Alfa E Tablet
Alfa E Capsule is a Alfa E preparation. Alfa E acts as an antioxidant in the body. Alfa E protects polyunsaturated fatty acids (which are components of cellular membrane) and other oxygen-sensitive substances such as vitamin A & vitamin C from oxidation. Alfa E reacts with free radicals, which is the cause of oxidative damage to cell membranes, without the formation of another free radical in the process. The main pharmacological action of vitamin E in humans is its antioxidant effect.
In premature neonates irritability, edema, thrombosis and hemolytic anemia may be caused due to vitamin E deficiency. Creatinuria, ceroid deposition, muscle weakness, decreased erythrocyte survival or increased in vitro hemolysis by oxidizing agents have been identified in adults and children with low serum tocopherol concentrations.
As a dietary supplement:
- Alfa E deficiency resulting from impaired absorption.
- Increased requirements due to diet rich in polyunsaturated fats.
- For healthy hair & skin
- As an Antioxidant
- Hemolytic anemia due to Alfa E deficiency
: Heavy metal poisoning, Hepatotoxin poisoning, Hemolytic anemia, Oxygen therapy and replacement therapy in nutritional deficiency states for the betterment of skin and hair.
Alfa E is also used to associated treatment for these conditions: Vitamin Deficiency, Long-chain omega-3 fatty acid supplementation, Dietary supplementation
|Trade Name||Alfa E|
Vitamin E is bound to lipoproteins in blood.
|Therapeutic Class||Vitamin-E Preparations|
|Last Updated:||June 23, 2021 at 11:26 am|
Table Of contents
Alfa E dosage
Betterment of Cardiovascular health: 400 mg - 800 mg / day
Deficiency syndrome in adults: 200 mg - 400 mg / day
Deficiency syndrome in children: 200 mg / day
Thalassemia: 800 mg / day
Sickle-cell anemia: 400 mg / day
Betterment of Skin & Hair: 200 mg - 400 mg / day (Topical use is also established for beautification)
Chronic cold in adults: 200 mg / day
Overdoses (>1g) have been associated with minor side effects, including hypertension, fatigue, diarrhea and myopathy
Alfa E may enhance the anticoagulant activity of anticoagulant drugs. Caution is advised in premature infants with high dose Alfa E supplementation, because of reported risk of necrotizing enterocilitis.
Alfa E may impair the absorption of Vitamin A. Vitamin K functions impairement happens at the level of prothrombin formation and potentiates the effect of Warfarin.
- Take with or without food. High-fat foods may increase absorption of Alfa E.
Volume of Distribution
0.41L/kg in premature neonates given a 20mg/kg intramuscular injection.
44 hours in premature neonates given a 20mg/kg intramuscular injection. 12 minutes in intravenous injection of intestinal lymph.
6.5mL/hr/kg in premature neonates given a 20mg/kg intramuscular injection.
Pregnancy & Breastfeeding use
Use in pregnancy: Alfa E may be used in pregnancy in the normally recommended dose but the safety of high dose therapy has not been established.
Use in lactation: There appears to be no contraindication to breast feeding by mothers taking the normally recommended dose.
No known contraindications found.
Use in Children: Alfa E is safe for children
Large doses of vitamin E (more than 1 gm/day) have been reported to increase bleeding tendency in vitamin K deficient patients such as those taking oral anticoagulants.
Store at a cool and dry place, Protect from light and moisture.