Alfa E Tablet

Alfa E Capsule is a Alfa E preparation. Alfa E acts as an antioxidant in the body. Alfa E protects polyunsaturated fatty acids (which are components of cellular membrane) and other oxygen-sensitive substances such as vitamin A & vitamin C from oxidation. Alfa E reacts with free radicals, which is the cause of oxidative damage to cell membranes, without the formation of another free radical in the process. The main pharmacological action of vitamin E in humans is its antioxidant effect.

In premature neonates irritability, edema, thrombosis and hemolytic anemia may be caused due to vitamin E deficiency. Creatinuria, ceroid deposition, muscle weakness, decreased erythrocyte survival or increased in vitro hemolysis by oxidizing agents have been identified in adults and children with low serum tocopherol concentrations.

Uses

As a dietary supplement:

  • Alfa E deficiency resulting from impaired absorption.
  • Increased requirements due to diet rich in polyunsaturated fats.
  • For healthy hair & skin
  • As an Antioxidant
  • Hemolytic anemia due to Alfa E deficiency

Therapeutic use

: Heavy metal poisoning, Hepatotoxin poisoning, Hemolytic anemia, Oxygen therapy and replacement therapy in nutritional deficiency states for the betterment of skin and hair.

Alfa E is also used to associated treatment for these conditions: Vitamin Deficiency, Long-chain omega-3 fatty acid supplementation, Dietary supplementation

Trade Name Alfa E
Generic Vitamin E
Other Names alpha-tocopherol
Weight 200mg
Type Tablet
Formula C29H50O2
Weight Average: 430.7061
Monoisotopic: 430.381080844
Protein binding

Vitamin E is bound to lipoproteins in blood.

Therapeutic Class Vitamin-E Preparations
Manufacturer Aristopharma Ltd
Available Country Bangladesh
Last Updated: June 23, 2021 at 11:26 am

Dosage

Alfa E dosage

Betterment of Cardiovascular health: 400 mg - 800 mg / day

Deficiency syndrome in adults: 200 mg - 400 mg / day

Deficiency syndrome in children: 200 mg / day

Thalassemia: 800 mg / day

Sickle-cell anemia: 400 mg / day

Betterment of Skin & Hair: 200 mg - 400 mg / day (Topical use is also established for beautification)

Chronic cold in adults: 200 mg / day

Side Effects

Overdoses (>1g) have been associated with minor side effects, including hypertension, fatigue, diarrhea and myopathy

Precaution

Alfa E may enhance the anticoagulant activity of anticoagulant drugs. Caution is advised in premature infants with high dose Alfa E supplementation, because of reported risk of necrotizing enterocilitis.

Interaction

Alfa E may impair the absorption of Vitamin A. Vitamin K functions impairement happens at the level of prothrombin formation and potentiates the effect of Warfarin.

Food Interaction

  • Take with or without food. High-fat foods may increase absorption of Alfa E.

Volume of Distribution

0.41L/kg in premature neonates given a 20mg/kg intramuscular injection.

Half Life

44 hours in premature neonates given a 20mg/kg intramuscular injection. 12 minutes in intravenous injection of intestinal lymph.

Clearance

6.5mL/hr/kg in premature neonates given a 20mg/kg intramuscular injection.

Pregnancy & Breastfeeding use

Use in pregnancy: Alfa E may be used in pregnancy in the normally recommended dose but the safety of high dose therapy has not been established. 

Use in lactation: There appears to be no contraindication to breast feeding by mothers taking the normally recommended dose.

Contraindication

No known contraindications found.

Special Warning

Use in Children: Alfa E is safe for children

Acute Overdose

Large doses of vitamin E (more than 1 gm/day) have been reported to increase bleeding tendency in vitamin K deficient patients such as those taking oral anticoagulants.

Storage Condition

Store at a cool and dry place, Protect from light and moisture.