Aldesleukin

Aldesleukin Uses, Dosage, Side Effects, Food Interaction and all others data.

Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from native interleukin-2 in the following ways: a) Aldesleukin is not glycosylated because it is derived from E. coli; b) the molecule has no N-terminal alanine; the codon for this amino acid was deleted during the genetic engineering procedure; c) the molecule has serine substituted for cysteine at amino acid position 125.

Used to treat renal cell carcinoma, Aldesleukin induces the enhancement of lymphocyte mitogenesis and stimulation of long-term growth of human interleukin-2 dependent cell lines, the enhancement of lymphocyte cytotoxicity, the induction of killer cell (lymphokine-activated (LAK) and natural (NK)) activity; and the induction of interferon-gamma production. IL-2 is normally produced by the body, secreted by T cells, and stimulates growth and differentiation of T cell response. It can be used in immunotherapy to treat cancer. It enhances the ability of the immune system to kill tumor cells and may interfere with blood flow to the tumor.

Aldesleukin
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Aldesleukin
Availability	Prescription only
Generic	Aldesleukin
Aldesleukin Other Names	125-L-serine-2-133-interleukin 2 (human reduced), Aldesleukin, Aldesleukina, ILT-101, ILT101, Interleukin-2 aldesleukin, Interleukin-2(2-133),125-ser, Recombinant human interleukin-2, Recombinant interleukin-2 human
Related Drugs	Keytruda, pembrolizumab, Avastin, bevacizumab, Opdivo, nivolumab, atezolizumab, Afinitor, ipilimumab, Yervoy
Weight	22000000intlunits,
Type	Intravenous Powder For Injection, Intravenous
Formula	C₆₉₀H₁₁₁₅N₁₇₇O₂₀₂S₆
Weight	15314.8 Da
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Aldesleukin is a recombinant analog of interleukin-2 used to induce an adaptive immune response in the treatment of renal cell carcinoma.

For treatment of adults with metastatic renal cell carcinoma.

Aldesleukin is also used to associated treatment for these conditions: High Risk Neuroblastoma, Metastatic Melanoma, Metastatic Renal Cell Carcinoma

How Aldesleukin works

Aldesleukin binds to the IL-2 receptor which leads to heterodimerization of the cytoplasmic domains of the IL-2R beta and gamma(c) chains, activation of the tyrosine kinase Jak3, and phosphorylation of tyrosine residues on the IL-2R beta chain. These events led to the creation of an activated receptor complex, to which various cytoplasmic signaling molecules are recruited and become substrates for regulatory enzymes (especially tyrosine kinases) that are associated with the receptor. These events stimulate growth and differentiation of T cells.

Food Interaction

No interactions found.

Aldesleukin Drug Interaction

Moderate: quinapril, quinapril, nifedipine, nifedipine, zolpidem, zolpidemUnknown: paclitaxel protein-bound, paclitaxel protein-bound, acetaminophen, acetaminophen, aspirin, aspirin, rabeprazole, rabeprazole, pioglitazone, pioglitazone, rosuvastatin, rosuvastatin, ketorolac, ketorolac

Aldesleukin Disease Interaction

Major: autoimmune diseases, cardiovascular disease, edema, hepatic dysfunction, hypotension, myelosuppression, neutrophil dysfunction, organ transplant, pulmonary dysfunction, renal dysfunction, seizuresModerate: mental status changes

Volume of Distribution

0.18 l/kg

Half Life

13 min-85 min

Elimination Route

The pharmacokinetic profile of Proleukin is characterized by high plasma concentrations following a short IV infusion, rapid distribution into the extravascular space and elimination from the body by metabolism in the kidneys with little or no bioactive protein excreted in the urine. Following the initial rapid organ distribution, the primary route of clearance of circulating proleukin is the kidney. Greater than 80% of the amount of Proleukin distributed to plasma, cleared from the circulation and presented to the kidney is metabolized to amino acids in the cells lining the proximal convoluted tubules.