Aldonist Tablet

Aldonist selectively binds to the mineralocorticoid receptor and blocks the binding of aldosterone, a key component in the renin-angiotensin-aldosterone-system, which is involved in the regulation of BP and pathophysiology of CV disease. Aldosterone binds to mineralocorticoid receptors in both epithelial (e.g. kidney, GI tract) and nonepithelial (e.g. heart, blood vessels, brain) tissues; causing increases in BP by inducing Na reabsorption, vascular remodelling, water retention, endothelial dysfunction and possibly other mechanisms.


Congestive heart failure after an acute myocardial infarction, Hypertension.

Aldonist is also used to associated treatment for these conditions: High Blood Pressure (Hypertension), LVEF <40% Congestive heart failure, Chronic heart failure with reduced ejection fraction (NYHA Class II)

Trade Name Aldonist
Generic Eplerenone
Other Names Eplerenona, Eplerenone, Epoxymexrenone
Weight 25mg, 50mg
Type Tablet
Formula C24H30O6
Weight Average: 414.4914
Monoisotopic: 414.204238692
Protein binding


Therapeutic Class Potassium-sparing diuretics, Potassium-sparing diuretics & Aldosterone antagonists
Manufacturer Unimed Unihealth MFG, Ltd
Available Country Bangladesh
Last Updated: June 23, 2021 at 11:20 am


Aldonist dosage

Congestive Heart Failure after an acute Myocardial Infarction: The recommended dose of Aldonist is 50 mg once daily. Treatment should be initiated at 25 mg once daily and titrated to the target dose of 50 mg once daily preferably within 4 weeks as tolerated by the patient. Aldonist may be administered with or without food.

Hypertension: Aldonist may be used alone or in combination with other antihypertensive agents. The recommended starting dose of Aldonist is 50 mg administered once daily. For patients with an inadequate blood pressure response to 50 mg once daily the dosage of Aldonist should be increased to 50 mg twice daily. Higher dosages of Aldonist are not recommended either because they have no greater effect on blood pressure than 100 mg or because they are associated with an increased risk of hyperkalemia.

Side Effects

Headache, dizziness, diarrhea, stomach pain, nausea, cough or flu-like symptoms may occur. Symptoms of a serious allergic reaction like: rash, itching, swelling, severe dizziness, trouble breathing can occur.


Aldonist should be used with caution in hyperkalemia, severe kidney disease, diabetic patients with congestive heart failure after an acute myocardial infarction including those with proteinuria.


May increase risk of hyperkalaemia with ACE inhibitors and/or angiotension receptor blocker, ciclosporin, tacrolimus, trimethoprim. May reduce antihypertensive effect with NSAIDs, glucocorticoids, tetracosactide. May enhance hypotensive effect of α1-blockers (e.g. alfuzosin, prazosin), TCAs, amifostine, baclofen, neuroleptics. May increase plasma level with mild to moderate CYP3A4 inhibitors (e.g. fluconazole, erythromycin, saquinavir, amiodarone, diltiazem, verapamil).

Food Interaction

  • Avoid grapefruit products. Grapefruit juice may increase the serum levels of eplerenone by 25% by inhibiting CYP3A4.
  • Take with or without food.

Volume of Distribution

  • 43 to 90 L

Half Life

4-6 hours


  • Apparent plasma cl=10 L/hr

Pregnancy & Breastfeeding use

Pregnancy: There are no adequate and well-controlled studies in pregnant women. Aldonist should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation: The concentration of Aldonist in human breast milk after oral administration is unknown. Because many drugs are excreted in human milk and because of the unknown potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.


Aldonist is contraindicated in-

  • Hyperkalaemia
  • Severe renal impairment (creatinine clearance less than 30 ml/min)
  • Severe hepatic impairment
  • Concomitant use with potent CYP3A4 inhibitors like Ketoconazole, Itraconazole, Nefazodone, Troleandomycin, Clarithromycin, Ritonavir, and Nelfinavir or other
  • Potassium-sparing diuretics are also contraindicated

Special Warning

Pediatric use: The safety and effectiveness of Aldonist has not been established in pediatric patients.

Geriatric use: No differences in overall incidence of effectivity or safety was observed in elderly patients.

Acute Overdose

Symptoms: Hyperkalaemia, hypotension. 

Management: Symptomatic and supportive treatment. Admin activated charcoal. Initiate standard therapy for hyperkalaemia.

Storage Condition

Store below 30°C in a cool and dry place, protected from light and moisture. Keep out of children’s reach.

Aldonist contains Eplerenone see full prescribing information from innovator Monograph