAQ
What is Allernix Multi Symptom used for?
Allernix Multi Symptom is an antihistamine used to relieve allergy symptoms such as watery eyes, runny nose, itching eyes/nose, sneezing, hives, and itching. Allernix Multi Symptom is used to treat allergies. It is an active metabolite of loratadine. It is used to relieve the symptoms of hay fever and hives of the skin.
How safe is Allernix Multi Symptom?
Allernix Multi Symptom is a safe and effective treatment for allergic diseases.
How does Allernix Multi Symptom work?
Allernix Multi Symptom works by blocking histamine, a substance in the body that causes allergic symptoms.
What are the common side effects of Allernix Multi Symptom?
Common side effects of Allernix Multi Symptom are include:
- headache.
- nausea.
- diarrhea.
- dizziness.
- sore throat.
- dry mouth.
- muscle pain.
- extreme tiredness
Is Allernix Multi Symptom safe during pregnancy?
As such these findings provide reassurance by indicating that the fetal safety of Allernix Multi Symptom is similar to the currently recommended antihistamines during pregnancy and thus Allernix Multi Symptom can be considered to be another option for use during pregnancy.
Is Allernix Multi Symptom safe during breastfeeding?
Considering the minimal exposure of a nursing infant to the drugs through breast milk, maternal use of Allernix Multi Symptom dose is unlikely to result in adverse effects in nursing infants and is considered to be compatible with breastfeeding.
Can I drink alcohol with Allernix Multi Symptom?
Allernix Multi Symptom alone or in combination with alcohol was safe and well tolerated.
Can I drive after taking Allernix Multi Symptom?
Do not drive and do not use tools or machines.
When should be taken of Allernix Multi Symptom?
You can take Allernix Multi Symptom before or after meals.
Can I take Allernix Multi Symptom every day?
The recommended dose of Allernix Multi Symptom tablets is one 5 mg tablet once daily.
How long does Allernix Multi Symptom take to work?
Allernix Multi Symptom is also use to relieve the symptoms of allergic skin conditions such as skin itch and hives. Allernix Multi Symptom usually starts to work within 75 minutes and lasts for 24 hours.
What is the half-life of Allernix Multi Symptom ?
The 27-hour half-life of Allernix Multi Symptom permits once daily administration.
How long can I take Allernix Multi Symptom for?
You can limit treatment to 14 days.
Can I take Allernix Multi Symptom for a long time?
Allernix Multi Symptom is unlikely to do you any harm if you take it for a long time. However, it's best to take it only for as long as you need to. It's best not to drink alcohol while you're taking Allernix Multi Symptom, as it can make you feel sleepy.
Who should not take Allernix Multi Symptom?
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happen if I overdose of Allernix Multi Symptom?
tiredness. sleepiness. menstrual pain. Increased sleepiness or tiredness can happen if you take more Allernix Multi Symptom than your doctor prescribed to you.
Can Allernix Multi Symptom cause infertility?
Allernix Multi Symptom is not expected to cause other pregnancy problems.
Does Allernix Multi Symptom increase blood pressure?
The decongestant in Allernix Multi Symptom and pseudoephedrine may cause blood pressure to increase and may also speed up the heart rate.
Can Allernix Multi Symptom affects my kidney?
Older patients are more likely to have kidney or liver problems which may make them more sensitive to the effects of Allernix Multi Symptom. Your doctor may give you a different Allernix Multi Symptom dose if you have kidney or liver problems.
